Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1N4P

Protein Geranylgeranyltransferase type-I Complexed with Geranylgeranyl Diphosphate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004660	molecular_function	protein farnesyltransferase activity
A	0004661	molecular_function	protein geranylgeranyltransferase activity
A	0004662	molecular_function	CAAX-protein geranylgeranyltransferase activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005953	cellular_component	CAAX-protein geranylgeranyltransferase complex
A	0005965	cellular_component	protein farnesyltransferase complex
A	0007323	biological_process	peptide pheromone maturation
A	0008270	molecular_function	zinc ion binding
A	0008284	biological_process	positive regulation of cell population proliferation
A	0008318	molecular_function	protein prenyltransferase activity
A	0018342	biological_process	protein prenylation
A	0018343	biological_process	protein farnesylation
A	0018344	biological_process	protein geranylgeranylation
A	0036094	molecular_function	small molecule binding
A	0042277	molecular_function	peptide binding
A	0043066	biological_process	negative regulation of apoptotic process
A	0045787	biological_process	positive regulation of cell cycle
A	1901363	molecular_function	heterocyclic compound binding
B	0003824	molecular_function	catalytic activity
B	0004661	molecular_function	protein geranylgeranyltransferase activity
B	0004662	molecular_function	CAAX-protein geranylgeranyltransferase activity
B	0005515	molecular_function	protein binding
B	0005953	cellular_component	CAAX-protein geranylgeranyltransferase complex
B	0008270	molecular_function	zinc ion binding
B	0008284	biological_process	positive regulation of cell population proliferation
B	0008318	molecular_function	protein prenyltransferase activity
B	0018344	biological_process	protein geranylgeranylation
B	0036094	molecular_function	small molecule binding
B	0042277	molecular_function	peptide binding
B	0045787	biological_process	positive regulation of cell cycle
B	1901363	molecular_function	heterocyclic compound binding
C	0004660	molecular_function	protein farnesyltransferase activity
C	0004661	molecular_function	protein geranylgeranyltransferase activity
C	0004662	molecular_function	CAAX-protein geranylgeranyltransferase activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005953	cellular_component	CAAX-protein geranylgeranyltransferase complex
C	0005965	cellular_component	protein farnesyltransferase complex
C	0007323	biological_process	peptide pheromone maturation
C	0008270	molecular_function	zinc ion binding
C	0008284	biological_process	positive regulation of cell population proliferation
C	0008318	molecular_function	protein prenyltransferase activity
C	0018342	biological_process	protein prenylation
C	0018343	biological_process	protein farnesylation
C	0018344	biological_process	protein geranylgeranylation
C	0036094	molecular_function	small molecule binding
C	0042277	molecular_function	peptide binding
C	0043066	biological_process	negative regulation of apoptotic process
C	0045787	biological_process	positive regulation of cell cycle
C	1901363	molecular_function	heterocyclic compound binding
D	0003824	molecular_function	catalytic activity
D	0004661	molecular_function	protein geranylgeranyltransferase activity
D	0004662	molecular_function	CAAX-protein geranylgeranyltransferase activity
D	0005515	molecular_function	protein binding
D	0005953	cellular_component	CAAX-protein geranylgeranyltransferase complex
D	0008270	molecular_function	zinc ion binding
D	0008284	biological_process	positive regulation of cell population proliferation
D	0008318	molecular_function	protein prenyltransferase activity
D	0018344	biological_process	protein geranylgeranylation
D	0036094	molecular_function	small molecule binding
D	0042277	molecular_function	peptide binding
D	0045787	biological_process	positive regulation of cell cycle
D	1901363	molecular_function	heterocyclic compound binding
E	0004660	molecular_function	protein farnesyltransferase activity
E	0004661	molecular_function	protein geranylgeranyltransferase activity
E	0004662	molecular_function	CAAX-protein geranylgeranyltransferase activity
E	0005515	molecular_function	protein binding
E	0005737	cellular_component	cytoplasm
E	0005953	cellular_component	CAAX-protein geranylgeranyltransferase complex
E	0005965	cellular_component	protein farnesyltransferase complex
E	0007323	biological_process	peptide pheromone maturation
E	0008270	molecular_function	zinc ion binding
E	0008284	biological_process	positive regulation of cell population proliferation
E	0008318	molecular_function	protein prenyltransferase activity
E	0018342	biological_process	protein prenylation
E	0018343	biological_process	protein farnesylation
E	0018344	biological_process	protein geranylgeranylation
E	0036094	molecular_function	small molecule binding
E	0042277	molecular_function	peptide binding
E	0043066	biological_process	negative regulation of apoptotic process
E	0045787	biological_process	positive regulation of cell cycle
E	1901363	molecular_function	heterocyclic compound binding
F	0003824	molecular_function	catalytic activity
F	0004661	molecular_function	protein geranylgeranyltransferase activity
F	0004662	molecular_function	CAAX-protein geranylgeranyltransferase activity
F	0005515	molecular_function	protein binding
F	0005953	cellular_component	CAAX-protein geranylgeranyltransferase complex
F	0008270	molecular_function	zinc ion binding
F	0008284	biological_process	positive regulation of cell population proliferation
F	0008318	molecular_function	protein prenyltransferase activity
F	0018344	biological_process	protein geranylgeranylation
F	0036094	molecular_function	small molecule binding
F	0042277	molecular_function	peptide binding
F	0045787	biological_process	positive regulation of cell cycle
F	1901363	molecular_function	heterocyclic compound binding
G	0004660	molecular_function	protein farnesyltransferase activity
G	0004661	molecular_function	protein geranylgeranyltransferase activity
G	0004662	molecular_function	CAAX-protein geranylgeranyltransferase activity
G	0005515	molecular_function	protein binding
G	0005737	cellular_component	cytoplasm
G	0005953	cellular_component	CAAX-protein geranylgeranyltransferase complex
G	0005965	cellular_component	protein farnesyltransferase complex
G	0007323	biological_process	peptide pheromone maturation
G	0008270	molecular_function	zinc ion binding
G	0008284	biological_process	positive regulation of cell population proliferation
G	0008318	molecular_function	protein prenyltransferase activity
G	0018342	biological_process	protein prenylation
G	0018343	biological_process	protein farnesylation
G	0018344	biological_process	protein geranylgeranylation
G	0036094	molecular_function	small molecule binding
G	0042277	molecular_function	peptide binding
G	0043066	biological_process	negative regulation of apoptotic process
G	0045787	biological_process	positive regulation of cell cycle
G	1901363	molecular_function	heterocyclic compound binding
H	0003824	molecular_function	catalytic activity
H	0004661	molecular_function	protein geranylgeranyltransferase activity
H	0004662	molecular_function	CAAX-protein geranylgeranyltransferase activity
H	0005515	molecular_function	protein binding
H	0005953	cellular_component	CAAX-protein geranylgeranyltransferase complex
H	0008270	molecular_function	zinc ion binding
H	0008284	biological_process	positive regulation of cell population proliferation
H	0008318	molecular_function	protein prenyltransferase activity
H	0018344	biological_process	protein geranylgeranylation
H	0036094	molecular_function	small molecule binding
H	0042277	molecular_function	peptide binding
H	0045787	biological_process	positive regulation of cell cycle
H	1901363	molecular_function	heterocyclic compound binding
I	0004660	molecular_function	protein farnesyltransferase activity
I	0004661	molecular_function	protein geranylgeranyltransferase activity
I	0004662	molecular_function	CAAX-protein geranylgeranyltransferase activity
I	0005515	molecular_function	protein binding
I	0005737	cellular_component	cytoplasm
I	0005953	cellular_component	CAAX-protein geranylgeranyltransferase complex
I	0005965	cellular_component	protein farnesyltransferase complex
I	0007323	biological_process	peptide pheromone maturation
I	0008270	molecular_function	zinc ion binding
I	0008284	biological_process	positive regulation of cell population proliferation
I	0008318	molecular_function	protein prenyltransferase activity
I	0018342	biological_process	protein prenylation
I	0018343	biological_process	protein farnesylation
I	0018344	biological_process	protein geranylgeranylation
I	0036094	molecular_function	small molecule binding
I	0042277	molecular_function	peptide binding
I	0043066	biological_process	negative regulation of apoptotic process
I	0045787	biological_process	positive regulation of cell cycle
I	1901363	molecular_function	heterocyclic compound binding
J	0003824	molecular_function	catalytic activity
J	0004661	molecular_function	protein geranylgeranyltransferase activity
J	0004662	molecular_function	CAAX-protein geranylgeranyltransferase activity
J	0005515	molecular_function	protein binding
J	0005953	cellular_component	CAAX-protein geranylgeranyltransferase complex
J	0008270	molecular_function	zinc ion binding
J	0008284	biological_process	positive regulation of cell population proliferation
J	0008318	molecular_function	protein prenyltransferase activity
J	0018344	biological_process	protein geranylgeranylation
J	0036094	molecular_function	small molecule binding
J	0042277	molecular_function	peptide binding
J	0045787	biological_process	positive regulation of cell cycle
J	1901363	molecular_function	heterocyclic compound binding
K	0004660	molecular_function	protein farnesyltransferase activity
K	0004661	molecular_function	protein geranylgeranyltransferase activity
K	0004662	molecular_function	CAAX-protein geranylgeranyltransferase activity
K	0005515	molecular_function	protein binding
K	0005737	cellular_component	cytoplasm
K	0005953	cellular_component	CAAX-protein geranylgeranyltransferase complex
K	0005965	cellular_component	protein farnesyltransferase complex
K	0007323	biological_process	peptide pheromone maturation
K	0008270	molecular_function	zinc ion binding
K	0008284	biological_process	positive regulation of cell population proliferation
K	0008318	molecular_function	protein prenyltransferase activity
K	0018342	biological_process	protein prenylation
K	0018343	biological_process	protein farnesylation
K	0018344	biological_process	protein geranylgeranylation
K	0036094	molecular_function	small molecule binding
K	0042277	molecular_function	peptide binding
K	0043066	biological_process	negative regulation of apoptotic process
K	0045787	biological_process	positive regulation of cell cycle
K	1901363	molecular_function	heterocyclic compound binding
L	0003824	molecular_function	catalytic activity
L	0004661	molecular_function	protein geranylgeranyltransferase activity
L	0004662	molecular_function	CAAX-protein geranylgeranyltransferase activity
L	0005515	molecular_function	protein binding
L	0005953	cellular_component	CAAX-protein geranylgeranyltransferase complex
L	0008270	molecular_function	zinc ion binding
L	0008284	biological_process	positive regulation of cell population proliferation
L	0008318	molecular_function	protein prenyltransferase activity
L	0018344	biological_process	protein geranylgeranylation
L	0036094	molecular_function	small molecule binding
L	0042277	molecular_function	peptide binding
L	0045787	biological_process	positive regulation of cell cycle
L	1901363	molecular_function	heterocyclic compound binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 378

Chain	Residue
B	ASP269
B	CYS271
B	HIS321
B	HOH1027

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL B 1702

Chain	Residue
B	LYS284
B	ILE285
B	PHE286
B	GLN287

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN D 378

Chain	Residue
D	CYS271
D	HIS321
D	HOH1035
D	ASP269

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL C 1705

Chain	Residue
C	ARG287
C	ARG291
C	TYR292

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL D 1706

Chain	Residue
D	LYS284
D	ILE285
D	PHE286
D	GLN287

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN F 378

Chain	Residue
F	ASP269
F	CYS271
F	HIS321
F	HOH1051

site_id	AC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL F 1709

Chain	Residue
F	LYS284
F	PHE286
F	GLN287

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN H 378

Chain	Residue
H	ASP269
H	CYS271
H	HIS321

site_id	AC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL G 1711

Chain	Residue
G	ARG287
G	TYR292
G	HOH383

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL H 1712

Chain	Residue
H	LYS284
H	ILE285
H	PHE286
H	GLN287

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN J 378

Chain	Residue
J	ASP269
J	CYS271
J	HIS321
J	HOH1025

site_id	BC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL J 1715

Chain	Residue
J	LYS281
J	LYS284
J	ILE285
J	PHE286
J	GLN287

site_id	BC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN L 378

Chain	Residue
L	ASP269
L	CYS271
L	HIS321
L	HOH1019

site_id	BC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL K 1717

Chain	Residue
A	HOH409
K	ARG287
K	TYR292
K	HOH391
K	HOH444

site_id	BC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL L 1718

Chain	Residue
L	LYS284
L	ILE285
L	PHE286
L	GLN287

site_id	BC7
Number of Residues	13
Details	BINDING SITE FOR RESIDUE GRG B 1721

Chain	Residue
A	TYR200
B	ARG173
B	HIS219
B	GLY221
B	ARG263
B	LYS266
B	TYR272
B	TRP275
B	ASN345
B	HOH393
B	HOH403
B	HOH743
B	HOH749

site_id	BC8
Number of Residues	15
Details	BINDING SITE FOR RESIDUE GRG D 1722

Chain	Residue
C	TYR200
C	HOH1067
D	PHE53
D	ARG173
D	HIS219
D	GLY221
D	ARG263
D	LYS266
D	TYR272
D	TRP275
D	ASN345
D	HOH384
D	HOH420
D	HOH746
D	HOH1208

site_id	BC9
Number of Residues	14
Details	BINDING SITE FOR RESIDUE GRG F 1723

Chain	Residue
F	HOH1213
E	TYR200
F	THR127
F	ARG173
F	HIS219
F	GLY221
F	ARG263
F	LYS266
F	TYR272
F	TRP275
F	ASN345
F	HOH604
F	HOH747
F	HOH993

site_id	CC1
Number of Residues	15
Details	BINDING SITE FOR RESIDUE GRG H 1724

Chain	Residue
G	LYS164
G	TYR200
H	PHE53
H	ARG173
H	HIS219
H	GLY221
H	ARG263
H	LYS266
H	TYR272
H	TRP275
H	ASN345
H	HOH450
H	HOH508
H	HOH998
H	HOH1609

site_id	CC2
Number of Residues	14
Details	BINDING SITE FOR RESIDUE GRG J 1725

Chain	Residue
I	TYR200
J	ARG173
J	HIS219
J	GLY221
J	ARG263
J	LYS266
J	TYR272
J	TRP275
J	ASN345
J	HOH388
J	HOH527
J	HOH600
J	HOH642
J	HOH1039

site_id	CC3
Number of Residues	15
Details	BINDING SITE FOR RESIDUE GRG L 1726

Chain	Residue
K	TYR200
L	THR127
L	ARG173
L	HIS219
L	GLY221
L	ARG263
L	LYS266
L	TYR272
L	TRP275
L	ASN345
L	HOH386
L	HOH486
L	HOH591
L	HOH745
L	HOH1026

site_id	CC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GER M 1727

Chain	Residue
J	TYR40
J	ILE50
J	PHE53
J	ASP318
J	ALA319
M	CYS508
M	VAL509

site_id	CC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GER N 1727

Chain	Residue
L	TYR40
L	ILE50
L	PHE53
L	ASP318
L	ALA319
N	CYS608
N	VAL609

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	204
Details	Repeat: {"description":"PFTA 1"}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	204
Details	Repeat: {"description":"PFTA 2"}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	192
Details	Repeat: {"description":"PFTA 3"}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	204
Details	Repeat: {"description":"PFTA 4"}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	204
Details	Repeat: {"description":"PFTA 5"}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	252
Details	Repeat: {"description":"PFTB 1","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	246
Details	Repeat: {"description":"PFTB 2","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	234
Details	Repeat: {"description":"PFTB 3","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	252
Details	Repeat: {"description":"PFTB 4","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	66
Details	Binding site: {"evidences":[{"source":"PubMed","id":"14609943","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1N4P","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	4
Details	Propeptide: {"description":"Removed in mature form","featureId":"PRO_0000030216","evidences":[{"source":"PubMed","id":"8424780","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	2
Details	Modified residue: {"description":"Cysteine methyl ester","evidences":[{"source":"PubMed","id":"8424780","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	2
Details	Lipidation: {"description":"S-geranylgeranyl cysteine","evidences":[{"source":"PubMed","id":"8424780","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1d8d

Chain	Residue	Details
A	LYS164
B	TYR272

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1d8d

Chain	Residue	Details
C	LYS164
D	TYR272

site_id	CSA3
Number of Residues	2
Details	Annotated By Reference To The Literature 1d8d

Chain	Residue	Details
F	TYR272
E	LYS164

site_id	CSA4
Number of Residues	2
Details	Annotated By Reference To The Literature 1d8d

Chain	Residue	Details
H	TYR272
G	LYS164

site_id	CSA5
Number of Residues	2
Details	Annotated By Reference To The Literature 1d8d

Chain	Residue	Details
J	TYR272
I	LYS164

site_id	CSA6
Number of Residues	2
Details	Annotated By Reference To The Literature 1d8d

Chain	Residue	Details
K	LYS164
L	TYR272

site_id	MCSA1
Number of Residues	1
Details	M-CSA 484

Chain	Residue	Details
A	LYS164	electrostatic stabiliser

site_id	MCSA2
Number of Residues	1
Details	M-CSA 484

Chain	Residue	Details
C	LYS164	electrostatic stabiliser

site_id	MCSA3
Number of Residues	1
Details	M-CSA 484

Chain	Residue	Details
E	LYS164	electrostatic stabiliser

site_id	MCSA4
Number of Residues	1
Details	M-CSA 484

Chain	Residue	Details
G	LYS164	electrostatic stabiliser

site_id	MCSA5
Number of Residues	1
Details	M-CSA 484

Chain	Residue	Details
I	LYS164	electrostatic stabiliser

site_id	MCSA6
Number of Residues	1
Details	M-CSA 484

Chain	Residue	Details
K	LYS164	electrostatic stabiliser

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)