1N4K
Crystal structure of the inositol 1,4,5-trisphosphate receptor binding core in complex with IP3
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005220 | molecular_function | inositol 1,4,5-trisphosphate-gated calcium channel activity |
| A | 0005262 | molecular_function | calcium channel activity |
| A | 0005783 | cellular_component | endoplasmic reticulum |
| A | 0006816 | biological_process | calcium ion transport |
| A | 0016020 | cellular_component | membrane |
| A | 0070588 | biological_process | calcium ion transmembrane transport |
| A | 0070679 | molecular_function | inositol 1,4,5 trisphosphate binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE I3P A 1000 |
| Chain | Residue |
| A | ARG265 |
| A | HOH1126 |
| A | HOH1128 |
| A | HOH1139 |
| A | HOH1146 |
| A | HOH1148 |
| A | HOH1157 |
| A | HOH1193 |
| A | HOH1198 |
| A | HOH1222 |
| A | THR267 |
| A | GLY268 |
| A | ARG269 |
| A | LYS508 |
| A | ARG511 |
| A | TYR567 |
| A | ARG568 |
| A | LYS569 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 7 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"12442173","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28416699","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1N4K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5GUG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XA1","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"12442173","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1N4K","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
