1N3S
Biosynthesis of pteridins. Reaction mechanism of GTP cyclohydrolase I
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003934 | molecular_function | GTP cyclohydrolase I activity |
| A | 0005525 | molecular_function | GTP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006729 | biological_process | tetrahydrobiopterin biosynthetic process |
| A | 0006730 | biological_process | one-carbon metabolic process |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0008616 | biological_process | queuosine biosynthetic process |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0032991 | cellular_component | protein-containing complex |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0003934 | molecular_function | GTP cyclohydrolase I activity |
| B | 0005525 | molecular_function | GTP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006729 | biological_process | tetrahydrobiopterin biosynthetic process |
| B | 0006730 | biological_process | one-carbon metabolic process |
| B | 0008270 | molecular_function | zinc ion binding |
| B | 0008616 | biological_process | queuosine biosynthetic process |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0032991 | cellular_component | protein-containing complex |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0003934 | molecular_function | GTP cyclohydrolase I activity |
| C | 0005525 | molecular_function | GTP binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0006729 | biological_process | tetrahydrobiopterin biosynthetic process |
| C | 0006730 | biological_process | one-carbon metabolic process |
| C | 0008270 | molecular_function | zinc ion binding |
| C | 0008616 | biological_process | queuosine biosynthetic process |
| C | 0016787 | molecular_function | hydrolase activity |
| C | 0032991 | cellular_component | protein-containing complex |
| C | 0042802 | molecular_function | identical protein binding |
| C | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| C | 0046872 | molecular_function | metal ion binding |
| D | 0003934 | molecular_function | GTP cyclohydrolase I activity |
| D | 0005525 | molecular_function | GTP binding |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0006729 | biological_process | tetrahydrobiopterin biosynthetic process |
| D | 0006730 | biological_process | one-carbon metabolic process |
| D | 0008270 | molecular_function | zinc ion binding |
| D | 0008616 | biological_process | queuosine biosynthetic process |
| D | 0016787 | molecular_function | hydrolase activity |
| D | 0032991 | cellular_component | protein-containing complex |
| D | 0042802 | molecular_function | identical protein binding |
| D | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| D | 0046872 | molecular_function | metal ion binding |
| E | 0003934 | molecular_function | GTP cyclohydrolase I activity |
| E | 0005525 | molecular_function | GTP binding |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0005829 | cellular_component | cytosol |
| E | 0006729 | biological_process | tetrahydrobiopterin biosynthetic process |
| E | 0006730 | biological_process | one-carbon metabolic process |
| E | 0008270 | molecular_function | zinc ion binding |
| E | 0008616 | biological_process | queuosine biosynthetic process |
| E | 0016787 | molecular_function | hydrolase activity |
| E | 0032991 | cellular_component | protein-containing complex |
| E | 0042802 | molecular_function | identical protein binding |
| E | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| E | 0046872 | molecular_function | metal ion binding |
| F | 0003934 | molecular_function | GTP cyclohydrolase I activity |
| F | 0005525 | molecular_function | GTP binding |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0005829 | cellular_component | cytosol |
| F | 0006729 | biological_process | tetrahydrobiopterin biosynthetic process |
| F | 0006730 | biological_process | one-carbon metabolic process |
| F | 0008270 | molecular_function | zinc ion binding |
| F | 0008616 | biological_process | queuosine biosynthetic process |
| F | 0016787 | molecular_function | hydrolase activity |
| F | 0032991 | cellular_component | protein-containing complex |
| F | 0042802 | molecular_function | identical protein binding |
| F | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| F | 0046872 | molecular_function | metal ion binding |
| G | 0003934 | molecular_function | GTP cyclohydrolase I activity |
| G | 0005525 | molecular_function | GTP binding |
| G | 0005737 | cellular_component | cytoplasm |
| G | 0005829 | cellular_component | cytosol |
| G | 0006729 | biological_process | tetrahydrobiopterin biosynthetic process |
| G | 0006730 | biological_process | one-carbon metabolic process |
| G | 0008270 | molecular_function | zinc ion binding |
| G | 0008616 | biological_process | queuosine biosynthetic process |
| G | 0016787 | molecular_function | hydrolase activity |
| G | 0032991 | cellular_component | protein-containing complex |
| G | 0042802 | molecular_function | identical protein binding |
| G | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| G | 0046872 | molecular_function | metal ion binding |
| H | 0003934 | molecular_function | GTP cyclohydrolase I activity |
| H | 0005525 | molecular_function | GTP binding |
| H | 0005737 | cellular_component | cytoplasm |
| H | 0005829 | cellular_component | cytosol |
| H | 0006729 | biological_process | tetrahydrobiopterin biosynthetic process |
| H | 0006730 | biological_process | one-carbon metabolic process |
| H | 0008270 | molecular_function | zinc ion binding |
| H | 0008616 | biological_process | queuosine biosynthetic process |
| H | 0016787 | molecular_function | hydrolase activity |
| H | 0032991 | cellular_component | protein-containing complex |
| H | 0042802 | molecular_function | identical protein binding |
| H | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| H | 0046872 | molecular_function | metal ion binding |
| I | 0003934 | molecular_function | GTP cyclohydrolase I activity |
| I | 0005525 | molecular_function | GTP binding |
| I | 0005737 | cellular_component | cytoplasm |
| I | 0005829 | cellular_component | cytosol |
| I | 0006729 | biological_process | tetrahydrobiopterin biosynthetic process |
| I | 0006730 | biological_process | one-carbon metabolic process |
| I | 0008270 | molecular_function | zinc ion binding |
| I | 0008616 | biological_process | queuosine biosynthetic process |
| I | 0016787 | molecular_function | hydrolase activity |
| I | 0032991 | cellular_component | protein-containing complex |
| I | 0042802 | molecular_function | identical protein binding |
| I | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| I | 0046872 | molecular_function | metal ion binding |
| J | 0003934 | molecular_function | GTP cyclohydrolase I activity |
| J | 0005525 | molecular_function | GTP binding |
| J | 0005737 | cellular_component | cytoplasm |
| J | 0005829 | cellular_component | cytosol |
| J | 0006729 | biological_process | tetrahydrobiopterin biosynthetic process |
| J | 0006730 | biological_process | one-carbon metabolic process |
| J | 0008270 | molecular_function | zinc ion binding |
| J | 0008616 | biological_process | queuosine biosynthetic process |
| J | 0016787 | molecular_function | hydrolase activity |
| J | 0032991 | cellular_component | protein-containing complex |
| J | 0042802 | molecular_function | identical protein binding |
| J | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| J | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE GTP B 411 |
| Chain | Residue |
| A | HIS112 |
| B | ILE132 |
| B | GLY133 |
| B | LEU134 |
| B | SER135 |
| B | LYS136 |
| B | ARG139 |
| B | HOH412 |
| B | HOH414 |
| G | ARG65 |
| A | VAL150 |
| A | GLN151 |
| A | GLU152 |
| A | HIS179 |
| A | ARG185 |
| A | HOH4412 |
| B | THR87 |
| B | VAL131 |
| site_id | AC2 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE GTP C 1411 |
| Chain | Residue |
| B | HIS112 |
| B | VAL150 |
| B | GLN151 |
| B | GLU152 |
| B | ARG185 |
| C | THR87 |
| C | VAL131 |
| C | ILE132 |
| C | GLY133 |
| C | LEU134 |
| C | SER135 |
| C | LYS136 |
| C | ARG139 |
| C | HOH1415 |
| F | ARG65 |
| site_id | AC3 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE GTP D 2411 |
| Chain | Residue |
| C | HIS112 |
| C | VAL150 |
| C | GLN151 |
| C | GLU152 |
| C | HIS179 |
| C | ARG185 |
| C | HOH1419 |
| D | THR87 |
| D | VAL131 |
| D | ILE132 |
| D | GLY133 |
| D | LEU134 |
| D | SER135 |
| D | LYS136 |
| D | ARG139 |
| D | HOH2430 |
| D | HOH2432 |
| J | ARG65 |
| site_id | AC4 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE GTP E 3411 |
| Chain | Residue |
| D | HIS112 |
| D | VAL150 |
| D | GLN151 |
| D | GLU152 |
| D | HIS179 |
| D | ARG185 |
| E | THR87 |
| E | VAL131 |
| E | ILE132 |
| E | GLY133 |
| E | LEU134 |
| E | SER135 |
| E | LYS136 |
| E | ARG139 |
| E | HOH3416 |
| I | ARG65 |
| site_id | AC5 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE GTP A 4411 |
| Chain | Residue |
| A | THR87 |
| A | VAL131 |
| A | ILE132 |
| A | GLY133 |
| A | LEU134 |
| A | SER135 |
| A | LYS136 |
| A | ARG139 |
| E | HIS112 |
| E | VAL150 |
| E | GLN151 |
| E | GLU152 |
| E | HIS179 |
| E | ARG185 |
| E | HOH3417 |
| H | ARG65 |
| site_id | AC6 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE GTP G 5411 |
| Chain | Residue |
| G | HOH5423 |
| B | ARG65 |
| F | HIS112 |
| F | VAL150 |
| F | GLN151 |
| F | GLU152 |
| F | HIS179 |
| F | ARG185 |
| G | THR87 |
| G | VAL131 |
| G | ILE132 |
| G | GLY133 |
| G | LEU134 |
| G | SER135 |
| G | LYS136 |
| G | ARG139 |
| G | HOH5414 |
| site_id | AC7 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE GTP H 6411 |
| Chain | Residue |
| A | ARG65 |
| G | HIS112 |
| G | VAL150 |
| G | GLN151 |
| G | GLU152 |
| G | HIS179 |
| G | ARG185 |
| H | THR87 |
| H | VAL131 |
| H | ILE132 |
| H | GLY133 |
| H | LEU134 |
| H | SER135 |
| H | LYS136 |
| H | ARG139 |
| H | HOH6415 |
| H | HOH6416 |
| site_id | AC8 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE GTP I 7411 |
| Chain | Residue |
| E | ARG65 |
| H | HIS112 |
| H | VAL150 |
| H | GLN151 |
| H | GLU152 |
| H | HIS179 |
| H | ARG185 |
| I | THR87 |
| I | VAL131 |
| I | ILE132 |
| I | GLY133 |
| I | LEU134 |
| I | SER135 |
| I | LYS136 |
| I | ARG139 |
| site_id | AC9 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE GTP J 8411 |
| Chain | Residue |
| D | ARG65 |
| I | HIS112 |
| I | VAL150 |
| I | GLN151 |
| I | GLU152 |
| I | HIS179 |
| I | ARG185 |
| J | THR87 |
| J | VAL131 |
| J | ILE132 |
| J | GLY133 |
| J | LEU134 |
| J | SER135 |
| J | LYS136 |
| J | ARG139 |
| J | HOH8413 |
| J | HOH8418 |
| J | HOH8419 |
| site_id | BC1 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE GTP F 9411 |
| Chain | Residue |
| C | ARG65 |
| F | THR87 |
| F | VAL131 |
| F | ILE132 |
| F | GLY133 |
| F | LEU134 |
| F | SER135 |
| F | LYS136 |
| F | ARG139 |
| F | HOH9421 |
| F | HOH9422 |
| F | HOH9423 |
| J | HIS112 |
| J | VAL150 |
| J | GLN151 |
| J | GLU152 |
| J | HIS179 |
| J | ARG185 |
Functional Information from PROSITE/UniProt
| site_id | PS00860 |
| Number of Residues | 11 |
| Details | GTP_CYCLOHYDROL_1_2 GTP cyclohydrolase I signature 2. AqRpQVQERLT |
| Chain | Residue | Details |
| A | ALA145-THR155 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 30 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | GLU111 | |
| D | GLU111 | |
| D | PHE114 | |
| D | VAL182 | |
| E | GLU111 | |
| E | PHE114 | |
| E | VAL182 | |
| F | GLU111 | |
| F | PHE114 | |
| F | VAL182 | |
| G | GLU111 | |
| A | PHE114 | |
| G | PHE114 | |
| G | VAL182 | |
| H | GLU111 | |
| H | PHE114 | |
| H | VAL182 | |
| I | GLU111 | |
| I | PHE114 | |
| I | VAL182 | |
| J | GLU111 | |
| J | PHE114 | |
| A | VAL182 | |
| J | VAL182 | |
| B | GLU111 | |
| B | PHE114 | |
| B | VAL182 | |
| C | GLU111 | |
| C | PHE114 | |
| C | VAL182 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1gtp |
| Chain | Residue | Details |
| A | HIS179 | |
| A | HIS112 |
| site_id | CSA10 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1gtp |
| Chain | Residue | Details |
| J | HIS179 | |
| J | HIS112 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1gtp |
| Chain | Residue | Details |
| B | HIS179 | |
| B | HIS112 |
| site_id | CSA3 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1gtp |
| Chain | Residue | Details |
| C | HIS179 | |
| C | HIS112 |
| site_id | CSA4 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1gtp |
| Chain | Residue | Details |
| D | HIS179 | |
| D | HIS112 |
| site_id | CSA5 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1gtp |
| Chain | Residue | Details |
| E | HIS179 | |
| E | HIS112 |
| site_id | CSA6 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1gtp |
| Chain | Residue | Details |
| F | HIS179 | |
| F | HIS112 |
| site_id | CSA7 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1gtp |
| Chain | Residue | Details |
| G | HIS179 | |
| G | HIS112 |
| site_id | CSA8 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1gtp |
| Chain | Residue | Details |
| H | HIS179 | |
| H | HIS112 |
| site_id | CSA9 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1gtp |
| Chain | Residue | Details |
| I | HIS179 | |
| I | HIS112 |
| site_id | MCSA1 |
| Number of Residues | 7 |
| Details | M-CSA 38 |
| Chain | Residue | Details |
| A | GLU111 | metal ligand |
| A | HIS112 | electrostatic stabiliser, hydrogen bond acceptor |
| A | SER113 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| A | PHE114 | metal ligand |
| A | GLU152 | electrostatic stabiliser, hydrogen bond acceptor |
| A | TYR180 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| A | VAL182 | metal ligand |
| site_id | MCSA10 |
| Number of Residues | 7 |
| Details | M-CSA 38 |
| Chain | Residue | Details |
| J | GLU111 | metal ligand |
| J | HIS112 | electrostatic stabiliser, hydrogen bond acceptor |
| J | SER113 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| J | PHE114 | metal ligand |
| J | GLU152 | electrostatic stabiliser, hydrogen bond acceptor |
| J | TYR180 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| J | VAL182 | metal ligand |
| site_id | MCSA2 |
| Number of Residues | 7 |
| Details | M-CSA 38 |
| Chain | Residue | Details |
| B | GLU111 | metal ligand |
| B | HIS112 | electrostatic stabiliser, hydrogen bond acceptor |
| B | SER113 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| B | PHE114 | metal ligand |
| B | GLU152 | electrostatic stabiliser, hydrogen bond acceptor |
| B | TYR180 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| B | VAL182 | metal ligand |
| site_id | MCSA3 |
| Number of Residues | 7 |
| Details | M-CSA 38 |
| Chain | Residue | Details |
| C | GLU111 | metal ligand |
| C | HIS112 | electrostatic stabiliser, hydrogen bond acceptor |
| C | SER113 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| C | PHE114 | metal ligand |
| C | GLU152 | electrostatic stabiliser, hydrogen bond acceptor |
| C | TYR180 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| C | VAL182 | metal ligand |
| site_id | MCSA4 |
| Number of Residues | 7 |
| Details | M-CSA 38 |
| Chain | Residue | Details |
| D | GLU111 | metal ligand |
| D | HIS112 | electrostatic stabiliser, hydrogen bond acceptor |
| D | SER113 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| D | PHE114 | metal ligand |
| D | GLU152 | electrostatic stabiliser, hydrogen bond acceptor |
| D | TYR180 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| D | VAL182 | metal ligand |
| site_id | MCSA5 |
| Number of Residues | 7 |
| Details | M-CSA 38 |
| Chain | Residue | Details |
| E | GLU111 | metal ligand |
| E | HIS112 | electrostatic stabiliser, hydrogen bond acceptor |
| E | SER113 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| E | PHE114 | metal ligand |
| E | GLU152 | electrostatic stabiliser, hydrogen bond acceptor |
| E | TYR180 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| E | VAL182 | metal ligand |
| site_id | MCSA6 |
| Number of Residues | 7 |
| Details | M-CSA 38 |
| Chain | Residue | Details |
| F | GLU111 | metal ligand |
| F | HIS112 | electrostatic stabiliser, hydrogen bond acceptor |
| F | SER113 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| F | PHE114 | metal ligand |
| F | GLU152 | electrostatic stabiliser, hydrogen bond acceptor |
| F | TYR180 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| F | VAL182 | metal ligand |
| site_id | MCSA7 |
| Number of Residues | 7 |
| Details | M-CSA 38 |
| Chain | Residue | Details |
| G | GLU111 | metal ligand |
| G | HIS112 | electrostatic stabiliser, hydrogen bond acceptor |
| G | SER113 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| G | PHE114 | metal ligand |
| G | GLU152 | electrostatic stabiliser, hydrogen bond acceptor |
| G | TYR180 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| G | VAL182 | metal ligand |
| site_id | MCSA8 |
| Number of Residues | 7 |
| Details | M-CSA 38 |
| Chain | Residue | Details |
| H | GLU111 | metal ligand |
| H | HIS112 | electrostatic stabiliser, hydrogen bond acceptor |
| H | SER113 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| H | PHE114 | metal ligand |
| H | GLU152 | electrostatic stabiliser, hydrogen bond acceptor |
| H | TYR180 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| H | VAL182 | metal ligand |
| site_id | MCSA9 |
| Number of Residues | 7 |
| Details | M-CSA 38 |
| Chain | Residue | Details |
| I | GLU111 | metal ligand |
| I | HIS112 | electrostatic stabiliser, hydrogen bond acceptor |
| I | SER113 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| I | PHE114 | metal ligand |
| I | GLU152 | electrostatic stabiliser, hydrogen bond acceptor |
| I | TYR180 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| I | VAL182 | metal ligand |
