Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1N3S

Biosynthesis of pteridins. Reaction mechanism of GTP cyclohydrolase I

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003934	molecular_function	GTP cyclohydrolase I activity
A	0005525	molecular_function	GTP binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006729	biological_process	tetrahydrobiopterin biosynthetic process
A	0006730	biological_process	one-carbon metabolic process
A	0008270	molecular_function	zinc ion binding
A	0008616	biological_process	queuosine biosynthetic process
A	0016787	molecular_function	hydrolase activity
A	0018130	biological_process	obsolete heterocycle biosynthetic process
A	0019438	biological_process	obsolete aromatic compound biosynthetic process
A	0032991	cellular_component	protein-containing complex
A	0042802	molecular_function	identical protein binding
A	0044271	biological_process	obsolete cellular nitrogen compound biosynthetic process
A	0046654	biological_process	tetrahydrofolate biosynthetic process
A	0046872	molecular_function	metal ion binding
A	1901362	biological_process	organic cyclic compound biosynthetic process
B	0003934	molecular_function	GTP cyclohydrolase I activity
B	0005525	molecular_function	GTP binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006729	biological_process	tetrahydrobiopterin biosynthetic process
B	0006730	biological_process	one-carbon metabolic process
B	0008270	molecular_function	zinc ion binding
B	0008616	biological_process	queuosine biosynthetic process
B	0016787	molecular_function	hydrolase activity
B	0018130	biological_process	obsolete heterocycle biosynthetic process
B	0019438	biological_process	obsolete aromatic compound biosynthetic process
B	0032991	cellular_component	protein-containing complex
B	0042802	molecular_function	identical protein binding
B	0044271	biological_process	obsolete cellular nitrogen compound biosynthetic process
B	0046654	biological_process	tetrahydrofolate biosynthetic process
B	0046872	molecular_function	metal ion binding
B	1901362	biological_process	organic cyclic compound biosynthetic process
C	0003934	molecular_function	GTP cyclohydrolase I activity
C	0005525	molecular_function	GTP binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006729	biological_process	tetrahydrobiopterin biosynthetic process
C	0006730	biological_process	one-carbon metabolic process
C	0008270	molecular_function	zinc ion binding
C	0008616	biological_process	queuosine biosynthetic process
C	0016787	molecular_function	hydrolase activity
C	0018130	biological_process	obsolete heterocycle biosynthetic process
C	0019438	biological_process	obsolete aromatic compound biosynthetic process
C	0032991	cellular_component	protein-containing complex
C	0042802	molecular_function	identical protein binding
C	0044271	biological_process	obsolete cellular nitrogen compound biosynthetic process
C	0046654	biological_process	tetrahydrofolate biosynthetic process
C	0046872	molecular_function	metal ion binding
C	1901362	biological_process	organic cyclic compound biosynthetic process
D	0003934	molecular_function	GTP cyclohydrolase I activity
D	0005525	molecular_function	GTP binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006729	biological_process	tetrahydrobiopterin biosynthetic process
D	0006730	biological_process	one-carbon metabolic process
D	0008270	molecular_function	zinc ion binding
D	0008616	biological_process	queuosine biosynthetic process
D	0016787	molecular_function	hydrolase activity
D	0018130	biological_process	obsolete heterocycle biosynthetic process
D	0019438	biological_process	obsolete aromatic compound biosynthetic process
D	0032991	cellular_component	protein-containing complex
D	0042802	molecular_function	identical protein binding
D	0044271	biological_process	obsolete cellular nitrogen compound biosynthetic process
D	0046654	biological_process	tetrahydrofolate biosynthetic process
D	0046872	molecular_function	metal ion binding
D	1901362	biological_process	organic cyclic compound biosynthetic process
E	0003934	molecular_function	GTP cyclohydrolase I activity
E	0005525	molecular_function	GTP binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006729	biological_process	tetrahydrobiopterin biosynthetic process
E	0006730	biological_process	one-carbon metabolic process
E	0008270	molecular_function	zinc ion binding
E	0008616	biological_process	queuosine biosynthetic process
E	0016787	molecular_function	hydrolase activity
E	0018130	biological_process	obsolete heterocycle biosynthetic process
E	0019438	biological_process	obsolete aromatic compound biosynthetic process
E	0032991	cellular_component	protein-containing complex
E	0042802	molecular_function	identical protein binding
E	0044271	biological_process	obsolete cellular nitrogen compound biosynthetic process
E	0046654	biological_process	tetrahydrofolate biosynthetic process
E	0046872	molecular_function	metal ion binding
E	1901362	biological_process	organic cyclic compound biosynthetic process
F	0003934	molecular_function	GTP cyclohydrolase I activity
F	0005525	molecular_function	GTP binding
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006729	biological_process	tetrahydrobiopterin biosynthetic process
F	0006730	biological_process	one-carbon metabolic process
F	0008270	molecular_function	zinc ion binding
F	0008616	biological_process	queuosine biosynthetic process
F	0016787	molecular_function	hydrolase activity
F	0018130	biological_process	obsolete heterocycle biosynthetic process
F	0019438	biological_process	obsolete aromatic compound biosynthetic process
F	0032991	cellular_component	protein-containing complex
F	0042802	molecular_function	identical protein binding
F	0044271	biological_process	obsolete cellular nitrogen compound biosynthetic process
F	0046654	biological_process	tetrahydrofolate biosynthetic process
F	0046872	molecular_function	metal ion binding
F	1901362	biological_process	organic cyclic compound biosynthetic process
G	0003934	molecular_function	GTP cyclohydrolase I activity
G	0005525	molecular_function	GTP binding
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0006729	biological_process	tetrahydrobiopterin biosynthetic process
G	0006730	biological_process	one-carbon metabolic process
G	0008270	molecular_function	zinc ion binding
G	0008616	biological_process	queuosine biosynthetic process
G	0016787	molecular_function	hydrolase activity
G	0018130	biological_process	obsolete heterocycle biosynthetic process
G	0019438	biological_process	obsolete aromatic compound biosynthetic process
G	0032991	cellular_component	protein-containing complex
G	0042802	molecular_function	identical protein binding
G	0044271	biological_process	obsolete cellular nitrogen compound biosynthetic process
G	0046654	biological_process	tetrahydrofolate biosynthetic process
G	0046872	molecular_function	metal ion binding
G	1901362	biological_process	organic cyclic compound biosynthetic process
H	0003934	molecular_function	GTP cyclohydrolase I activity
H	0005525	molecular_function	GTP binding
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0006729	biological_process	tetrahydrobiopterin biosynthetic process
H	0006730	biological_process	one-carbon metabolic process
H	0008270	molecular_function	zinc ion binding
H	0008616	biological_process	queuosine biosynthetic process
H	0016787	molecular_function	hydrolase activity
H	0018130	biological_process	obsolete heterocycle biosynthetic process
H	0019438	biological_process	obsolete aromatic compound biosynthetic process
H	0032991	cellular_component	protein-containing complex
H	0042802	molecular_function	identical protein binding
H	0044271	biological_process	obsolete cellular nitrogen compound biosynthetic process
H	0046654	biological_process	tetrahydrofolate biosynthetic process
H	0046872	molecular_function	metal ion binding
H	1901362	biological_process	organic cyclic compound biosynthetic process
I	0003934	molecular_function	GTP cyclohydrolase I activity
I	0005525	molecular_function	GTP binding
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0006729	biological_process	tetrahydrobiopterin biosynthetic process
I	0006730	biological_process	one-carbon metabolic process
I	0008270	molecular_function	zinc ion binding
I	0008616	biological_process	queuosine biosynthetic process
I	0016787	molecular_function	hydrolase activity
I	0018130	biological_process	obsolete heterocycle biosynthetic process
I	0019438	biological_process	obsolete aromatic compound biosynthetic process
I	0032991	cellular_component	protein-containing complex
I	0042802	molecular_function	identical protein binding
I	0044271	biological_process	obsolete cellular nitrogen compound biosynthetic process
I	0046654	biological_process	tetrahydrofolate biosynthetic process
I	0046872	molecular_function	metal ion binding
I	1901362	biological_process	organic cyclic compound biosynthetic process
J	0003934	molecular_function	GTP cyclohydrolase I activity
J	0005525	molecular_function	GTP binding
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0006729	biological_process	tetrahydrobiopterin biosynthetic process
J	0006730	biological_process	one-carbon metabolic process
J	0008270	molecular_function	zinc ion binding
J	0008616	biological_process	queuosine biosynthetic process
J	0016787	molecular_function	hydrolase activity
J	0018130	biological_process	obsolete heterocycle biosynthetic process
J	0019438	biological_process	obsolete aromatic compound biosynthetic process
J	0032991	cellular_component	protein-containing complex
J	0042802	molecular_function	identical protein binding
J	0044271	biological_process	obsolete cellular nitrogen compound biosynthetic process
J	0046654	biological_process	tetrahydrofolate biosynthetic process
J	0046872	molecular_function	metal ion binding
J	1901362	biological_process	organic cyclic compound biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	18
Details	BINDING SITE FOR RESIDUE GTP B 411

Chain	Residue
A	HIS112
B	ILE132
B	GLY133
B	LEU134
B	SER135
B	LYS136
B	ARG139
B	HOH412
B	HOH414
G	ARG65
A	VAL150
A	GLN151
A	GLU152
A	HIS179
A	ARG185
A	HOH4412
B	THR87
B	VAL131

site_id	AC2
Number of Residues	15
Details	BINDING SITE FOR RESIDUE GTP C 1411

Chain	Residue
B	HIS112
B	VAL150
B	GLN151
B	GLU152
B	ARG185
C	THR87
C	VAL131
C	ILE132
C	GLY133
C	LEU134
C	SER135
C	LYS136
C	ARG139
C	HOH1415
F	ARG65

site_id	AC3
Number of Residues	18
Details	BINDING SITE FOR RESIDUE GTP D 2411

Chain	Residue
C	HIS112
C	VAL150
C	GLN151
C	GLU152
C	HIS179
C	ARG185
C	HOH1419
D	THR87
D	VAL131
D	ILE132
D	GLY133
D	LEU134
D	SER135
D	LYS136
D	ARG139
D	HOH2430
D	HOH2432
J	ARG65

site_id	AC4
Number of Residues	16
Details	BINDING SITE FOR RESIDUE GTP E 3411

Chain	Residue
D	HIS112
D	VAL150
D	GLN151
D	GLU152
D	HIS179
D	ARG185
E	THR87
E	VAL131
E	ILE132
E	GLY133
E	LEU134
E	SER135
E	LYS136
E	ARG139
E	HOH3416
I	ARG65

site_id	AC5
Number of Residues	16
Details	BINDING SITE FOR RESIDUE GTP A 4411

Chain	Residue
A	THR87
A	VAL131
A	ILE132
A	GLY133
A	LEU134
A	SER135
A	LYS136
A	ARG139
E	HIS112
E	VAL150
E	GLN151
E	GLU152
E	HIS179
E	ARG185
E	HOH3417
H	ARG65

site_id	AC6
Number of Residues	17
Details	BINDING SITE FOR RESIDUE GTP G 5411

Chain	Residue
G	HOH5423
B	ARG65
F	HIS112
F	VAL150
F	GLN151
F	GLU152
F	HIS179
F	ARG185
G	THR87
G	VAL131
G	ILE132
G	GLY133
G	LEU134
G	SER135
G	LYS136
G	ARG139
G	HOH5414

site_id	AC7
Number of Residues	17
Details	BINDING SITE FOR RESIDUE GTP H 6411

Chain	Residue
A	ARG65
G	HIS112
G	VAL150
G	GLN151
G	GLU152
G	HIS179
G	ARG185
H	THR87
H	VAL131
H	ILE132
H	GLY133
H	LEU134
H	SER135
H	LYS136
H	ARG139
H	HOH6415
H	HOH6416

site_id	AC8
Number of Residues	15
Details	BINDING SITE FOR RESIDUE GTP I 7411

Chain	Residue
E	ARG65
H	HIS112
H	VAL150
H	GLN151
H	GLU152
H	HIS179
H	ARG185
I	THR87
I	VAL131
I	ILE132
I	GLY133
I	LEU134
I	SER135
I	LYS136
I	ARG139

site_id	AC9
Number of Residues	18
Details	BINDING SITE FOR RESIDUE GTP J 8411

Chain	Residue
D	ARG65
I	HIS112
I	VAL150
I	GLN151
I	GLU152
I	HIS179
I	ARG185
J	THR87
J	VAL131
J	ILE132
J	GLY133
J	LEU134
J	SER135
J	LYS136
J	ARG139
J	HOH8413
J	HOH8418
J	HOH8419

site_id	BC1
Number of Residues	18
Details	BINDING SITE FOR RESIDUE GTP F 9411

Chain	Residue
C	ARG65
F	THR87
F	VAL131
F	ILE132
F	GLY133
F	LEU134
F	SER135
F	LYS136
F	ARG139
F	HOH9421
F	HOH9422
F	HOH9423
J	HIS112
J	VAL150
J	GLN151
J	GLU152
J	HIS179
J	ARG185

Functional Information from PROSITE/UniProt

site_id	PS00860
Number of Residues	11
Details	GTP_CYCLOHYDROL_1_2 GTP cyclohydrolase I signature 2. AqRpQVQERLT

Chain	Residue	Details
A	ALA145-THR155

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	30
Details	BINDING:

Chain	Residue	Details
A	GLU111
A	PHE114
A	VAL182
B	GLU111
B	PHE114
B	VAL182
C	GLU111
C	PHE114
C	VAL182
D	GLU111
D	PHE114
D	VAL182
E	GLU111
E	PHE114
E	VAL182
F	GLU111
F	PHE114
F	VAL182
G	GLU111
G	PHE114
G	VAL182
H	GLU111
H	PHE114
H	VAL182
I	GLU111
I	PHE114
I	VAL182
J	GLU111
J	PHE114
J	VAL182

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	7
Details	M-CSA 38

Chain	Residue	Details
A	GLU111	metal ligand
A	HIS112	electrostatic stabiliser, hydrogen bond acceptor
A	SER113	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor
A	PHE114	metal ligand
A	GLU152	electrostatic stabiliser, hydrogen bond acceptor
A	TYR180	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor
A	VAL182	metal ligand

site_id	MCSA2
Number of Residues	7
Details	M-CSA 38

Chain	Residue	Details
B	GLU111	metal ligand
B	HIS112	electrostatic stabiliser, hydrogen bond acceptor
B	SER113	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor
B	PHE114	metal ligand
B	GLU152	electrostatic stabiliser, hydrogen bond acceptor
B	TYR180	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor
B	VAL182	metal ligand

site_id	MCSA3
Number of Residues	7
Details	M-CSA 38

Chain	Residue	Details
C	HIS112	electrostatic stabiliser, hydrogen bond acceptor
C	SER113	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor
C	PHE114	metal ligand
C	GLU152	electrostatic stabiliser, hydrogen bond acceptor
C	TYR180	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor
C	VAL182	metal ligand
C	GLU111	metal ligand

site_id	MCSA4
Number of Residues	7
Details	M-CSA 38

Chain	Residue	Details
D	GLU111	metal ligand
D	HIS112	electrostatic stabiliser, hydrogen bond acceptor
D	SER113	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor
D	PHE114	metal ligand
D	GLU152	electrostatic stabiliser, hydrogen bond acceptor
D	TYR180	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor
D	VAL182	metal ligand

site_id	MCSA5
Number of Residues	7
Details	M-CSA 38

Chain	Residue	Details
E	GLU111	metal ligand
E	HIS112	electrostatic stabiliser, hydrogen bond acceptor
E	SER113	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor
E	PHE114	metal ligand
E	GLU152	electrostatic stabiliser, hydrogen bond acceptor
E	TYR180	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor
E	VAL182	metal ligand

site_id	MCSA6
Number of Residues	7
Details	M-CSA 38

Chain	Residue	Details
F	GLU111	metal ligand
F	HIS112	electrostatic stabiliser, hydrogen bond acceptor
F	SER113	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor
F	PHE114	metal ligand
F	GLU152	electrostatic stabiliser, hydrogen bond acceptor
F	TYR180	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor
F	VAL182	metal ligand

site_id	MCSA7
Number of Residues	7
Details	M-CSA 38

Chain	Residue	Details
G	GLU111	metal ligand
G	HIS112	electrostatic stabiliser, hydrogen bond acceptor
G	SER113	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor
G	PHE114	metal ligand
G	GLU152	electrostatic stabiliser, hydrogen bond acceptor
G	TYR180	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor
G	VAL182	metal ligand

site_id	MCSA8
Number of Residues	7
Details	M-CSA 38

Chain	Residue	Details
H	TYR180	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor
H	VAL182	metal ligand
H	GLU111	metal ligand
H	HIS112	electrostatic stabiliser, hydrogen bond acceptor
H	SER113	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor
H	PHE114	metal ligand
H	GLU152	electrostatic stabiliser, hydrogen bond acceptor

site_id	MCSA9
Number of Residues	7
Details	M-CSA 38

Chain	Residue	Details
I	GLU111	metal ligand
I	HIS112	electrostatic stabiliser, hydrogen bond acceptor
I	SER113	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor
I	PHE114	metal ligand
I	GLU152	electrostatic stabiliser, hydrogen bond acceptor
I	TYR180	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor
I	VAL182	metal ligand

site_id	MCSA10
Number of Residues	7
Details	M-CSA 38

Chain	Residue	Details
J	GLU111	metal ligand
J	HIS112	electrostatic stabiliser, hydrogen bond acceptor
J	SER113	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor
J	PHE114	metal ligand
J	GLU152	electrostatic stabiliser, hydrogen bond acceptor
J	TYR180	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor
J	VAL182	metal ligand

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)