1N28

Crystal structure of the H48Q mutant of human group IIA phospholipase A2

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004623	molecular_function	A2-type glycerophospholipase activity
A	0005509	molecular_function	calcium ion binding
A	0005543	molecular_function	phospholipid binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005741	cellular_component	mitochondrial outer membrane
A	0005783	cellular_component	endoplasmic reticulum
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0005886	cellular_component	plasma membrane
A	0006629	biological_process	lipid metabolic process
A	0006644	biological_process	phospholipid metabolic process
A	0006954	biological_process	inflammatory response
A	0010744	biological_process	positive regulation of macrophage derived foam cell differentiation
A	0016042	biological_process	lipid catabolic process
A	0016787	molecular_function	hydrolase activity
A	0030141	cellular_component	secretory granule
A	0031640	biological_process	killing of cells of another organism
A	0034374	biological_process	low-density lipoprotein particle remodeling
A	0036335	biological_process	intestinal stem cell homeostasis
A	0038166	biological_process	angiotensin-activated signaling pathway
A	0042130	biological_process	negative regulation of T cell proliferation
A	0042742	biological_process	defense response to bacterium
A	0046337	biological_process	phosphatidylethanolamine metabolic process
A	0046470	biological_process	phosphatidylcholine metabolic process
A	0046471	biological_process	phosphatidylglycerol metabolic process
A	0046473	biological_process	phosphatidic acid metabolic process
A	0046872	molecular_function	metal ion binding
A	0048471	cellular_component	perinuclear region of cytoplasm
A	0050482	biological_process	arachidonate secretion
A	0050729	biological_process	positive regulation of inflammatory response
A	0050830	biological_process	defense response to Gram-positive bacterium
A	0070062	cellular_component	extracellular exosome
A	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
A	1902563	biological_process	regulation of neutrophil activation
B	0003824	molecular_function	catalytic activity
B	0004623	molecular_function	A2-type glycerophospholipase activity
B	0005509	molecular_function	calcium ion binding
B	0005543	molecular_function	phospholipid binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005741	cellular_component	mitochondrial outer membrane
B	0005783	cellular_component	endoplasmic reticulum
B	0005789	cellular_component	endoplasmic reticulum membrane
B	0005886	cellular_component	plasma membrane
B	0006629	biological_process	lipid metabolic process
B	0006644	biological_process	phospholipid metabolic process
B	0006954	biological_process	inflammatory response
B	0010744	biological_process	positive regulation of macrophage derived foam cell differentiation
B	0016042	biological_process	lipid catabolic process
B	0016787	molecular_function	hydrolase activity
B	0030141	cellular_component	secretory granule
B	0031640	biological_process	killing of cells of another organism
B	0034374	biological_process	low-density lipoprotein particle remodeling
B	0036335	biological_process	intestinal stem cell homeostasis
B	0038166	biological_process	angiotensin-activated signaling pathway
B	0042130	biological_process	negative regulation of T cell proliferation
B	0042742	biological_process	defense response to bacterium
B	0046337	biological_process	phosphatidylethanolamine metabolic process
B	0046470	biological_process	phosphatidylcholine metabolic process
B	0046471	biological_process	phosphatidylglycerol metabolic process
B	0046473	biological_process	phosphatidic acid metabolic process
B	0046872	molecular_function	metal ion binding
B	0048471	cellular_component	perinuclear region of cytoplasm
B	0050482	biological_process	arachidonate secretion
B	0050729	biological_process	positive regulation of inflammatory response
B	0050830	biological_process	defense response to Gram-positive bacterium
B	0070062	cellular_component	extracellular exosome
B	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
B	1902563	biological_process	regulation of neutrophil activation

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA B 125

Chain	Residue
B	HIS27
B	GLY29
B	GLY31
B	ASP48
B	HOH161

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA A 126

Chain	Residue
A	HOH140
A	HIS27
A	GLY29
A	GLY31
A	ASP48

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA B 127

Chain	Residue
B	PHE23
B	GLY25
B	TYR112
B	ASN114
B	HOH171

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 128

Chain	Residue
A	PHE23
A	GLY25
A	TYR112
A	ASN114
A	HOH165
A	HOH166

---

Functional Information from PROSITE/UniProt

site_id	PS00119
Number of Residues	11
Details	PA2_ASP Phospholipase A2 aspartic acid active site. LCECDKAAaTC

Chain	Residue	Details
B	LEU87-CYS97

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"1948070","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7664108","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1DB4","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"1DB5","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"1DCY","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"1POE","evidenceCode":"ECO:0000312"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Site: {"description":"Important for integrin binding","evidences":[{"source":"PubMed","id":"18635536","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	Annotated By Reference To The Literature 1n29

Chain	Residue	Details
B	GLN47
B	ASP91
B	GLY29

---

site_id	CSA2
Number of Residues	3
Details	Annotated By Reference To The Literature 1n29

Chain	Residue	Details
A	GLN47
A	ASP91
A	GLY29

---