1N0X

Crystal Structure of a Broadly Neutralizing Anti-HIV-1 Antibody in Complex with a Peptide Mimotope

Functional Information from GO Data

Chain	GOid	namespace	contents
L	0002250	biological_process	adaptive immune response
L	0002376	biological_process	immune system process
L	0003823	molecular_function	antigen binding
L	0005576	cellular_component	extracellular region
L	0005615	cellular_component	extracellular space
L	0005886	cellular_component	plasma membrane
L	0006955	biological_process	immune response
L	0016064	biological_process	immunoglobulin mediated immune response
L	0019814	cellular_component	immunoglobulin complex
L	0050853	biological_process	B cell receptor signaling pathway
L	0070062	cellular_component	extracellular exosome
L	0071735	cellular_component	IgG immunoglobulin complex
L	0071738	cellular_component	IgD immunoglobulin complex
L	0071742	cellular_component	IgE immunoglobulin complex
L	0071745	cellular_component	IgA immunoglobulin complex
L	0071753	cellular_component	IgM immunoglobulin complex
L	0072562	cellular_component	blood microparticle
M	0002250	biological_process	adaptive immune response
M	0002376	biological_process	immune system process
M	0003823	molecular_function	antigen binding
M	0005576	cellular_component	extracellular region
M	0005615	cellular_component	extracellular space
M	0005886	cellular_component	plasma membrane
M	0006955	biological_process	immune response
M	0016064	biological_process	immunoglobulin mediated immune response
M	0019814	cellular_component	immunoglobulin complex
M	0050853	biological_process	B cell receptor signaling pathway
M	0070062	cellular_component	extracellular exosome
M	0071735	cellular_component	IgG immunoglobulin complex
M	0071738	cellular_component	IgD immunoglobulin complex
M	0071742	cellular_component	IgE immunoglobulin complex
M	0071745	cellular_component	IgA immunoglobulin complex
M	0071753	cellular_component	IgM immunoglobulin complex
M	0072562	cellular_component	blood microparticle

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 R 901

Chain	Residue
P	HIS1
P	HOH197
R	HIS1
R	GLU2
R	ARG3
R	TYR5
R	HOH916

---

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 R 902

Chain	Residue
R	HOH917
L	SER59
L	ASP60

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 H 903

Chain	Residue
H	ARG83
H	SER84
H	SER195
H	SER196
H	HOH1268

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 K 904

Chain	Residue
K	ARG83
K	ALA85
K	SER196
K	HOH940
K	HOH988

---

site_id	AC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE K P 1001

Chain	Residue
P	HIS1
R	HIS1

---

site_id	AC6
Number of Residues	12
Details	BINDING SITE FOR RESIDUE CXS H 1201

Chain	Residue
H	TYR98
H	TRP100
H	ASP100
H	PRO100
H	HOH1387
M	SER14
M	PRO15
M	GLU17
M	ARG106
M	HOH892
M	HOH966
R	ARG13

---

site_id	AC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL K 801

Chain	Residue
K	ASN31
K	PHE32
K	VAL33
K	VAL95
K	TYR98
K	ASN100
K	TYR100

---

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL L 803

Chain	Residue
H	LYS228
L	SER121
L	ASP122
L	GLU123

---

site_id	AC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL M 804

Chain	Residue
M	PRO8
M	GLY9
M	THR10

---

site_id	BC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE GOL K 805

Chain	Residue
K	SER7
K	GLY8

---

site_id	BC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL K 806

Chain	Residue
K	TYR53
K	ASN54
K	HOH1064
L	ARG18
L	THR76

---

site_id	BC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL H 808

Chain	Residue
H	TYR98
H	SER99
H	TRP100
M	GLU17

---

site_id	BC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL H 809

Chain	Residue
H	ILE51
H	GLY55
H	THR70
H	ALA71

---

site_id	BC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE GOL M 800

Chain	Residue
M	ASP60
M	HOH970

---

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH

Chain	Residue	Details
H	TYR206-HIS212
L	TYR192-HIS198

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI3
Number of Residues	190
Details	Domain: {"description":"Ig-like 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00114","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"Pyrrolidone carboxylic acid","evidences":[{"source":"PubMed","id":"826475","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---