1N0V
Crystal structure of elongation factor 2
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| C | 0003746 | molecular_function | translation elongation factor activity |
| C | 0003924 | molecular_function | GTPase activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005525 | molecular_function | GTP binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0006412 | biological_process | translation |
| C | 0006414 | biological_process | translational elongation |
| C | 0016787 | molecular_function | hydrolase activity |
| C | 0019843 | molecular_function | rRNA binding |
| C | 0042802 | molecular_function | identical protein binding |
| C | 0043022 | molecular_function | ribosome binding |
| C | 0045901 | biological_process | positive regulation of translational elongation |
| C | 0051087 | molecular_function | protein-folding chaperone binding |
| C | 1990145 | biological_process | maintenance of translational fidelity |
| C | 1990904 | cellular_component | ribonucleoprotein complex |
| D | 0003746 | molecular_function | translation elongation factor activity |
| D | 0003924 | molecular_function | GTPase activity |
| D | 0005515 | molecular_function | protein binding |
| D | 0005525 | molecular_function | GTP binding |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0006412 | biological_process | translation |
| D | 0006414 | biological_process | translational elongation |
| D | 0016787 | molecular_function | hydrolase activity |
| D | 0019843 | molecular_function | rRNA binding |
| D | 0042802 | molecular_function | identical protein binding |
| D | 0043022 | molecular_function | ribosome binding |
| D | 0045901 | biological_process | positive regulation of translational elongation |
| D | 0051087 | molecular_function | protein-folding chaperone binding |
| D | 1990145 | biological_process | maintenance of translational fidelity |
| D | 1990904 | cellular_component | ribonucleoprotein complex |
Functional Information from PROSITE/UniProt
| site_id | PS00301 |
| Number of Residues | 16 |
| Details | G_TR_1 Translational (tr)-type guanine nucleotide-binding (G) domain signature. DTrkdEQeRGITIksT |
| Chain | Residue | Details |
| C | ASP58-THR73 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:15316019, ECO:0000305|PubMed:17082187, ECO:0007744|PDB:1U2R, ECO:0007744|PDB:2NPF |
| Chain | Residue | Details |
| C | ALA26 | |
| D | ALA26 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:15316019, ECO:0000305|PubMed:17082187, ECO:0007744|PDB:1U2R, ECO:0007744|PDB:2E1R, ECO:0007744|PDB:2NPF |
| Chain | Residue | Details |
| C | ASN158 | |
| C | SER213 | |
| D | ASN158 | |
| D | SER213 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-methyllysine; by EFM3; alternate => ECO:0000269|PubMed:24517342, ECO:0000269|PubMed:25086354 |
| Chain | Residue | Details |
| C | LYS509 | |
| D | LYS509 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:19779198 |
| Chain | Residue | Details |
| C | SER579 | |
| D | SER579 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-methyllysine; by EFM2; alternate => ECO:0000269|PubMed:24517342, ECO:0000269|PubMed:25086354 |
| Chain | Residue | Details |
| C | LYS613 | |
| D | LYS613 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | MOD_RES: Diphthamide => ECO:0000269|PubMed:15316019, ECO:0000269|PubMed:16950777, ECO:0000269|PubMed:721806 |
| Chain | Residue | Details |
| C | HIS699 | |
| D | HIS699 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:19779198 |
| Chain | Residue | Details |
| C | THR713 | |
| C | THR763 | |
| D | THR713 | |
| D | THR763 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 4 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0007744|PubMed:22106047 |
| Chain | Residue | Details |
| C | LYS841 | |
| D | LYS841 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1ksj |
| Chain | Residue | Details |
| C | ASP29 |
| site_id | CSA2 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1ksj |
| Chain | Residue | Details |
| D | ASP29 |
| site_id | CSA3 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1ksj |
| Chain | Residue | Details |
| C | HIS108 |
| site_id | CSA4 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1ksj |
| Chain | Residue | Details |
| D | HIS108 |
