Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003714 | molecular_function | transcription corepressor activity |
| A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| A | 0051287 | molecular_function | NAD binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 37 |
| Details | BINDING SITE FOR RESIDUE NAD A 1000 |
| Chain | Residue |
| A | SER100 |
| A | ASP204 |
| A | PRO205 |
| A | TYR206 |
| A | HIS236 |
| A | CYS237 |
| A | GLY238 |
| A | ASN240 |
| A | ASN243 |
| A | THR264 |
| A | ALA265 |
| A | GLY101 |
| A | ARG266 |
| A | ASP290 |
| A | VAL291 |
| A | HIS315 |
| A | ALA317 |
| A | TRP318 |
| A | HOH2008 |
| A | HOH2011 |
| A | HOH2012 |
| A | HOH2014 |
| A | THR128 |
| A | HOH2059 |
| A | HOH2086 |
| A | HOH2192 |
| A | HOH2264 |
| A | HOH2347 |
| A | HOH2349 |
| A | HOH2360 |
| A | ACY4000 |
| A | ILE180 |
| A | GLY181 |
| A | GLY183 |
| A | ARG184 |
| A | VAL185 |
| A | TYR203 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE ACY A 4000 |
| Chain | Residue |
| A | ARG97 |
| A | SER100 |
| A | GLY101 |
| A | ARG266 |
| A | HIS315 |
| A | NAD1000 |
| A | HOH2349 |
| A | HOH2354 |
Functional Information from PROSITE/UniProt
| site_id | PS00065 |
| Number of Residues | 28 |
| Details | D_2_HYDROXYACID_DH_1 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature. LGIIGlGRVGqavalrakafgfn.VLfYD |
| Chain | Residue | Details |
| A | LEU177-ASP204 | |
| site_id | PS00671 |
| Number of Residues | 17 |
| Details | D_2_HYDROXYACID_DH_3 D-isomer specific 2-hydroxyacid dehydrogenases signature 3. MRqGaFLVNtARGgLVD |
| Chain | Residue | Details |
| A | MET255-ASP271 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: ACT_SITE => ECO:0000250 |
| Chain | Residue | Details |
| A | ARG266 | |
| A | GLU295 | |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton donor => ECO:0000250 |
| Chain | Residue | Details |
| A | HIS315 | |
| site_id | SWS_FT_FI3 |
| Number of Residues | 7 |
| Details | BINDING: BINDING => ECO:0000250 |
| Chain | Residue | Details |
| A | SER100 | |
| A | ILE180 | |
| A | ASP204 | |
| A | CYS237 | |
| A | THR264 | |
| A | ASP290 | |
| A | HIS315 | |
| Chain | Residue | Details |
| A | SER300 | |
