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1MWH

REOVIRUS POLYMERASE LAMBDA3 BOUND TO MRNA CAP ANALOG

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0001172biological_processRNA-templated transcription
A0003723molecular_functionRNA binding
A0003968molecular_functionRNA-directed RNA polymerase activity
A0016740molecular_functiontransferase activity
A0016779molecular_functionnucleotidyltransferase activity
A0016787molecular_functionhydrolase activity
A0019013cellular_componentviral nucleocapsid
A0019028cellular_componentviral capsid
A0019079biological_processviral genome replication
A0032774biological_processRNA biosynthetic process
A0034062molecular_function5'-3' RNA polymerase activity
A0044423cellular_componentvirion component
Functional Information from PDB Data
site_idAC1
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MN A 1500
ChainResidue
AASP585
AASP735
AGLU780
AHOH2382
AHOH2433

site_idAC2
Number of Residues18
DetailsBINDING SITE FOR RESIDUE GTG A 1425
ChainResidue
APRO813
ATRP814
AARG851
AGLN852
AARG853
ATHR854
AMET855
ATYR862
ALEU1031
AASP1035
AHOH2032
AHOH2450
AHOH2591
AHOH2615
ASER35
AMET36
ASER211
AGLU811

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues237
DetailsDomain: {"description":"RdRp catalytic","evidences":[{"source":"PROSITE-ProRule","id":"PRU00539","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

239149

PDB entries from 2025-07-23

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