1MVL

PPC decarboxylase mutant C175S

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004633	molecular_function	phosphopantothenoylcysteine decarboxylase activity
A	0015937	biological_process	coenzyme A biosynthetic process
A	0016831	molecular_function	carboxy-lyase activity
A	0042538	biological_process	hyperosmotic salinity response

Functional Information from PDB Data

site_id	AC1
Number of Residues	24
Details	BINDING SITE FOR RESIDUE FMN A 1001

Chain	Residue
A	SER27
A	SER106
A	ALA107
A	ASN108
A	THR109
A	CYS118
A	ASP119
A	ALA140
A	MET141
A	HOH1004
A	HOH1007
A	GLY28
A	HOH1015
A	HOH1029
A	HOH1066
A	HOH1097
A	HOH1139
A	SER29
A	VAL30
A	THR53
A	SER55
A	PHE59
A	TRP78
A	TRP81

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton donor => ECO:0000269|PubMed:11279129, ECO:0000269|PubMed:12614618, ECO:0007744|PDB:1MVN

Chain	Residue	Details
A	HIS90

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site_id	SWS_FT_FI2
Number of Residues	1
Details	ACT_SITE: Proton donor => ECO:0000305|PubMed:12614618, ECO:0007744|PDB:1MVN

Chain	Residue	Details
A	SER175

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site_id	SWS_FT_FI3
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:10986463, ECO:0000269|PubMed:12614618, ECO:0007744|PDB:1E20, ECO:0007744|PDB:1MVL

Chain	Residue	Details
A	GLY28
A	THR53
A	SER106
A	ALA140

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site_id	SWS_FT_FI4
Number of Residues	4
Details	BINDING: BINDING => ECO:0000305|PubMed:12614618, ECO:0007744|PDB:1MVN

Chain	Residue	Details
A	ASN142
A	ARG172
A	ALA174
A	MET183

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site_id	SWS_FT_FI5
Number of Residues	1
Details	SITE: Important for catalytic activity => ECO:0000305|PubMed:12614618, ECO:0007744|PDB:1MVN

Chain	Residue	Details
A	SER175

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1mvn

Chain	Residue	Details
A	HIS90

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site_id	MCSA1
Number of Residues	2
Details	M-CSA 639

Chain	Residue	Details
A	HIS90	electrostatic stabiliser, proton acceptor
A	SER175	proton donor

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