1MV8

1.55 A crystal structure of a ternary complex of GDP-mannose dehydrogenase from Psuedomonas aeruginosa

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006970	biological_process	response to osmotic stress
A	0016491	molecular_function	oxidoreductase activity
A	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
A	0036460	biological_process	cellular response to cell envelope stress
A	0042121	biological_process	alginic acid biosynthetic process
A	0044010	biological_process	single-species biofilm formation
A	0047919	molecular_function	GDP-mannose 6-dehydrogenase activity
A	0051287	molecular_function	NAD binding
B	0006970	biological_process	response to osmotic stress
B	0016491	molecular_function	oxidoreductase activity
B	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
B	0036460	biological_process	cellular response to cell envelope stress
B	0042121	biological_process	alginic acid biosynthetic process
B	0044010	biological_process	single-species biofilm formation
B	0047919	molecular_function	GDP-mannose 6-dehydrogenase activity
B	0051287	molecular_function	NAD binding
C	0006970	biological_process	response to osmotic stress
C	0016491	molecular_function	oxidoreductase activity
C	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
C	0036460	biological_process	cellular response to cell envelope stress
C	0042121	biological_process	alginic acid biosynthetic process
C	0044010	biological_process	single-species biofilm formation
C	0047919	molecular_function	GDP-mannose 6-dehydrogenase activity
C	0051287	molecular_function	NAD binding
D	0006970	biological_process	response to osmotic stress
D	0016491	molecular_function	oxidoreductase activity
D	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
D	0036460	biological_process	cellular response to cell envelope stress
D	0042121	biological_process	alginic acid biosynthetic process
D	0044010	biological_process	single-species biofilm formation
D	0047919	molecular_function	GDP-mannose 6-dehydrogenase activity
D	0051287	molecular_function	NAD binding

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCNVWH

Chain	Residue	Details
A	TYR211-HIS217

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Nucleophile => ECO:0000305|PubMed:12705829

Chain	Residue	Details
A	CYS268
B	CYS268
C	CYS268
D	CYS268

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site_id	SWS_FT_FI2
Number of Residues	24
Details	BINDING: in chain A => ECO:0000269|PubMed:12705829, ECO:0007744|PDB:1MUU, ECO:0007744|PDB:1MV8

Chain	Residue	Details
A	TYR10
B	LYS35
B	THR86
B	THR124
C	TYR10
C	VAL11
C	ASP30
C	LYS35
C	THR86
C	THR124
D	TYR10
A	VAL11
D	VAL11
D	ASP30
D	LYS35
D	THR86
D	THR124
A	ASP30
A	LYS35
A	THR86
A	THR124
B	TYR10
B	VAL11
B	ASP30

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site_id	SWS_FT_FI3
Number of Residues	20
Details	BINDING: in chain A => ECO:0000269|PubMed:12705829, ECO:0007744|PDB:1MUU

Chain	Residue	Details
A	GLU161
B	ASN225
C	GLU161
C	LYS210
C	ASN214
C	HIS217
C	ASN225
D	GLU161
D	LYS210
D	ASN214
D	HIS217
A	LYS210
D	ASN225
A	ASN214
A	HIS217
A	ASN225
B	GLU161
B	LYS210
B	ASN214
B	HIS217

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site_id	SWS_FT_FI4
Number of Residues	24
Details	BINDING: in chain B => ECO:0000269|PubMed:12705829, ECO:0007744|PDB:1MUU

Chain	Residue	Details
A	TYR256
B	PHE262
B	GLY265
B	LYS324
C	TYR256
C	TYR257
C	ARG259
C	PHE262
C	GLY265
C	LYS324
D	TYR256
A	TYR257
D	TYR257
D	ARG259
D	PHE262
D	GLY265
D	LYS324
A	ARG259
A	PHE262
A	GLY265
A	LYS324
B	TYR256
B	TYR257
B	ARG259

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site_id	SWS_FT_FI5
Number of Residues	8
Details	BINDING: in chain B => ECO:0000269|PubMed:12705829, ECO:0007744|PDB:1MUU, ECO:0007744|PDB:1MV8

Chain	Residue	Details
A	LYS271
A	ARG331
B	LYS271
B	ARG331
C	LYS271
C	ARG331
D	LYS271
D	ARG331

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