1MV8
1.55 A crystal structure of a ternary complex of GDP-mannose dehydrogenase from Psuedomonas aeruginosa
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0006970 | biological_process | response to osmotic stress |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| A | 0036460 | biological_process | cellular response to cell envelope stress |
| A | 0042121 | biological_process | alginic acid biosynthetic process |
| A | 0044010 | biological_process | single-species biofilm formation |
| A | 0047919 | molecular_function | GDP-mannose 6-dehydrogenase activity |
| A | 0051287 | molecular_function | NAD binding |
| B | 0006970 | biological_process | response to osmotic stress |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| B | 0036460 | biological_process | cellular response to cell envelope stress |
| B | 0042121 | biological_process | alginic acid biosynthetic process |
| B | 0044010 | biological_process | single-species biofilm formation |
| B | 0047919 | molecular_function | GDP-mannose 6-dehydrogenase activity |
| B | 0051287 | molecular_function | NAD binding |
| C | 0006970 | biological_process | response to osmotic stress |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| C | 0036460 | biological_process | cellular response to cell envelope stress |
| C | 0042121 | biological_process | alginic acid biosynthetic process |
| C | 0044010 | biological_process | single-species biofilm formation |
| C | 0047919 | molecular_function | GDP-mannose 6-dehydrogenase activity |
| C | 0051287 | molecular_function | NAD binding |
| D | 0006970 | biological_process | response to osmotic stress |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| D | 0036460 | biological_process | cellular response to cell envelope stress |
| D | 0042121 | biological_process | alginic acid biosynthetic process |
| D | 0044010 | biological_process | single-species biofilm formation |
| D | 0047919 | molecular_function | GDP-mannose 6-dehydrogenase activity |
| D | 0051287 | molecular_function | NAD binding |
Functional Information from PROSITE/UniProt
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCNVWH |
| Chain | Residue | Details |
| A | TYR211-HIS217 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 68 |
| Details | Region: {"description":"Inter-domain linker","evidences":[{"source":"PubMed","id":"1370473","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"12705829","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 24 |
| Details | Binding site: {"description":"in chain A","evidences":[{"source":"PubMed","id":"12705829","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1MUU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1MV8","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 20 |
| Details | Binding site: {"description":"in chain A","evidences":[{"source":"PubMed","id":"12705829","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1MUU","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 24 |
| Details | Binding site: {"description":"in chain B","evidences":[{"source":"PubMed","id":"12705829","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1MUU","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 8 |
| Details | Binding site: {"description":"in chain B","evidences":[{"source":"PubMed","id":"12705829","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1MUU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1MV8","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1dli |
| Chain | Residue | Details |
| A | ASP272 | |
| A | CYS268 | |
| A | GLU161 | |
| A | THR124 | |
| A | ASN214 | |
| A | LYS210 |
| site_id | CSA2 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1dli |
| Chain | Residue | Details |
| B | ASP272 | |
| B | CYS268 | |
| B | GLU161 | |
| B | THR124 | |
| B | ASN214 | |
| B | LYS210 |
| site_id | CSA3 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1dli |
| Chain | Residue | Details |
| C | ASP272 | |
| C | CYS268 | |
| C | GLU161 | |
| C | THR124 | |
| C | ASN214 | |
| C | LYS210 |
| site_id | CSA4 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1dli |
| Chain | Residue | Details |
| D | ASP272 | |
| D | CYS268 | |
| D | GLU161 | |
| D | THR124 | |
| D | ASN214 | |
| D | LYS210 |
