1MT5

CRYSTAL STRUCTURE OF FATTY ACID AMIDE HYDROLASE

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000139	cellular_component	Golgi membrane
A	0004040	molecular_function	amidase activity
A	0005515	molecular_function	protein binding
A	0005543	molecular_function	phospholipid binding
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0006629	biological_process	lipid metabolic process
A	0006631	biological_process	fatty acid metabolic process
A	0008289	molecular_function	lipid binding
A	0009062	biological_process	fatty acid catabolic process
A	0016042	biological_process	lipid catabolic process
A	0016787	molecular_function	hydrolase activity
A	0016788	molecular_function	hydrolase activity, acting on ester bonds
A	0017064	molecular_function	fatty acid amide hydrolase activity
A	0031090	cellular_component	organelle membrane
A	0035902	biological_process	response to immobilization stress
A	0042802	molecular_function	identical protein binding
A	0045471	biological_process	response to ethanol
A	0045907	biological_process	positive regulation of vasoconstriction
A	0047372	molecular_function	monoacylglycerol lipase activity
A	0052651	biological_process	monoacylglycerol catabolic process
A	0098793	cellular_component	presynapse
A	0098794	cellular_component	postsynapse
A	0098978	cellular_component	glutamatergic synapse
A	0150036	biological_process	regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission
B	0000139	cellular_component	Golgi membrane
B	0004040	molecular_function	amidase activity
B	0005515	molecular_function	protein binding
B	0005543	molecular_function	phospholipid binding
B	0005789	cellular_component	endoplasmic reticulum membrane
B	0006629	biological_process	lipid metabolic process
B	0006631	biological_process	fatty acid metabolic process
B	0008289	molecular_function	lipid binding
B	0009062	biological_process	fatty acid catabolic process
B	0016042	biological_process	lipid catabolic process
B	0016787	molecular_function	hydrolase activity
B	0016788	molecular_function	hydrolase activity, acting on ester bonds
B	0017064	molecular_function	fatty acid amide hydrolase activity
B	0031090	cellular_component	organelle membrane
B	0035902	biological_process	response to immobilization stress
B	0042802	molecular_function	identical protein binding
B	0045471	biological_process	response to ethanol
B	0045907	biological_process	positive regulation of vasoconstriction
B	0047372	molecular_function	monoacylglycerol lipase activity
B	0052651	biological_process	monoacylglycerol catabolic process
B	0098793	cellular_component	presynapse
B	0098794	cellular_component	postsynapse
B	0098978	cellular_component	glutamatergic synapse
B	0150036	biological_process	regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission
C	0000139	cellular_component	Golgi membrane
C	0004040	molecular_function	amidase activity
C	0005515	molecular_function	protein binding
C	0005543	molecular_function	phospholipid binding
C	0005789	cellular_component	endoplasmic reticulum membrane
C	0006629	biological_process	lipid metabolic process
C	0006631	biological_process	fatty acid metabolic process
C	0008289	molecular_function	lipid binding
C	0009062	biological_process	fatty acid catabolic process
C	0016042	biological_process	lipid catabolic process
C	0016787	molecular_function	hydrolase activity
C	0016788	molecular_function	hydrolase activity, acting on ester bonds
C	0017064	molecular_function	fatty acid amide hydrolase activity
C	0031090	cellular_component	organelle membrane
C	0035902	biological_process	response to immobilization stress
C	0042802	molecular_function	identical protein binding
C	0045471	biological_process	response to ethanol
C	0045907	biological_process	positive regulation of vasoconstriction
C	0047372	molecular_function	monoacylglycerol lipase activity
C	0052651	biological_process	monoacylglycerol catabolic process
C	0098793	cellular_component	presynapse
C	0098794	cellular_component	postsynapse
C	0098978	cellular_component	glutamatergic synapse
C	0150036	biological_process	regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission
D	0000139	cellular_component	Golgi membrane
D	0004040	molecular_function	amidase activity
D	0005515	molecular_function	protein binding
D	0005543	molecular_function	phospholipid binding
D	0005789	cellular_component	endoplasmic reticulum membrane
D	0006629	biological_process	lipid metabolic process
D	0006631	biological_process	fatty acid metabolic process
D	0008289	molecular_function	lipid binding
D	0009062	biological_process	fatty acid catabolic process
D	0016042	biological_process	lipid catabolic process
D	0016787	molecular_function	hydrolase activity
D	0016788	molecular_function	hydrolase activity, acting on ester bonds
D	0017064	molecular_function	fatty acid amide hydrolase activity
D	0031090	cellular_component	organelle membrane
D	0035902	biological_process	response to immobilization stress
D	0042802	molecular_function	identical protein binding
D	0045471	biological_process	response to ethanol
D	0045907	biological_process	positive regulation of vasoconstriction
D	0047372	molecular_function	monoacylglycerol lipase activity
D	0052651	biological_process	monoacylglycerol catabolic process
D	0098793	cellular_component	presynapse
D	0098794	cellular_component	postsynapse
D	0098978	cellular_component	glutamatergic synapse
D	0150036	biological_process	regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission
E	0000139	cellular_component	Golgi membrane
E	0004040	molecular_function	amidase activity
E	0005515	molecular_function	protein binding
E	0005543	molecular_function	phospholipid binding
E	0005789	cellular_component	endoplasmic reticulum membrane
E	0006629	biological_process	lipid metabolic process
E	0006631	biological_process	fatty acid metabolic process
E	0008289	molecular_function	lipid binding
E	0009062	biological_process	fatty acid catabolic process
E	0016042	biological_process	lipid catabolic process
E	0016787	molecular_function	hydrolase activity
E	0016788	molecular_function	hydrolase activity, acting on ester bonds
E	0017064	molecular_function	fatty acid amide hydrolase activity
E	0031090	cellular_component	organelle membrane
E	0035902	biological_process	response to immobilization stress
E	0042802	molecular_function	identical protein binding
E	0045471	biological_process	response to ethanol
E	0045907	biological_process	positive regulation of vasoconstriction
E	0047372	molecular_function	monoacylglycerol lipase activity
E	0052651	biological_process	monoacylglycerol catabolic process
E	0098793	cellular_component	presynapse
E	0098794	cellular_component	postsynapse
E	0098978	cellular_component	glutamatergic synapse
E	0150036	biological_process	regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission
F	0000139	cellular_component	Golgi membrane
F	0004040	molecular_function	amidase activity
F	0005515	molecular_function	protein binding
F	0005543	molecular_function	phospholipid binding
F	0005789	cellular_component	endoplasmic reticulum membrane
F	0006629	biological_process	lipid metabolic process
F	0006631	biological_process	fatty acid metabolic process
F	0008289	molecular_function	lipid binding
F	0009062	biological_process	fatty acid catabolic process
F	0016042	biological_process	lipid catabolic process
F	0016787	molecular_function	hydrolase activity
F	0016788	molecular_function	hydrolase activity, acting on ester bonds
F	0017064	molecular_function	fatty acid amide hydrolase activity
F	0031090	cellular_component	organelle membrane
F	0035902	biological_process	response to immobilization stress
F	0042802	molecular_function	identical protein binding
F	0045471	biological_process	response to ethanol
F	0045907	biological_process	positive regulation of vasoconstriction
F	0047372	molecular_function	monoacylglycerol lipase activity
F	0052651	biological_process	monoacylglycerol catabolic process
F	0098793	cellular_component	presynapse
F	0098794	cellular_component	postsynapse
F	0098978	cellular_component	glutamatergic synapse
F	0150036	biological_process	regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission
G	0000139	cellular_component	Golgi membrane
G	0004040	molecular_function	amidase activity
G	0005515	molecular_function	protein binding
G	0005543	molecular_function	phospholipid binding
G	0005789	cellular_component	endoplasmic reticulum membrane
G	0006629	biological_process	lipid metabolic process
G	0006631	biological_process	fatty acid metabolic process
G	0008289	molecular_function	lipid binding
G	0009062	biological_process	fatty acid catabolic process
G	0016042	biological_process	lipid catabolic process
G	0016787	molecular_function	hydrolase activity
G	0016788	molecular_function	hydrolase activity, acting on ester bonds
G	0017064	molecular_function	fatty acid amide hydrolase activity
G	0031090	cellular_component	organelle membrane
G	0035902	biological_process	response to immobilization stress
G	0042802	molecular_function	identical protein binding
G	0045471	biological_process	response to ethanol
G	0045907	biological_process	positive regulation of vasoconstriction
G	0047372	molecular_function	monoacylglycerol lipase activity
G	0052651	biological_process	monoacylglycerol catabolic process
G	0098793	cellular_component	presynapse
G	0098794	cellular_component	postsynapse
G	0098978	cellular_component	glutamatergic synapse
G	0150036	biological_process	regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission
H	0000139	cellular_component	Golgi membrane
H	0004040	molecular_function	amidase activity
H	0005515	molecular_function	protein binding
H	0005543	molecular_function	phospholipid binding
H	0005789	cellular_component	endoplasmic reticulum membrane
H	0006629	biological_process	lipid metabolic process
H	0006631	biological_process	fatty acid metabolic process
H	0008289	molecular_function	lipid binding
H	0009062	biological_process	fatty acid catabolic process
H	0016042	biological_process	lipid catabolic process
H	0016787	molecular_function	hydrolase activity
H	0016788	molecular_function	hydrolase activity, acting on ester bonds
H	0017064	molecular_function	fatty acid amide hydrolase activity
H	0031090	cellular_component	organelle membrane
H	0035902	biological_process	response to immobilization stress
H	0042802	molecular_function	identical protein binding
H	0045471	biological_process	response to ethanol
H	0045907	biological_process	positive regulation of vasoconstriction
H	0047372	molecular_function	monoacylglycerol lipase activity
H	0052651	biological_process	monoacylglycerol catabolic process
H	0098793	cellular_component	presynapse
H	0098794	cellular_component	postsynapse
H	0098978	cellular_component	glutamatergic synapse
H	0150036	biological_process	regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission
I	0000139	cellular_component	Golgi membrane
I	0004040	molecular_function	amidase activity
I	0005515	molecular_function	protein binding
I	0005543	molecular_function	phospholipid binding
I	0005789	cellular_component	endoplasmic reticulum membrane
I	0006629	biological_process	lipid metabolic process
I	0006631	biological_process	fatty acid metabolic process
I	0008289	molecular_function	lipid binding
I	0009062	biological_process	fatty acid catabolic process
I	0016042	biological_process	lipid catabolic process
I	0016787	molecular_function	hydrolase activity
I	0016788	molecular_function	hydrolase activity, acting on ester bonds
I	0017064	molecular_function	fatty acid amide hydrolase activity
I	0031090	cellular_component	organelle membrane
I	0035902	biological_process	response to immobilization stress
I	0042802	molecular_function	identical protein binding
I	0045471	biological_process	response to ethanol
I	0045907	biological_process	positive regulation of vasoconstriction
I	0047372	molecular_function	monoacylglycerol lipase activity
I	0052651	biological_process	monoacylglycerol catabolic process
I	0098793	cellular_component	presynapse
I	0098794	cellular_component	postsynapse
I	0098978	cellular_component	glutamatergic synapse
I	0150036	biological_process	regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission
J	0000139	cellular_component	Golgi membrane
J	0004040	molecular_function	amidase activity
J	0005515	molecular_function	protein binding
J	0005543	molecular_function	phospholipid binding
J	0005789	cellular_component	endoplasmic reticulum membrane
J	0006629	biological_process	lipid metabolic process
J	0006631	biological_process	fatty acid metabolic process
J	0008289	molecular_function	lipid binding
J	0009062	biological_process	fatty acid catabolic process
J	0016042	biological_process	lipid catabolic process
J	0016787	molecular_function	hydrolase activity
J	0016788	molecular_function	hydrolase activity, acting on ester bonds
J	0017064	molecular_function	fatty acid amide hydrolase activity
J	0031090	cellular_component	organelle membrane
J	0035902	biological_process	response to immobilization stress
J	0042802	molecular_function	identical protein binding
J	0045471	biological_process	response to ethanol
J	0045907	biological_process	positive regulation of vasoconstriction
J	0047372	molecular_function	monoacylglycerol lipase activity
J	0052651	biological_process	monoacylglycerol catabolic process
J	0098793	cellular_component	presynapse
J	0098794	cellular_component	postsynapse
J	0098978	cellular_component	glutamatergic synapse
J	0150036	biological_process	regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission
K	0000139	cellular_component	Golgi membrane
K	0004040	molecular_function	amidase activity
K	0005515	molecular_function	protein binding
K	0005543	molecular_function	phospholipid binding
K	0005789	cellular_component	endoplasmic reticulum membrane
K	0006629	biological_process	lipid metabolic process
K	0006631	biological_process	fatty acid metabolic process
K	0008289	molecular_function	lipid binding
K	0009062	biological_process	fatty acid catabolic process
K	0016042	biological_process	lipid catabolic process
K	0016787	molecular_function	hydrolase activity
K	0016788	molecular_function	hydrolase activity, acting on ester bonds
K	0017064	molecular_function	fatty acid amide hydrolase activity
K	0031090	cellular_component	organelle membrane
K	0035902	biological_process	response to immobilization stress
K	0042802	molecular_function	identical protein binding
K	0045471	biological_process	response to ethanol
K	0045907	biological_process	positive regulation of vasoconstriction
K	0047372	molecular_function	monoacylglycerol lipase activity
K	0052651	biological_process	monoacylglycerol catabolic process
K	0098793	cellular_component	presynapse
K	0098794	cellular_component	postsynapse
K	0098978	cellular_component	glutamatergic synapse
K	0150036	biological_process	regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission
L	0000139	cellular_component	Golgi membrane
L	0004040	molecular_function	amidase activity
L	0005515	molecular_function	protein binding
L	0005543	molecular_function	phospholipid binding
L	0005789	cellular_component	endoplasmic reticulum membrane
L	0006629	biological_process	lipid metabolic process
L	0006631	biological_process	fatty acid metabolic process
L	0008289	molecular_function	lipid binding
L	0009062	biological_process	fatty acid catabolic process
L	0016042	biological_process	lipid catabolic process
L	0016787	molecular_function	hydrolase activity
L	0016788	molecular_function	hydrolase activity, acting on ester bonds
L	0017064	molecular_function	fatty acid amide hydrolase activity
L	0031090	cellular_component	organelle membrane
L	0035902	biological_process	response to immobilization stress
L	0042802	molecular_function	identical protein binding
L	0045471	biological_process	response to ethanol
L	0045907	biological_process	positive regulation of vasoconstriction
L	0047372	molecular_function	monoacylglycerol lipase activity
L	0052651	biological_process	monoacylglycerol catabolic process
L	0098793	cellular_component	presynapse
L	0098794	cellular_component	postsynapse
L	0098978	cellular_component	glutamatergic synapse
L	0150036	biological_process	regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission
M	0000139	cellular_component	Golgi membrane
M	0004040	molecular_function	amidase activity
M	0005515	molecular_function	protein binding
M	0005543	molecular_function	phospholipid binding
M	0005789	cellular_component	endoplasmic reticulum membrane
M	0006629	biological_process	lipid metabolic process
M	0006631	biological_process	fatty acid metabolic process
M	0008289	molecular_function	lipid binding
M	0009062	biological_process	fatty acid catabolic process
M	0016042	biological_process	lipid catabolic process
M	0016787	molecular_function	hydrolase activity
M	0016788	molecular_function	hydrolase activity, acting on ester bonds
M	0017064	molecular_function	fatty acid amide hydrolase activity
M	0031090	cellular_component	organelle membrane
M	0035902	biological_process	response to immobilization stress
M	0042802	molecular_function	identical protein binding
M	0045471	biological_process	response to ethanol
M	0045907	biological_process	positive regulation of vasoconstriction
M	0047372	molecular_function	monoacylglycerol lipase activity
M	0052651	biological_process	monoacylglycerol catabolic process
M	0098793	cellular_component	presynapse
M	0098794	cellular_component	postsynapse
M	0098978	cellular_component	glutamatergic synapse
M	0150036	biological_process	regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission
N	0000139	cellular_component	Golgi membrane
N	0004040	molecular_function	amidase activity
N	0005515	molecular_function	protein binding
N	0005543	molecular_function	phospholipid binding
N	0005789	cellular_component	endoplasmic reticulum membrane
N	0006629	biological_process	lipid metabolic process
N	0006631	biological_process	fatty acid metabolic process
N	0008289	molecular_function	lipid binding
N	0009062	biological_process	fatty acid catabolic process
N	0016042	biological_process	lipid catabolic process
N	0016787	molecular_function	hydrolase activity
N	0016788	molecular_function	hydrolase activity, acting on ester bonds
N	0017064	molecular_function	fatty acid amide hydrolase activity
N	0031090	cellular_component	organelle membrane
N	0035902	biological_process	response to immobilization stress
N	0042802	molecular_function	identical protein binding
N	0045471	biological_process	response to ethanol
N	0045907	biological_process	positive regulation of vasoconstriction
N	0047372	molecular_function	monoacylglycerol lipase activity
N	0052651	biological_process	monoacylglycerol catabolic process
N	0098793	cellular_component	presynapse
N	0098794	cellular_component	postsynapse
N	0098978	cellular_component	glutamatergic synapse
N	0150036	biological_process	regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission
O	0000139	cellular_component	Golgi membrane
O	0004040	molecular_function	amidase activity
O	0005515	molecular_function	protein binding
O	0005543	molecular_function	phospholipid binding
O	0005789	cellular_component	endoplasmic reticulum membrane
O	0006629	biological_process	lipid metabolic process
O	0006631	biological_process	fatty acid metabolic process
O	0008289	molecular_function	lipid binding
O	0009062	biological_process	fatty acid catabolic process
O	0016042	biological_process	lipid catabolic process
O	0016787	molecular_function	hydrolase activity
O	0016788	molecular_function	hydrolase activity, acting on ester bonds
O	0017064	molecular_function	fatty acid amide hydrolase activity
O	0031090	cellular_component	organelle membrane
O	0035902	biological_process	response to immobilization stress
O	0042802	molecular_function	identical protein binding
O	0045471	biological_process	response to ethanol
O	0045907	biological_process	positive regulation of vasoconstriction
O	0047372	molecular_function	monoacylglycerol lipase activity
O	0052651	biological_process	monoacylglycerol catabolic process
O	0098793	cellular_component	presynapse
O	0098794	cellular_component	postsynapse
O	0098978	cellular_component	glutamatergic synapse
O	0150036	biological_process	regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission
P	0000139	cellular_component	Golgi membrane
P	0004040	molecular_function	amidase activity
P	0005515	molecular_function	protein binding
P	0005543	molecular_function	phospholipid binding
P	0005789	cellular_component	endoplasmic reticulum membrane
P	0006629	biological_process	lipid metabolic process
P	0006631	biological_process	fatty acid metabolic process
P	0008289	molecular_function	lipid binding
P	0009062	biological_process	fatty acid catabolic process
P	0016042	biological_process	lipid catabolic process
P	0016787	molecular_function	hydrolase activity
P	0016788	molecular_function	hydrolase activity, acting on ester bonds
P	0017064	molecular_function	fatty acid amide hydrolase activity
P	0031090	cellular_component	organelle membrane
P	0035902	biological_process	response to immobilization stress
P	0042802	molecular_function	identical protein binding
P	0045471	biological_process	response to ethanol
P	0045907	biological_process	positive regulation of vasoconstriction
P	0047372	molecular_function	monoacylglycerol lipase activity
P	0052651	biological_process	monoacylglycerol catabolic process
P	0098793	cellular_component	presynapse
P	0098794	cellular_component	postsynapse
P	0098978	cellular_component	glutamatergic synapse
P	0150036	biological_process	regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	BINDING SITE FOR RESIDUE MAY A 600

Chain	Residue
A	MET191
A	LEU372
A	ALA377
A	PHE381
A	ARG428
A	ILE491
A	VAL495
A	SER193
A	SER217
A	ASP237
A	ILE238
A	GLY239
A	GLY240
A	SER241
A	TYR335

---

site_id	AC2
Number of Residues	14
Details	BINDING SITE FOR RESIDUE MAY B 600

Chain	Residue
B	MET191
B	LEU192
B	SER193
B	SER217
B	ASP237
B	ILE238
B	GLY239
B	GLY240
B	SER241
B	TYR335
B	LEU372
B	ALA377
B	PHE381
B	ILE491

---

site_id	AC3
Number of Residues	17
Details	BINDING SITE FOR RESIDUE MAY C 600

Chain	Residue
C	MET191
C	LEU192
C	SER193
C	PHE194
C	SER217
C	ASP237
C	ILE238
C	GLY239
C	GLY240
C	SER241
C	TYR335
C	LEU372
C	ALA377
C	LEU380
C	PHE381
C	ILE491
C	VAL495

---

site_id	AC4
Number of Residues	16
Details	BINDING SITE FOR RESIDUE MAY D 600

Chain	Residue
D	MET191
D	SER193
D	SER217
D	ASP237
D	ILE238
D	GLY239
D	GLY240
D	SER241
D	TYR335
D	LEU372
D	ALA377
D	LEU380
D	PHE381
D	PHE432
D	ILE491
D	VAL495

---

site_id	AC5
Number of Residues	16
Details	BINDING SITE FOR RESIDUE MAY E 600

Chain	Residue
E	MET191
E	LEU192
E	SER193
E	SER217
E	ASP237
E	ILE238
E	GLY239
E	GLY240
E	SER241
E	TYR335
E	LEU372
E	ALA377
E	LEU380
E	PHE381
E	ILE491
E	VAL495

---

site_id	AC6
Number of Residues	15
Details	BINDING SITE FOR RESIDUE MAY F 600

Chain	Residue
F	MET191
F	SER193
F	SER217
F	ASP237
F	ILE238
F	GLY239
F	GLY240
F	SER241
F	TYR335
F	LEU372
F	ALA377
F	LEU380
F	PHE381
F	ILE491
F	VAL495

---

site_id	AC7
Number of Residues	14
Details	BINDING SITE FOR RESIDUE MAY G 600

Chain	Residue
G	GLY239
G	GLY240
G	SER241
G	TYR335
G	LEU372
G	PHE381
G	ILE491
G	VAL495
G	MET191
G	SER193
G	PHE194
G	SER217
G	ASP237
G	ILE238

---

site_id	AC8
Number of Residues	15
Details	BINDING SITE FOR RESIDUE MAY H 600

Chain	Residue
H	MET191
H	SER193
H	SER217
H	ASP237
H	ILE238
H	GLY239
H	GLY240
H	SER241
H	TYR335
H	LEU372
H	ALA377
H	LEU380
H	PHE381
H	ILE491
H	VAL495

---

site_id	AC9
Number of Residues	15
Details	BINDING SITE FOR RESIDUE MAY I 600

Chain	Residue
I	MET191
I	SER193
I	PHE194
I	SER217
I	ASP237
I	ILE238
I	GLY239
I	SER241
I	TYR335
I	LEU372
I	ALA377
I	LEU380
I	PHE381
I	ILE491
I	VAL495

---

site_id	BC1
Number of Residues	16
Details	BINDING SITE FOR RESIDUE MAY J 600

Chain	Residue
J	MET191
J	SER193
J	PHE194
J	SER217
J	ASP237
J	ILE238
J	GLY239
J	GLY240
J	SER241
J	TYR335
J	LEU372
J	ALA377
J	LEU380
J	PHE381
J	ILE491
J	TRP531

---

site_id	BC2
Number of Residues	16
Details	BINDING SITE FOR RESIDUE MAY K 600

Chain	Residue
K	MET191
K	LEU192
K	SER193
K	SER217
K	ASP237
K	ILE238
K	GLY239
K	GLY240
K	SER241
K	TYR335
K	LEU372
K	ALA377
K	LEU380
K	PHE381
K	ILE491
K	VAL495

---

site_id	BC3
Number of Residues	16
Details	BINDING SITE FOR RESIDUE MAY L 600

Chain	Residue
L	MET191
L	LEU192
L	SER193
L	PHE194
L	SER217
L	ASP237
L	ILE238
L	GLY239
L	SER241
L	TYR335
L	LEU372
L	PHE381
L	ARG428
L	ILE491
L	VAL495
L	TRP531

---

site_id	BC4
Number of Residues	18
Details	BINDING SITE FOR RESIDUE MAY M 600

Chain	Residue
M	MET191
M	LEU192
M	SER193
M	SER217
M	THR236
M	ASP237
M	ILE238
M	GLY239
M	GLY240
M	SER241
M	TYR335
M	LEU372
M	PHE381
M	LEU404
M	PHE432
M	THR488
M	ILE491
M	VAL495

---

site_id	BC5
Number of Residues	16
Details	BINDING SITE FOR RESIDUE MAY N 600

Chain	Residue
N	MET191
N	LEU192
N	SER193
N	PHE194
N	SER217
N	ASP237
N	ILE238
N	GLY239
N	GLY240
N	SER241
N	TYR335
N	LEU372
N	ALA377
N	PHE381
N	PHE432
N	ILE491

---

site_id	BC6
Number of Residues	16
Details	BINDING SITE FOR RESIDUE MAY O 600

Chain	Residue
O	MET191
O	LEU192
O	SER193
O	SER217
O	ASP237
O	ILE238
O	GLY239
O	GLY240
O	SER241
O	TYR335
O	LEU372
O	ALA377
O	PHE381
O	ILE491
O	VAL495
O	TRP531

---

site_id	BC7
Number of Residues	16
Details	BINDING SITE FOR RESIDUE MAY P 600

Chain	Residue
P	MET191
P	LEU192
P	SER193
P	SER217
P	ASP237
P	ILE238
P	GLY239
P	GLY240
P	SER241
P	TYR335
P	LEU372
P	LEU380
P	PHE381
P	ARG428
P	ILE491
P	TRP531

---

Functional Information from PROSITE/UniProt

site_id	PS00571
Number of Residues	32
Details	AMIDASES Amidases signature. GGSSGGeGAlIGsggsplGlGtDiGgSIRfPS

Chain	Residue	Details
A	GLY215-SER246

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	464
Details	Intramembrane: {"evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	32
Details	Active site: {"description":"Charge relay system"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	16
Details	Active site: {"description":"Acyl-ester intermediate"}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	80
Details	Binding site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	16
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"O00519","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	4
Details

Chain	Residue	Details
A	LYS142
A	SER218
A	ILE238
A	SER241

---

site_id	MCSA1
Number of Residues	7
Details	M-CSA 731

Chain	Residue	Details
A	LYS142	proton acceptor, proton donor
A	SER217	proton acceptor, proton donor, proton relay
A	SER218	electrostatic stabiliser
A	ILE238	electrostatic stabiliser
A	GLY239	electrostatic stabiliser
A	GLY240	electrostatic stabiliser
A	SER241	nucleofuge, nucleophile, proton acceptor, proton donor

---

site_id	MCSA10
Number of Residues	7
Details	M-CSA 731

Chain	Residue	Details
J	LYS142	proton acceptor, proton donor
J	SER217	proton acceptor, proton donor, proton relay
J	SER218	electrostatic stabiliser
J	ILE238	electrostatic stabiliser
J	GLY239	electrostatic stabiliser
J	GLY240	electrostatic stabiliser
J	SER241	nucleofuge, nucleophile, proton acceptor, proton donor

---

site_id	MCSA11
Number of Residues	7
Details	M-CSA 731

Chain	Residue	Details
K	LYS142	proton acceptor, proton donor
K	SER217	proton acceptor, proton donor, proton relay
K	SER218	electrostatic stabiliser
K	ILE238	electrostatic stabiliser
K	GLY239	electrostatic stabiliser
K	GLY240	electrostatic stabiliser
K	SER241	nucleofuge, nucleophile, proton acceptor, proton donor

---

site_id	MCSA12
Number of Residues	7
Details	M-CSA 731

Chain	Residue	Details
L	LYS142	proton acceptor, proton donor
L	SER217	proton acceptor, proton donor, proton relay
L	SER218	electrostatic stabiliser
L	ILE238	electrostatic stabiliser
L	GLY239	electrostatic stabiliser
L	GLY240	electrostatic stabiliser
L	SER241	nucleofuge, nucleophile, proton acceptor, proton donor

---

site_id	MCSA13
Number of Residues	7
Details	M-CSA 731

Chain	Residue	Details
M	LYS142	proton acceptor, proton donor
M	SER217	proton acceptor, proton donor, proton relay
M	SER218	electrostatic stabiliser
M	ILE238	electrostatic stabiliser
M	GLY239	electrostatic stabiliser
M	GLY240	electrostatic stabiliser
M	SER241	nucleofuge, nucleophile, proton acceptor, proton donor

---

site_id	MCSA14
Number of Residues	7
Details	M-CSA 731

Chain	Residue	Details
N	LYS142	proton acceptor, proton donor
N	SER217	proton acceptor, proton donor, proton relay
N	SER218	electrostatic stabiliser
N	ILE238	electrostatic stabiliser
N	GLY239	electrostatic stabiliser
N	GLY240	electrostatic stabiliser
N	SER241	nucleofuge, nucleophile, proton acceptor, proton donor

---

site_id	MCSA15
Number of Residues	7
Details	M-CSA 731

Chain	Residue	Details
O	LYS142	proton acceptor, proton donor
O	SER217	proton acceptor, proton donor, proton relay
O	SER218	electrostatic stabiliser
O	ILE238	electrostatic stabiliser
O	GLY239	electrostatic stabiliser
O	GLY240	electrostatic stabiliser
O	SER241	nucleofuge, nucleophile, proton acceptor, proton donor

---

site_id	MCSA16
Number of Residues	7
Details	M-CSA 731

Chain	Residue	Details
P	LYS142	proton acceptor, proton donor
P	SER217	proton acceptor, proton donor, proton relay
P	SER218	electrostatic stabiliser
P	ILE238	electrostatic stabiliser
P	GLY239	electrostatic stabiliser
P	GLY240	electrostatic stabiliser
P	SER241	nucleofuge, nucleophile, proton acceptor, proton donor

---

site_id	MCSA2
Number of Residues	7
Details	M-CSA 731

Chain	Residue	Details
B	LYS142	proton acceptor, proton donor
B	SER217	proton acceptor, proton donor, proton relay
B	SER218	electrostatic stabiliser
B	ILE238	electrostatic stabiliser
B	GLY239	electrostatic stabiliser
B	GLY240	electrostatic stabiliser
B	SER241	nucleofuge, nucleophile, proton acceptor, proton donor

---

site_id	MCSA3
Number of Residues	7
Details	M-CSA 731

Chain	Residue	Details
C	LYS142	proton acceptor, proton donor
C	SER217	proton acceptor, proton donor, proton relay
C	SER218	electrostatic stabiliser
C	ILE238	electrostatic stabiliser
C	GLY239	electrostatic stabiliser
C	GLY240	electrostatic stabiliser
C	SER241	nucleofuge, nucleophile, proton acceptor, proton donor

---

site_id	MCSA4
Number of Residues	7
Details	M-CSA 731

Chain	Residue	Details
D	LYS142	proton acceptor, proton donor
D	SER217	proton acceptor, proton donor, proton relay
D	SER218	electrostatic stabiliser
D	ILE238	electrostatic stabiliser
D	GLY239	electrostatic stabiliser
D	GLY240	electrostatic stabiliser
D	SER241	nucleofuge, nucleophile, proton acceptor, proton donor

---

site_id	MCSA5
Number of Residues	7
Details	M-CSA 731

Chain	Residue	Details
E	LYS142	proton acceptor, proton donor
E	SER217	proton acceptor, proton donor, proton relay
E	SER218	electrostatic stabiliser
E	ILE238	electrostatic stabiliser
E	GLY239	electrostatic stabiliser
E	GLY240	electrostatic stabiliser
E	SER241	nucleofuge, nucleophile, proton acceptor, proton donor

---

site_id	MCSA6
Number of Residues	7
Details	M-CSA 731

Chain	Residue	Details
F	LYS142	proton acceptor, proton donor
F	SER217	proton acceptor, proton donor, proton relay
F	SER218	electrostatic stabiliser
F	ILE238	electrostatic stabiliser
F	GLY239	electrostatic stabiliser
F	GLY240	electrostatic stabiliser
F	SER241	nucleofuge, nucleophile, proton acceptor, proton donor

---

site_id	MCSA7
Number of Residues	7
Details	M-CSA 731

Chain	Residue	Details
G	LYS142	proton acceptor, proton donor
G	SER217	proton acceptor, proton donor, proton relay
G	SER218	electrostatic stabiliser
G	ILE238	electrostatic stabiliser
G	GLY239	electrostatic stabiliser
G	GLY240	electrostatic stabiliser
G	SER241	nucleofuge, nucleophile, proton acceptor, proton donor

---

site_id	MCSA8
Number of Residues	7
Details	M-CSA 731

Chain	Residue	Details
H	LYS142	proton acceptor, proton donor
H	SER217	proton acceptor, proton donor, proton relay
H	SER218	electrostatic stabiliser
H	ILE238	electrostatic stabiliser
H	GLY239	electrostatic stabiliser
H	GLY240	electrostatic stabiliser
H	SER241	nucleofuge, nucleophile, proton acceptor, proton donor

---

site_id	MCSA9
Number of Residues	7
Details	M-CSA 731

Chain	Residue	Details
I	LYS142	proton acceptor, proton donor
I	SER217	proton acceptor, proton donor, proton relay
I	SER218	electrostatic stabiliser
I	ILE238	electrostatic stabiliser
I	GLY239	electrostatic stabiliser
I	GLY240	electrostatic stabiliser
I	SER241	nucleofuge, nucleophile, proton acceptor, proton donor

---