Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000287 | molecular_function | magnesium ion binding |
A | 0004798 | molecular_function | thymidylate kinase activity |
A | 0005524 | molecular_function | ATP binding |
A | 0005525 | molecular_function | GTP binding |
A | 0005737 | cellular_component | cytoplasm |
A | 0005829 | cellular_component | cytosol |
A | 0006227 | biological_process | dUDP biosynthetic process |
A | 0006233 | biological_process | dTDP biosynthetic process |
A | 0006235 | biological_process | dTTP biosynthetic process |
A | 0009165 | biological_process | nucleotide biosynthetic process |
A | 0016301 | molecular_function | kinase activity |
A | 0042803 | molecular_function | protein homodimerization activity |
A | 0046044 | biological_process | TMP metabolic process |
A | 0046872 | molecular_function | metal ion binding |
A | 0046940 | biological_process | nucleoside monophosphate phosphorylation |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE SO4 A 219 |
Chain | Residue |
A | GLN121 |
A | LYS132 |
A | ALA154 |
A | ARG162 |
A | ARG167 |
A | TRP187 |
A | GLY188 |
A | HOH323 |
site_id | AC2 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE SO4 A 220 |
Chain | Residue |
A | ALA11 |
A | GLY12 |
A | LYS13 |
A | ARG14 |
A | ARG153 |
A | HOH309 |
A | HOH315 |
A | GLY10 |
site_id | AC3 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MG A 300 |
Chain | Residue |
A | ASP9 |
A | GLU166 |
A | 5HU217 |
A | HOH301 |
A | HOH317 |
A | HOH320 |
site_id | AC4 |
Number of Residues | 17 |
Details | BINDING SITE FOR RESIDUE 5HU A 217 |
Chain | Residue |
A | ASP9 |
A | PRO37 |
A | TYR39 |
A | PHE70 |
A | ARG74 |
A | ARG95 |
A | ASN100 |
A | TYR103 |
A | TYR165 |
A | MG300 |
A | HOH301 |
A | HOH310 |
A | HOH316 |
A | HOH317 |
A | HOH320 |
A | HOH325 |
A | HOH359 |
Functional Information from PROSITE/UniProt
site_id | PS01331 |
Number of Residues | 13 |
Details | THYMIDYLATE_KINASE Thymidylate kinase signature. ILDRYvaSNaAYS |
Chain | Residue | Details |
A | ILE92-SER104 | |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 11 |
Details | BINDING: |
Chain | Residue | Details |
A | GLY7 | |
A | TYR165 | |
A | GLU166 | |
A | ASP9 | |
A | TYR39 | |
A | PHE70 | |
A | ARG74 | |
A | ARG95 | |
A | ASN100 | |
A | TYR103 | |
A | ASP163 | |
site_id | SWS_FT_FI2 |
Number of Residues | 1 |
Details | SITE: Transition state stabilizer => ECO:0000255 |
Chain | Residue | Details |
A | ARG153 | |