1MPL
CRYSTAL STRUCTURE OF PHOSPHONATE-INHIBITED D-ALA-D-ALA PEPTIDASE REVEALS AN ANALOG OF A TETRAHEDRAL TRANSITION STATE
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004180 | molecular_function | carboxypeptidase activity |
| A | 0005576 | cellular_component | extracellular region |
| A | 0006508 | biological_process | proteolysis |
| A | 0008233 | molecular_function | peptidase activity |
| A | 0008360 | biological_process | regulation of cell shape |
| A | 0009002 | molecular_function | serine-type D-Ala-D-Ala carboxypeptidase activity |
| A | 0009252 | biological_process | peptidoglycan biosynthetic process |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0071555 | biological_process | cell wall organization |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE RE1 A 400 |
| Chain | Residue |
| A | SER62 |
| A | GLN303 |
| A | SER326 |
| A | ASN327 |
| A | GOL500 |
| A | HOH1013 |
| A | HOH1039 |
| A | HOH1074 |
| A | HOH1087 |
| A | HOH1224 |
| A | ARG99 |
| A | PHE120 |
| A | THR123 |
| A | TYR159 |
| A | ASN161 |
| A | LEU214 |
| A | GLY300 |
| A | THR301 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL A 500 |
| Chain | Residue |
| A | ASP97 |
| A | PRO153 |
| A | TYR306 |
| A | ASN327 |
| A | VAL329 |
| A | RE1400 |
| A | HOH1107 |
| A | HOH1237 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE GOL A 501 |
| Chain | Residue |
| A | SER86 |
| A | THR89 |
| A | ASP98 |
| A | ARG99 |
| A | ASP114 |
| A | ASN117 |
| A | TYR159 |
| A | HOH1034 |
| A | HOH1064 |
| A | HOH1221 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 502 |
| Chain | Residue |
| A | TYR137 |
| A | GLU172 |
| A | HIS200 |
| A | HOH1025 |
| A | HOH1049 |
| A | HOH1352 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL A 503 |
| Chain | Residue |
| A | ILE205 |
| A | GLY207 |
| A | HIS209 |
| A | LYS346 |
| A | HOH1045 |
| A | HOH1223 |
| A | HOH1299 |
| site_id | AC6 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE GOL A 504 |
| Chain | Residue |
| A | PRO6 |
| A | ASP7 |
| A | ASP8 |
| A | HIS209 |
| A | ASN211 |
| A | THR227 |
| A | GLU228 |
| A | LYS346 |
| A | HOH1109 |
| A | HOH1409 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Acyl-ester intermediate","evidences":[{"source":"PubMed","id":"12215418","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12564922","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15581896","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 9 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"12215418","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12564922","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15581896","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 5 |
| Details | Annotated By Reference To The Literature 1ei5 |
| Chain | Residue | Details |
| A | HIS298 | |
| A | SER62 | |
| A | ASN161 | |
| A | LYS65 | |
| A | TYR159 |
