Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004222 | molecular_function | metalloendopeptidase activity |
A | 0006508 | biological_process | proteolysis |
A | 0008237 | molecular_function | metallopeptidase activity |
A | 0008270 | molecular_function | zinc ion binding |
A | 0031012 | cellular_component | extracellular matrix |
B | 0004222 | molecular_function | metalloendopeptidase activity |
B | 0006508 | biological_process | proteolysis |
B | 0008237 | molecular_function | metallopeptidase activity |
B | 0008270 | molecular_function | zinc ion binding |
B | 0031012 | cellular_component | extracellular matrix |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN A 1 |
Chain | Residue |
A | HIS218 |
A | HIS222 |
A | HIS228 |
A | RSS269 |
site_id | AC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN A 2 |
Chain | Residue |
A | HIS168 |
A | ASP170 |
A | HIS183 |
A | HIS196 |
site_id | AC3 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CA A 3 |
Chain | Residue |
A | GLY190 |
A | GLY192 |
A | ASP194 |
A | HOH313 |
A | HOH369 |
A | ASP158 |
site_id | AC4 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CA A 4 |
Chain | Residue |
A | ASP175 |
A | GLY176 |
A | GLY178 |
A | THR180 |
A | ASP198 |
A | GLU201 |
site_id | AC5 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN B 1 |
Chain | Residue |
B | HIS218 |
B | HIS222 |
B | HIS228 |
B | RSS269 |
site_id | AC6 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN B 2 |
Chain | Residue |
B | HIS168 |
B | ASP170 |
B | HIS183 |
B | HIS196 |
site_id | AC7 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE CA B 3 |
Chain | Residue |
B | ASP158 |
B | GLY190 |
B | GLY192 |
B | ASP194 |
B | HOH341 |
site_id | AC8 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CA B 4 |
Chain | Residue |
B | ASP175 |
B | GLY176 |
B | GLY178 |
B | THR180 |
B | ASP198 |
B | GLU201 |
site_id | AC9 |
Number of Residues | 14 |
Details | BINDING SITE FOR RESIDUE RSS A 269 |
Chain | Residue |
A | ZN1 |
A | ASN179 |
A | LEU181 |
A | ALA182 |
A | HIS218 |
A | GLU219 |
A | HIS222 |
A | HIS228 |
A | PRO238 |
A | THR239 |
A | TYR240 |
A | HOH318 |
B | PRO232 |
B | ASN242 |
site_id | BC1 |
Number of Residues | 16 |
Details | BINDING SITE FOR RESIDUE RSS B 269 |
Chain | Residue |
A | PRO232 |
A | ASN242 |
B | ZN1 |
B | ASN179 |
B | LEU181 |
B | ALA182 |
B | HIS218 |
B | GLU219 |
B | HIS222 |
B | HIS228 |
B | PRO238 |
B | THR239 |
B | TYR240 |
B | HOH352 |
B | HOH353 |
B | HOH355 |
Functional Information from PROSITE/UniProt
site_id | PS00142 |
Number of Residues | 10 |
Details | ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. AATHELGHSL |
Chain | Residue | Details |
A | ALA215-LEU224 | |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | ACT_SITE: |
Chain | Residue | Details |
A | GLU219 | |
B | GLU219 | |
site_id | SWS_FT_FI2 |
Number of Residues | 34 |
Details | BINDING: |
Chain | Residue | Details |
A | ASP158 | |
A | GLY192 | |
A | ASP194 | |
A | HIS196 | |
A | ASP198 | |
A | GLU201 | |
A | HIS218 | |
A | HIS222 | |
A | HIS228 | |
B | ASP158 | |
B | HIS168 | |
A | HIS168 | |
B | ASP170 | |
B | ASP175 | |
B | GLY176 | |
B | GLY178 | |
B | THR180 | |
B | HIS183 | |
B | GLY190 | |
B | GLY192 | |
B | ASP194 | |
B | HIS196 | |
A | ASP170 | |
B | ASP198 | |
B | GLU201 | |
B | HIS218 | |
B | HIS222 | |
B | HIS228 | |
A | ASP175 | |
A | GLY176 | |
A | GLY178 | |
A | THR180 | |
A | HIS183 | |
A | GLY190 | |