1MLA

THE ESCHERICHIA COLI MALONYL-COA:ACYL CARRIER PROTEIN TRANSACYLASE AT 1.5-ANGSTROMS RESOLUTION. CRYSTAL STRUCTURE OF A FATTY ACID SYNTHASE COMPONENT

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004314	molecular_function	[acyl-carrier-protein] S-malonyltransferase activity
A	0005829	cellular_component	cytosol
A	0006633	biological_process	fatty acid biosynthetic process
A	0016740	molecular_function	transferase activity

Functional Information from PDB Data

site_id	CAT
Number of Residues	2
Details	CATALYTIC DYAD

Chain	Residue
A	SER92
A	HIS201

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"evidences":[{"source":"PubMed","id":"7768883","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	a catalytic site defined by CSA, PubMed 7768883

Chain	Residue	Details
A	SER92
A	HIS201
A	GLN250

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site_id	MCSA1
Number of Residues	6
Details	M-CSA 291

Chain	Residue	Details
A	GLN11	electrostatic stabiliser, hydrogen bond donor
A	SER92	activator, covalently attached, hydrogen bond acceptor, hydrogen bond donor, nucleofuge, nucleophile, proton acceptor, proton donor
A	LEU93	electrostatic stabiliser, hydrogen bond donor
A	ARG117	attractive charge-charge interaction, electrostatic stabiliser, hydrogen bond donor
A	HIS201	hydrogen bond acceptor, hydrogen bond donor, increase nucleophilicity, proton acceptor, proton donor
A	GLN250	electrostatic stabiliser, hydrogen bond acceptor, increase basicity

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