1MJQ

METHIONINE REPRESSOR MUTANT (Q44K) PLUS COREPRESSOR (S-ADENOSYL METHIONINE) COMPLEXED TO AN ALTERED MET CONSENSUS OPERATOR SEQUENCE

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003700	molecular_function	DNA-binding transcription factor activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006355	biological_process	regulation of DNA-templated transcription
A	0006555	biological_process	methionine metabolic process
A	0009086	biological_process	methionine biosynthetic process
A	0045892	biological_process	negative regulation of DNA-templated transcription
B	0003677	molecular_function	DNA binding
B	0003700	molecular_function	DNA-binding transcription factor activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006355	biological_process	regulation of DNA-templated transcription
B	0006555	biological_process	methionine metabolic process
B	0009086	biological_process	methionine biosynthetic process
B	0045892	biological_process	negative regulation of DNA-templated transcription
C	0003677	molecular_function	DNA binding
C	0003700	molecular_function	DNA-binding transcription factor activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006355	biological_process	regulation of DNA-templated transcription
C	0006555	biological_process	methionine metabolic process
C	0009086	biological_process	methionine biosynthetic process
C	0045892	biological_process	negative regulation of DNA-templated transcription
D	0003677	molecular_function	DNA binding
D	0003700	molecular_function	DNA-binding transcription factor activity
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006355	biological_process	regulation of DNA-templated transcription
D	0006555	biological_process	methionine metabolic process
D	0009086	biological_process	methionine biosynthetic process
D	0045892	biological_process	negative regulation of DNA-templated transcription
G	0003677	molecular_function	DNA binding
G	0003700	molecular_function	DNA-binding transcription factor activity
G	0005515	molecular_function	protein binding
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0006355	biological_process	regulation of DNA-templated transcription
G	0006555	biological_process	methionine metabolic process
G	0009086	biological_process	methionine biosynthetic process
G	0045892	biological_process	negative regulation of DNA-templated transcription
H	0003677	molecular_function	DNA binding
H	0003700	molecular_function	DNA-binding transcription factor activity
H	0005515	molecular_function	protein binding
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0006355	biological_process	regulation of DNA-templated transcription
H	0006555	biological_process	methionine metabolic process
H	0009086	biological_process	methionine biosynthetic process
H	0045892	biological_process	negative regulation of DNA-templated transcription
I	0003677	molecular_function	DNA binding
I	0003700	molecular_function	DNA-binding transcription factor activity
I	0005515	molecular_function	protein binding
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0006355	biological_process	regulation of DNA-templated transcription
I	0006555	biological_process	methionine metabolic process
I	0009086	biological_process	methionine biosynthetic process
I	0045892	biological_process	negative regulation of DNA-templated transcription
J	0003677	molecular_function	DNA binding
J	0003700	molecular_function	DNA-binding transcription factor activity
J	0005515	molecular_function	protein binding
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0006355	biological_process	regulation of DNA-templated transcription
J	0006555	biological_process	methionine metabolic process
J	0009086	biological_process	methionine biosynthetic process
J	0045892	biological_process	negative regulation of DNA-templated transcription

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	BINDING SITE FOR RESIDUE SAM A 200

Chain	Residue
A	GLU39
B	PHE61
B	HIS63
B	ALA64
B	PHE65
B	GLY67
A	ARG43
A	LEU56
A	GLU59
A	ALA60
A	HIS63
A	LEU70
A	PRO71
A	HOH1314

---

site_id	AC2
Number of Residues	14
Details	BINDING SITE FOR RESIDUE SAM B 200

Chain	Residue
A	GLU2
A	PHE61
A	HIS63
A	ALA64
A	PHE65
A	GLY67
B	GLU39
B	ARG43
B	LEU56
B	GLU59
B	HIS63
B	LEU70
B	PRO71
B	HOH311

---

site_id	AC3
Number of Residues	13
Details	BINDING SITE FOR RESIDUE SAM C 199

Chain	Residue
C	GLU39
C	ARG43
C	LEU56
C	GLU59
C	HIS63
C	LEU70
C	PRO71
C	HOH3311
D	PHE61
D	HIS63
D	ALA64
D	PHE65
D	GLY67

---

site_id	AC4
Number of Residues	14
Details	BINDING SITE FOR RESIDUE SAM D 200

Chain	Residue
C	PHE61
C	HIS63
C	ALA64
C	PHE65
C	GLY67
D	GLU39
D	ARG43
D	LEU56
D	GLU59
D	ALA60
D	HIS63
D	LEU70
D	PRO71
D	HOH3304

---

site_id	AC5
Number of Residues	13
Details	BINDING SITE FOR RESIDUE SAM G 199

Chain	Residue
G	GLU39
G	ARG43
G	LEU56
G	GLU59
G	ALA60
G	HIS63
G	LEU70
G	PRO71
G	HOH7313
H	PHE61
H	HIS63
H	ALA64
H	PHE65

---

site_id	AC6
Number of Residues	12
Details	BINDING SITE FOR RESIDUE SAM H 200

Chain	Residue
G	PHE61
G	HIS63
G	ALA64
G	PHE65
G	GLY67
H	GLU39
H	ARG43
H	LEU56
H	GLU59
H	HIS63
H	LEU70
H	PRO71

---

site_id	AC7
Number of Residues	12
Details	BINDING SITE FOR RESIDUE SAM I 199

Chain	Residue
I	GLU39
I	ARG43
I	LEU56
I	GLU59
I	ALA60
I	HIS63
I	LEU70
I	PRO71
J	PHE61
J	HIS63
J	ALA64
J	PHE65

---

site_id	AC8
Number of Residues	12
Details	BINDING SITE FOR RESIDUE SAM J 200

Chain	Residue
J	GLU59
J	ALA60
J	HIS63
J	LEU70
J	PRO71
I	PHE61
I	HIS63
I	ALA64
I	PHE65
J	GLU39
J	ARG43
J	LEU56

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