1MJ2

METHIONINE REPRESSOR MUTANT (Q44K) PLUS COREPRESSOR (S-ADENOSYL METHIONINE) COMPLEXED TO A CONSENSUS OPERATOR SEQUENCE

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003700	molecular_function	DNA-binding transcription factor activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006355	biological_process	regulation of DNA-templated transcription
A	0006555	biological_process	methionine metabolic process
A	0009086	biological_process	methionine biosynthetic process
A	0045892	biological_process	negative regulation of DNA-templated transcription
B	0003677	molecular_function	DNA binding
B	0003700	molecular_function	DNA-binding transcription factor activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006355	biological_process	regulation of DNA-templated transcription
B	0006555	biological_process	methionine metabolic process
B	0009086	biological_process	methionine biosynthetic process
B	0045892	biological_process	negative regulation of DNA-templated transcription
C	0003677	molecular_function	DNA binding
C	0003700	molecular_function	DNA-binding transcription factor activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006355	biological_process	regulation of DNA-templated transcription
C	0006555	biological_process	methionine metabolic process
C	0009086	biological_process	methionine biosynthetic process
C	0045892	biological_process	negative regulation of DNA-templated transcription
D	0003677	molecular_function	DNA binding
D	0003700	molecular_function	DNA-binding transcription factor activity
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006355	biological_process	regulation of DNA-templated transcription
D	0006555	biological_process	methionine metabolic process
D	0009086	biological_process	methionine biosynthetic process
D	0045892	biological_process	negative regulation of DNA-templated transcription

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA B 1202

Chain	Residue
A	GLU90
A	GLU94
B	GLU90
B	GLU94
B	HOH3331

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site_id	AC2
Number of Residues	16
Details	BINDING SITE FOR RESIDUE SAM A 2200

Chain	Residue
A	GLY67
A	HOH3215
A	HOH3352
B	GLU39
B	ARG43
B	LEU56
B	GLU59
B	HIS63
B	PRO71
B	HOH3303
B	HOH3309
B	HOH3347
A	PHE61
A	HIS63
A	ALA64
A	PHE65

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site_id	AC3
Number of Residues	17
Details	BINDING SITE FOR RESIDUE SAM A 2201

Chain	Residue
A	GLU39
A	ARG43
A	LEU56
A	GLU59
A	ALA60
A	HIS63
A	PRO71
A	HOH3210
A	HOH3250
A	HOH3305
A	HOH3327
A	HOH3352
B	PHE61
B	HIS63
B	ALA64
B	PHE65
B	GLY67

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site_id	AC4
Number of Residues	16
Details	BINDING SITE FOR RESIDUE SAM C 1200

Chain	Residue
C	GLU39
C	ARG43
C	LEU56
C	GLU59
C	ALA60
C	HIS63
C	PRO71
C	HOH4322
C	HOH4333
D	PHE61
D	HIS63
D	ALA64
D	PHE65
D	GLY67
D	HOH5322
D	HOH5326

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site_id	AC5
Number of Residues	12
Details	BINDING SITE FOR RESIDUE SAM C 2199

Chain	Residue
C	PHE61
C	HIS63
C	ALA64
C	PHE65
C	GLY67
D	GLU39
D	ARG43
D	LEU56
D	GLU59
D	HIS63
D	LEU70
D	PRO71

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