1MHZ
METHANE MONOOXYGENASE HYDROXYLASE
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016709 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen |
| D | 0016491 | molecular_function | oxidoreductase activity |
| G | 0004497 | molecular_function | monooxygenase activity |
| G | 0006730 | biological_process | one-carbon metabolic process |
| G | 0015049 | molecular_function | methane monooxygenase [NAD(P)H] activity |
| G | 0015947 | biological_process | methane metabolic process |
| G | 0016491 | molecular_function | oxidoreductase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE FE D 801 |
| Chain | Residue |
| D | GLU114 |
| D | GLU144 |
| D | HIS147 |
| D | FE802 |
| D | HOH803 |
| D | HOH804 |
| D | HOH805 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE FE D 802 |
| Chain | Residue |
| D | GLU144 |
| D | GLU209 |
| D | GLU243 |
| D | HIS246 |
| D | FE801 |
| D | HOH803 |
| D | HOH804 |
| site_id | FE2 |
| Number of Residues | 11 |
| Details | THE PROPOSED ACTIVE SITE FOR THIS ENZYME CONSISTS OF BIS-MU-OXO BRIDGED DIIRONS LIGATED TO RESIDUES D 114, D 144, D 147, D 209, D 243, D 246, HOH 1, HOH 2, AND HOH 3. |
| Chain | Residue |
| D | FE801 |
| D | HIS147 |
| D | HIS246 |
| D | FE802 |
| D | HOH803 |
| D | HOH804 |
| D | HOH805 |
| D | GLU114 |
| D | GLU144 |
| D | GLU209 |
| D | GLU243 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1mhy |
| Chain | Residue | Details |
| D | CYS151 | |
| D | THR213 |
| site_id | MCSA1 |
| Number of Residues | 6 |
| Details | M-CSA 600 |
| Chain | Residue | Details |
| B | HIS109 | metal ligand |
| B | ILE139 | metal ligand |
| B | TYR142 | metal ligand |
| B | ALA204 | metal ligand |
| B | TRP238 | hydrogen bond donor, metal ligand |
| B | VAL241 | metal ligand |
