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1MFI

CRYSTAL STRUCTURE OF MACROPHAGE MIGRATION INHIBITORY FACTOR COMPLEXED WITH (E)-2-FLUORO-P-HYDROXYCINNAMATE

Functional Information from GO Data
ChainGOidnamespacecontents
A0001516biological_processprostaglandin biosynthetic process
A0001819biological_processpositive regulation of cytokine production
A0001934biological_processpositive regulation of protein phosphorylation
A0002020molecular_functionprotease binding
A0002821biological_processpositive regulation of adaptive immune response
A0002906biological_processnegative regulation of mature B cell apoptotic process
A0004167molecular_functiondopachrome isomerase activity
A0005125molecular_functioncytokine activity
A0005126molecular_functioncytokine receptor binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0006954biological_processinflammatory response
A0007166biological_processcell surface receptor signaling pathway
A0008284biological_processpositive regulation of cell population proliferation
A0009986cellular_componentcell surface
A0010629biological_processnegative regulation of gene expression
A0010739biological_processpositive regulation of protein kinase A signaling
A0010760biological_processnegative regulation of macrophage chemotaxis
A0016853molecular_functionisomerase activity
A0019752biological_processcarboxylic acid metabolic process
A0030330biological_processDNA damage response, signal transduction by p53 class mediator
A0030336biological_processnegative regulation of cell migration
A0030890biological_processpositive regulation of B cell proliferation
A0031666biological_processpositive regulation of lipopolysaccharide-mediated signaling pathway
A0032760biological_processpositive regulation of tumor necrosis factor production
A0033033biological_processnegative regulation of myeloid cell apoptotic process
A0033138biological_processpositive regulation of peptidyl-serine phosphorylation
A0042056molecular_functionchemoattractant activity
A0042127biological_processregulation of cell population proliferation
A0042327biological_processpositive regulation of phosphorylation
A0042802molecular_functionidentical protein binding
A0043066biological_processnegative regulation of apoptotic process
A0043209cellular_componentmyelin sheath
A0043406biological_processpositive regulation of MAP kinase activity
A0043518biological_processnegative regulation of DNA damage response, signal transduction by p53 class mediator
A0044877molecular_functionprotein-containing complex binding
A0045087biological_processinnate immune response
A0048146biological_processpositive regulation of fibroblast proliferation
A0050178molecular_functionphenylpyruvate tautomerase activity
A0050731biological_processpositive regulation of peptidyl-tyrosine phosphorylation
A0050918biological_processpositive chemotaxis
A0051248biological_processnegative regulation of protein metabolic process
A0061078biological_processpositive regulation of prostaglandin secretion involved in immune response
A0061081biological_processpositive regulation of myeloid leukocyte cytokine production involved in immune response
A0070207biological_processprotein homotrimerization
A0070374biological_processpositive regulation of ERK1 and ERK2 cascade
A0090238biological_processpositive regulation of arachidonic acid secretion
A0090398biological_processcellular senescence
A1902166biological_processnegative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
A2000343biological_processpositive regulation of chemokine (C-X-C motif) ligand 2 production
A2000773biological_processnegative regulation of cellular senescence
B0001516biological_processprostaglandin biosynthetic process
B0001819biological_processpositive regulation of cytokine production
B0001934biological_processpositive regulation of protein phosphorylation
B0002020molecular_functionprotease binding
B0002821biological_processpositive regulation of adaptive immune response
B0002906biological_processnegative regulation of mature B cell apoptotic process
B0004167molecular_functiondopachrome isomerase activity
B0005125molecular_functioncytokine activity
B0005126molecular_functioncytokine receptor binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0006954biological_processinflammatory response
B0007166biological_processcell surface receptor signaling pathway
B0008284biological_processpositive regulation of cell population proliferation
B0009986cellular_componentcell surface
B0010629biological_processnegative regulation of gene expression
B0010739biological_processpositive regulation of protein kinase A signaling
B0010760biological_processnegative regulation of macrophage chemotaxis
B0016853molecular_functionisomerase activity
B0019752biological_processcarboxylic acid metabolic process
B0030330biological_processDNA damage response, signal transduction by p53 class mediator
B0030336biological_processnegative regulation of cell migration
B0030890biological_processpositive regulation of B cell proliferation
B0031666biological_processpositive regulation of lipopolysaccharide-mediated signaling pathway
B0032760biological_processpositive regulation of tumor necrosis factor production
B0033033biological_processnegative regulation of myeloid cell apoptotic process
B0033138biological_processpositive regulation of peptidyl-serine phosphorylation
B0042056molecular_functionchemoattractant activity
B0042127biological_processregulation of cell population proliferation
B0042327biological_processpositive regulation of phosphorylation
B0042802molecular_functionidentical protein binding
B0043066biological_processnegative regulation of apoptotic process
B0043209cellular_componentmyelin sheath
B0043406biological_processpositive regulation of MAP kinase activity
B0043518biological_processnegative regulation of DNA damage response, signal transduction by p53 class mediator
B0044877molecular_functionprotein-containing complex binding
B0045087biological_processinnate immune response
B0048146biological_processpositive regulation of fibroblast proliferation
B0050178molecular_functionphenylpyruvate tautomerase activity
B0050731biological_processpositive regulation of peptidyl-tyrosine phosphorylation
B0050918biological_processpositive chemotaxis
B0051248biological_processnegative regulation of protein metabolic process
B0061078biological_processpositive regulation of prostaglandin secretion involved in immune response
B0061081biological_processpositive regulation of myeloid leukocyte cytokine production involved in immune response
B0070207biological_processprotein homotrimerization
B0070374biological_processpositive regulation of ERK1 and ERK2 cascade
B0090238biological_processpositive regulation of arachidonic acid secretion
B0090398biological_processcellular senescence
B1902166biological_processnegative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
B2000343biological_processpositive regulation of chemokine (C-X-C motif) ligand 2 production
B2000773biological_processnegative regulation of cellular senescence
C0001516biological_processprostaglandin biosynthetic process
C0001819biological_processpositive regulation of cytokine production
C0001934biological_processpositive regulation of protein phosphorylation
C0002020molecular_functionprotease binding
C0002821biological_processpositive regulation of adaptive immune response
C0002906biological_processnegative regulation of mature B cell apoptotic process
C0004167molecular_functiondopachrome isomerase activity
C0005125molecular_functioncytokine activity
C0005126molecular_functioncytokine receptor binding
C0005576cellular_componentextracellular region
C0005615cellular_componentextracellular space
C0005654cellular_componentnucleoplasm
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0005886cellular_componentplasma membrane
C0006954biological_processinflammatory response
C0007166biological_processcell surface receptor signaling pathway
C0008284biological_processpositive regulation of cell population proliferation
C0009986cellular_componentcell surface
C0010629biological_processnegative regulation of gene expression
C0010739biological_processpositive regulation of protein kinase A signaling
C0010760biological_processnegative regulation of macrophage chemotaxis
C0016853molecular_functionisomerase activity
C0019752biological_processcarboxylic acid metabolic process
C0030330biological_processDNA damage response, signal transduction by p53 class mediator
C0030336biological_processnegative regulation of cell migration
C0030890biological_processpositive regulation of B cell proliferation
C0031666biological_processpositive regulation of lipopolysaccharide-mediated signaling pathway
C0032760biological_processpositive regulation of tumor necrosis factor production
C0033033biological_processnegative regulation of myeloid cell apoptotic process
C0033138biological_processpositive regulation of peptidyl-serine phosphorylation
C0042056molecular_functionchemoattractant activity
C0042127biological_processregulation of cell population proliferation
C0042327biological_processpositive regulation of phosphorylation
C0042802molecular_functionidentical protein binding
C0043066biological_processnegative regulation of apoptotic process
C0043209cellular_componentmyelin sheath
C0043406biological_processpositive regulation of MAP kinase activity
C0043518biological_processnegative regulation of DNA damage response, signal transduction by p53 class mediator
C0044877molecular_functionprotein-containing complex binding
C0045087biological_processinnate immune response
C0048146biological_processpositive regulation of fibroblast proliferation
C0050178molecular_functionphenylpyruvate tautomerase activity
C0050731biological_processpositive regulation of peptidyl-tyrosine phosphorylation
C0050918biological_processpositive chemotaxis
C0051248biological_processnegative regulation of protein metabolic process
C0061078biological_processpositive regulation of prostaglandin secretion involved in immune response
C0061081biological_processpositive regulation of myeloid leukocyte cytokine production involved in immune response
C0070207biological_processprotein homotrimerization
C0070374biological_processpositive regulation of ERK1 and ERK2 cascade
C0090238biological_processpositive regulation of arachidonic acid secretion
C0090398biological_processcellular senescence
C1902166biological_processnegative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
C2000343biological_processpositive regulation of chemokine (C-X-C motif) ligand 2 production
C2000773biological_processnegative regulation of cellular senescence
Functional Information from PDB Data
site_idAC1
Number of Residues10
DetailsBINDING SITE FOR RESIDUE FHC A 115
ChainResidue
APRO1
CASN97
AMET2
ALYS32
ATYR36
AHIS62
AILE64
AMET101
AHOH231
CTYR95

site_idAC2
Number of Residues11
DetailsBINDING SITE FOR RESIDUE FHC B 116
ChainResidue
ATYR95
AASN97
BPRO1
BMET2
BLYS32
BTYR36
BHIS62
BILE64
BMET101
BVAL106
BPHE113

site_idAC3
Number of Residues11
DetailsBINDING SITE FOR RESIDUE FHC C 117
ChainResidue
BTYR95
BASN97
CPRO1
CMET2
CLYS32
CTYR36
CHIS62
CSER63
CILE64
CMET101
CVAL106

Functional Information from PROSITE/UniProt
site_idPS01158
Number of Residues15
DetailsMIF Macrophage migration inhibitory factor family signature. DPCAlcsLhSIGkIG
ChainResidueDetails
AASP54-GLY68

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3
DetailsACT_SITE: Proton acceptor; via imino nitrogen => ECO:0000269|PubMed:10933783, ECO:0000269|PubMed:19188446
ChainResidueDetails
AMET2
BMET2
CMET2

site_idSWS_FT_FI2
Number of Residues6
DetailsBINDING: BINDING => ECO:0000269|PubMed:16780921
ChainResidueDetails
APRO33
ATYR98
BPRO33
BTYR98
CPRO33
CTYR98

site_idSWS_FT_FI3
Number of Residues3
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:P14174
ChainResidueDetails
AGLY65
BGLY65
CGLY65

site_idSWS_FT_FI4
Number of Residues3
DetailsMOD_RES: N6-succinyllysine; alternate => ECO:0007744|PubMed:23806337
ChainResidueDetails
ALEU78
BLEU78
CLEU78

219140

PDB entries from 2024-05-01

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