1MDM

INHIBITED FRAGMENT OF ETS-1 AND PAIRED DOMAIN OF PAX5 BOUND TO DNA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0006355	biological_process	regulation of DNA-templated transcription
B	0003700	molecular_function	DNA-binding transcription factor activity
B	0006355	biological_process	regulation of DNA-templated transcription
B	0006357	biological_process	regulation of transcription by RNA polymerase II
B	0043565	molecular_function	sequence-specific DNA binding

Functional Information from PROSITE/UniProt

site_id	PS00034
Number of Residues	17
Details	PAIRED_1 Paired DNA-binding domain signature. RPCdisrqlrvshgCVS

Chain	Residue	Details
A	ARG50-SER66

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site_id	PS00345
Number of Residues	9
Details	ETS_DOMAIN_1 Ets-domain signature 1. LWQFLLELL

Chain	Residue	Details
B	LEU337-LEU345

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site_id	PS00346
Number of Residues	16
Details	ETS_DOMAIN_2 Ets-domain signature 2. KpkMnYEkLSRGLRyY

Chain	Residue	Details
B	LYS381-TYR396

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	80
Details	DNA_BIND: ETS => ECO:0000255|PROSITE-ProRule:PRU00237

Chain	Residue	Details
B	ILE335-VAL415

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site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: Phosphoserine; by CaMK2 => ECO:0000269|PubMed:15994560, ECO:0007744|PubMed:21183079

Chain	Residue	Details
B	SER282
B	SER285

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P14921

Chain	Residue	Details
B	LYS305

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