1MC8

Crystal Structure of Flap Endonuclease-1 R42E mutant from Pyrococcus horikoshii

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0003677	molecular_function	DNA binding
A	0003824	molecular_function	catalytic activity
A	0004518	molecular_function	nuclease activity
A	0004519	molecular_function	endonuclease activity
A	0004527	molecular_function	exonuclease activity
A	0006260	biological_process	DNA replication
A	0006281	biological_process	DNA repair
A	0008409	molecular_function	5'-3' exonuclease activity
A	0016788	molecular_function	hydrolase activity, acting on ester bonds
A	0017108	molecular_function	5'-flap endonuclease activity
A	0043137	biological_process	DNA replication, removal of RNA primer
A	0046872	molecular_function	metal ion binding
B	0000287	molecular_function	magnesium ion binding
B	0003677	molecular_function	DNA binding
B	0003824	molecular_function	catalytic activity
B	0004518	molecular_function	nuclease activity
B	0004519	molecular_function	endonuclease activity
B	0004527	molecular_function	exonuclease activity
B	0006260	biological_process	DNA replication
B	0006281	biological_process	DNA repair
B	0008409	molecular_function	5'-3' exonuclease activity
B	0016788	molecular_function	hydrolase activity, acting on ester bonds
B	0017108	molecular_function	5'-flap endonuclease activity
B	0043137	biological_process	DNA replication, removal of RNA primer
B	0046872	molecular_function	metal ion binding

Functional Information from PROSITE/UniProt

site_id	PS00841
Number of Residues	15
Details	XPG_1 XPG protein signature 1. IKPaYVFDGkpPeFK

Chain	Residue	Details
A	ILE73-LYS87

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	14
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00614

Chain	Residue	Details
A	ASP27
B	GLU152
B	GLU154
B	ASP173
B	ASP175
B	ASP236
A	ASP80
A	GLU152
A	GLU154
A	ASP173
A	ASP175
A	ASP236
B	ASP27
B	ASP80

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1exn

Chain	Residue	Details
A	ARG95

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site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1exn

Chain	Residue	Details
B	ARG95

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