1MAT

STRUCTURE OF THE COBALT-DEPENDENT METHIONINE AMINOPEPTIDASE FROM ESCHERICHIA COLI: A NEW TYPE OF PROTEOLYTIC ENZYME

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004177	molecular_function	aminopeptidase activity
A	0004239	molecular_function	initiator methionyl aminopeptidase activity
A	0005829	cellular_component	cytosol
A	0006508	biological_process	proteolysis
A	0008198	molecular_function	ferrous iron binding
A	0008235	molecular_function	metalloexopeptidase activity
A	0046872	molecular_function	metal ion binding
A	0070006	molecular_function	metalloaminopeptidase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CO A 401

Chain	Residue
A	THR202
A	GLU204
A	GLU235
A	CO402
A	ASP108
A	HIS171

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site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CO A 402

Chain	Residue
A	ASP97
A	ASP108
A	GLU235
A	CO401

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site_id	ACT
Number of Residues	7
Details

Chain	Residue
A	ASP97
A	ASP108
A	HIS171
A	GLU204
A	GLU235
A	CO401
A	ALA2

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Functional Information from PROSITE/UniProt

site_id	PS00680
Number of Residues	19
Details	MAP_1 Methionine aminopeptidase subfamily 1 signature. YcGHGIGrgfHeepqVl.HY

Chain	Residue	Details
A	TYR168-TYR186

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01974, ECO:0000269|PubMed:10555963, ECO:0000269|PubMed:16769889, ECO:0000269|PubMed:17120228

Chain	Residue	Details
A	HIS79
A	HIS178

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site_id	SWS_FT_FI2
Number of Residues	5
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01974, ECO:0000269|PubMed:10387007, ECO:0000269|PubMed:10555963, ECO:0000269|PubMed:16769889, ECO:0000269|PubMed:17120228, ECO:0000269|PubMed:18093325, ECO:0000269|PubMed:18785729

Chain	Residue	Details
A	ASP97
A	ASP108
A	HIS171
A	GLU204
A	GLU235

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site_id	SWS_FT_FI3
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:10555963, ECO:0000269|PubMed:16769889, ECO:0000269|PubMed:17120228

Chain	Residue	Details
A	THR99

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1a16

Chain	Residue	Details
A	GLU204
A	GLN182

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site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1a16

Chain	Residue	Details
A	GLU204

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