1MAS
PURINE NUCLEOSIDE HYDROLASE
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005829 | cellular_component | cytosol |
| A | 0006152 | biological_process | purine nucleoside catabolic process |
| A | 0008477 | molecular_function | purine nucleosidase activity |
| A | 0009117 | biological_process | nucleotide metabolic process |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
| A | 0016799 | molecular_function | hydrolase activity, hydrolyzing N-glycosyl compounds |
| A | 0045437 | molecular_function | uridine nucleosidase activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0047724 | molecular_function | inosine nucleosidase activity |
| B | 0005829 | cellular_component | cytosol |
| B | 0006152 | biological_process | purine nucleoside catabolic process |
| B | 0008477 | molecular_function | purine nucleosidase activity |
| B | 0009117 | biological_process | nucleotide metabolic process |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
| B | 0016799 | molecular_function | hydrolase activity, hydrolyzing N-glycosyl compounds |
| B | 0045437 | molecular_function | uridine nucleosidase activity |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0047724 | molecular_function | inosine nucleosidase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE K A 900 |
| Chain | Residue |
| A | ASP10 |
| A | ASP15 |
| A | THR126 |
| A | ASP242 |
| A | HOH902 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE K B 933 |
| Chain | Residue |
| B | ASP10 |
| B | ASP15 |
| B | THR126 |
| B | ASP242 |
| site_id | ACT |
| Number of Residues | 10 |
| Details | POCKET AT THE C-TERMINAL END OF THE BETA SHEET. |
| Chain | Residue |
| A | ASP10 |
| B | ASP242 |
| A | ASP14 |
| A | ASP15 |
| A | HIS241 |
| A | ASP242 |
| B | ASP10 |
| B | ASP14 |
| B | ASP15 |
| B | HIS241 |
Functional Information from PROSITE/UniProt
| site_id | PS01247 |
| Number of Residues | 11 |
| Details | IUNH Inosine-uridine preferring nucleoside hydrolase family signature. DcDPGlDDAVA |
| Chain | Residue | Details |
| A | ASP8-ALA18 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton donor","evidences":[{"source":"PubMed","id":"8634238","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"8634238","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | a catalytic site defined by CSA, PubMed 9572842, 8634238, 8634237, 12137535 |
| Chain | Residue | Details |
| A | ASP10 | |
| A | HIS241 | |
| A | ASN168 |
| site_id | CSA2 |
| Number of Residues | 3 |
| Details | a catalytic site defined by CSA, PubMed 9572842, 8634238, 8634237, 12137535 |
| Chain | Residue | Details |
| B | ASP10 | |
| B | HIS241 | |
| B | ASN168 |
| site_id | MCSA1 |
| Number of Residues | 8 |
| Details | M-CSA 39 |
| Chain | Residue | Details |
| A | ASP10 | hydrogen bond acceptor, hydrogen bond donor, metal ligand, proton acceptor, proton donor |
| A | ASP15 | metal ligand |
| A | ASN39 | metal ligand |
| A | THR126 | metal ligand |
| A | PHE167 | electrostatic stabiliser |
| A | ASN168 | electrostatic stabiliser, hydrogen bond donor |
| A | HIS241 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| A | ASP242 | metal ligand |
| site_id | MCSA2 |
| Number of Residues | 8 |
| Details | M-CSA 39 |
| Chain | Residue | Details |
| B | ASP10 | hydrogen bond acceptor, hydrogen bond donor, metal ligand, proton acceptor, proton donor |
| B | ASP15 | metal ligand |
| B | ASN39 | metal ligand |
| B | THR126 | metal ligand |
| B | PHE167 | electrostatic stabiliser |
| B | ASN168 | electrostatic stabiliser, hydrogen bond donor |
| B | HIS241 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| B | ASP242 | metal ligand |
