1M7W
HNF4a ligand binding domain with bound fatty acid
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003323 | biological_process | type B pancreatic cell development |
A | 0003700 | molecular_function | DNA-binding transcription factor activity |
A | 0050796 | biological_process | regulation of insulin secretion |
A | 0055088 | biological_process | lipid homeostasis |
A | 0070365 | biological_process | hepatocyte differentiation |
B | 0003323 | biological_process | type B pancreatic cell development |
B | 0003700 | molecular_function | DNA-binding transcription factor activity |
B | 0050796 | biological_process | regulation of insulin secretion |
B | 0055088 | biological_process | lipid homeostasis |
B | 0070365 | biological_process | hepatocyte differentiation |
C | 0003323 | biological_process | type B pancreatic cell development |
C | 0003700 | molecular_function | DNA-binding transcription factor activity |
C | 0050796 | biological_process | regulation of insulin secretion |
C | 0055088 | biological_process | lipid homeostasis |
C | 0070365 | biological_process | hepatocyte differentiation |
D | 0003323 | biological_process | type B pancreatic cell development |
D | 0003700 | molecular_function | DNA-binding transcription factor activity |
D | 0050796 | biological_process | regulation of insulin secretion |
D | 0055088 | biological_process | lipid homeostasis |
D | 0070365 | biological_process | hepatocyte differentiation |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE DAO A 700 |
Chain | Residue |
A | SER181 |
A | GLN185 |
A | ARG226 |
A | LEU236 |
A | GLY237 |
A | MET252 |
site_id | AC2 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE DAO B 701 |
Chain | Residue |
B | GLN185 |
B | ARG226 |
B | LEU236 |
B | GLY237 |
B | LEU249 |
B | MET252 |
B | HOH30 |
B | SER181 |
B | MET182 |
site_id | AC3 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE DAO C 702 |
Chain | Residue |
C | HOH31 |
C | VAL178 |
C | SER181 |
C | GLN185 |
C | ALA223 |
C | ARG226 |
C | LEU236 |
C | GLY237 |
C | MET252 |
C | ILE259 |
C | ILE346 |
site_id | AC4 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE DAO D 703 |
Chain | Residue |
D | SER181 |
D | GLN185 |
D | ARG226 |
D | LEU236 |
D | GLY237 |
D | MET252 |
D | SER256 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 8 |
Details | MOD_RES: Phosphoserine; by PKA => ECO:0000305|PubMed:9234678 |
Chain | Residue | Details |
A | SER142 | |
A | ILE143 | |
B | SER142 | |
B | ILE143 | |
C | SER142 | |
C | ILE143 | |
D | SER142 | |
D | ILE143 |
site_id | SWS_FT_FI2 |
Number of Residues | 4 |
Details | MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P41235 |
Chain | Residue | Details |
A | ASN144 | |
B | ASN144 | |
C | ASN144 | |
D | ASN144 |
site_id | SWS_FT_FI3 |
Number of Residues | 4 |
Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P41235 |
Chain | Residue | Details |
A | ASP166 | |
B | ASP166 | |
C | ASP166 | |
D | ASP166 |
site_id | SWS_FT_FI4 |
Number of Residues | 4 |
Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P41235 |
Chain | Residue | Details |
A | ILE167 | |
B | ILE167 | |
C | ILE167 | |
D | ILE167 |
site_id | SWS_FT_FI5 |
Number of Residues | 4 |
Details | MOD_RES: Phosphoserine; by AMPK => ECO:0000250|UniProtKB:P41235 |
Chain | Residue | Details |
A | TYR313 | |
B | TYR313 | |
C | TYR313 | |
D | TYR313 |
site_id | SWS_FT_FI6 |
Number of Residues | 12 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P41235 |
Chain | Residue | Details |
A | LEU234 | |
D | LEU234 | |
D | GLN307 | |
A | GLN307 | |
B | LEU234 | |
B | GLN307 | |
C | LEU234 | |
C | GLN307 |