1M7R

Crystal Structure of Myotubularin-related Protein-2 (MTMR2) Complexed with Phosphate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002091	biological_process	negative regulation of receptor internalization
A	0004438	molecular_function	phosphatidylinositol-3-phosphate phosphatase activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005768	cellular_component	endosome
A	0005774	cellular_component	vacuolar membrane
A	0005829	cellular_component	cytosol
A	0006629	biological_process	lipid metabolic process
A	0006661	biological_process	phosphatidylinositol biosynthetic process
A	0008021	cellular_component	synaptic vesicle
A	0010008	cellular_component	endosome membrane
A	0014069	cellular_component	postsynaptic density
A	0016020	cellular_component	membrane
A	0016787	molecular_function	hydrolase activity
A	0030424	cellular_component	axon
A	0030425	cellular_component	dendrite
A	0031642	biological_process	negative regulation of myelination
A	0031901	cellular_component	early endosome membrane
A	0032288	biological_process	myelin assembly
A	0042552	biological_process	myelination
A	0042802	molecular_function	identical protein binding
A	0042995	cellular_component	cell projection
A	0043197	cellular_component	dendritic spine
A	0045806	biological_process	negative regulation of endocytosis
A	0046488	biological_process	phosphatidylinositol metabolic process
A	0046856	biological_process	phosphatidylinositol dephosphorylation
A	0048471	cellular_component	perinuclear region of cytoplasm
A	0048666	biological_process	neuron development
A	0052629	molecular_function	phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity
A	0052866	molecular_function	phosphatidylinositol phosphate phosphatase activity
A	0060304	biological_process	regulation of phosphatidylinositol dephosphorylation
A	0070062	cellular_component	extracellular exosome
A	0090394	biological_process	negative regulation of excitatory postsynaptic potential
A	0097060	cellular_component	synaptic membrane
A	0097062	biological_process	dendritic spine maintenance
A	2000643	biological_process	positive regulation of early endosome to late endosome transport
A	2000645	biological_process	negative regulation of receptor catabolic process
B	0002091	biological_process	negative regulation of receptor internalization
B	0004438	molecular_function	phosphatidylinositol-3-phosphate phosphatase activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005768	cellular_component	endosome
B	0005774	cellular_component	vacuolar membrane
B	0005829	cellular_component	cytosol
B	0006629	biological_process	lipid metabolic process
B	0006661	biological_process	phosphatidylinositol biosynthetic process
B	0008021	cellular_component	synaptic vesicle
B	0010008	cellular_component	endosome membrane
B	0014069	cellular_component	postsynaptic density
B	0016020	cellular_component	membrane
B	0016787	molecular_function	hydrolase activity
B	0030424	cellular_component	axon
B	0030425	cellular_component	dendrite
B	0031642	biological_process	negative regulation of myelination
B	0031901	cellular_component	early endosome membrane
B	0032288	biological_process	myelin assembly
B	0042552	biological_process	myelination
B	0042802	molecular_function	identical protein binding
B	0042995	cellular_component	cell projection
B	0043197	cellular_component	dendritic spine
B	0045806	biological_process	negative regulation of endocytosis
B	0046488	biological_process	phosphatidylinositol metabolic process
B	0046856	biological_process	phosphatidylinositol dephosphorylation
B	0048471	cellular_component	perinuclear region of cytoplasm
B	0048666	biological_process	neuron development
B	0052629	molecular_function	phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity
B	0052866	molecular_function	phosphatidylinositol phosphate phosphatase activity
B	0060304	biological_process	regulation of phosphatidylinositol dephosphorylation
B	0070062	cellular_component	extracellular exosome
B	0090394	biological_process	negative regulation of excitatory postsynaptic potential
B	0097060	cellular_component	synaptic membrane
B	0097062	biological_process	dendritic spine maintenance
B	2000643	biological_process	positive regulation of early endosome to late endosome transport
B	2000645	biological_process	negative regulation of receptor catabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PO4 A 655

Chain	Residue
A	ARG459
A	LEU462
A	ARG463
A	ASP475
A	HOH1082

---

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PO4 A 656

Chain	Residue
A	TRP421
A	ASP422
A	ARG423
A	SER417
A	SER418
A	ASP419
A	GLY420

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PO4 B 655

Chain	Residue
B	TRP421
B	LEU462
B	ARG463
B	ASP475
B	HOH1038

---

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PO4 B 656

Chain	Residue
B	SER417
B	SER418
B	ASP419
B	GLY420
B	TRP421
B	ASP422
B	ARG423

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	750
Details	Domain: {"description":"Myotubularin phosphatase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00669","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Active site: {"description":"Phosphocysteine intermediate","evidences":[{"source":"PubMed","id":"14690594","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16410353","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	20
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16410353","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"1ZSQ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16410353","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"1ZVR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---