1M7E
Crystal structure of the phosphotyrosine binding domain(PTB) of mouse Disabled 2(Dab2):implications for Reeling signaling
Functional Information from PROSITE/UniProt
| site_id | PS00320 |
| Number of Residues | 8 |
| Details | APP_INTRA Amyloid precursor protein (APP) intracellular domain signature. GYENPTYK |
| Chain | Residue | Details |
| D | GLY502-LYS509 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"21183079","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 15 |
| Details | Motif: {"description":"YENPXY motif; contains endocytosis signal","evidences":[{"source":"UniProtKB","id":"P05067","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | Modified residue: {"description":"Phosphotyrosine; by ABL1","evidences":[{"source":"UniProtKB","id":"P12023","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"22847417","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
