Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1M6V

Crystal Structure of the G359F (small subunit) Point Mutant of Carbamoyl Phosphate Synthetase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004087	molecular_function	carbamoyl-phosphate synthase (ammonia) activity
A	0004088	molecular_function	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005951	cellular_component	carbamoyl-phosphate synthase complex
A	0006221	biological_process	pyrimidine nucleotide biosynthetic process
A	0006526	biological_process	L-arginine biosynthetic process
A	0006541	biological_process	glutamine metabolic process
A	0008652	biological_process	amino acid biosynthetic process
A	0016597	molecular_function	amino acid binding
A	0016874	molecular_function	ligase activity
A	0016879	molecular_function	ligase activity, forming carbon-nitrogen bonds
A	0019856	biological_process	pyrimidine nucleobase biosynthetic process
A	0044205	biological_process	'de novo' UMP biosynthetic process
A	0046872	molecular_function	metal ion binding
B	0000166	molecular_function	nucleotide binding
B	0004088	molecular_function	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
B	0004359	molecular_function	glutaminase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005951	cellular_component	carbamoyl-phosphate synthase complex
B	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
B	0006221	biological_process	pyrimidine nucleotide biosynthetic process
B	0006526	biological_process	L-arginine biosynthetic process
B	0006541	biological_process	glutamine metabolic process
B	0008652	biological_process	amino acid biosynthetic process
B	0016874	molecular_function	ligase activity
B	0019856	biological_process	pyrimidine nucleobase biosynthetic process
B	0044205	biological_process	'de novo' UMP biosynthetic process
B	0046982	molecular_function	protein heterodimerization activity
C	0000166	molecular_function	nucleotide binding
C	0004087	molecular_function	carbamoyl-phosphate synthase (ammonia) activity
C	0004088	molecular_function	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005951	cellular_component	carbamoyl-phosphate synthase complex
C	0006221	biological_process	pyrimidine nucleotide biosynthetic process
C	0006526	biological_process	L-arginine biosynthetic process
C	0006541	biological_process	glutamine metabolic process
C	0008652	biological_process	amino acid biosynthetic process
C	0016597	molecular_function	amino acid binding
C	0016874	molecular_function	ligase activity
C	0016879	molecular_function	ligase activity, forming carbon-nitrogen bonds
C	0019856	biological_process	pyrimidine nucleobase biosynthetic process
C	0044205	biological_process	'de novo' UMP biosynthetic process
C	0046872	molecular_function	metal ion binding
D	0000166	molecular_function	nucleotide binding
D	0004088	molecular_function	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
D	0004359	molecular_function	glutaminase activity
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005951	cellular_component	carbamoyl-phosphate synthase complex
D	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
D	0006221	biological_process	pyrimidine nucleotide biosynthetic process
D	0006526	biological_process	L-arginine biosynthetic process
D	0006541	biological_process	glutamine metabolic process
D	0008652	biological_process	amino acid biosynthetic process
D	0016874	molecular_function	ligase activity
D	0019856	biological_process	pyrimidine nucleobase biosynthetic process
D	0044205	biological_process	'de novo' UMP biosynthetic process
D	0046982	molecular_function	protein heterodimerization activity
E	0000166	molecular_function	nucleotide binding
E	0004087	molecular_function	carbamoyl-phosphate synthase (ammonia) activity
E	0004088	molecular_function	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0005951	cellular_component	carbamoyl-phosphate synthase complex
E	0006221	biological_process	pyrimidine nucleotide biosynthetic process
E	0006526	biological_process	L-arginine biosynthetic process
E	0006541	biological_process	glutamine metabolic process
E	0008652	biological_process	amino acid biosynthetic process
E	0016597	molecular_function	amino acid binding
E	0016874	molecular_function	ligase activity
E	0016879	molecular_function	ligase activity, forming carbon-nitrogen bonds
E	0019856	biological_process	pyrimidine nucleobase biosynthetic process
E	0044205	biological_process	'de novo' UMP biosynthetic process
E	0046872	molecular_function	metal ion binding
F	0000166	molecular_function	nucleotide binding
F	0004088	molecular_function	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
F	0004359	molecular_function	glutaminase activity
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0005951	cellular_component	carbamoyl-phosphate synthase complex
F	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
F	0006221	biological_process	pyrimidine nucleotide biosynthetic process
F	0006526	biological_process	L-arginine biosynthetic process
F	0006541	biological_process	glutamine metabolic process
F	0008652	biological_process	amino acid biosynthetic process
F	0016874	molecular_function	ligase activity
F	0019856	biological_process	pyrimidine nucleobase biosynthetic process
F	0044205	biological_process	'de novo' UMP biosynthetic process
F	0046982	molecular_function	protein heterodimerization activity
G	0000166	molecular_function	nucleotide binding
G	0004087	molecular_function	carbamoyl-phosphate synthase (ammonia) activity
G	0004088	molecular_function	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
G	0005515	molecular_function	protein binding
G	0005524	molecular_function	ATP binding
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0005951	cellular_component	carbamoyl-phosphate synthase complex
G	0006221	biological_process	pyrimidine nucleotide biosynthetic process
G	0006526	biological_process	L-arginine biosynthetic process
G	0006541	biological_process	glutamine metabolic process
G	0008652	biological_process	amino acid biosynthetic process
G	0016597	molecular_function	amino acid binding
G	0016874	molecular_function	ligase activity
G	0016879	molecular_function	ligase activity, forming carbon-nitrogen bonds
G	0019856	biological_process	pyrimidine nucleobase biosynthetic process
G	0044205	biological_process	'de novo' UMP biosynthetic process
G	0046872	molecular_function	metal ion binding
H	0000166	molecular_function	nucleotide binding
H	0004088	molecular_function	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H	0004359	molecular_function	glutaminase activity
H	0005515	molecular_function	protein binding
H	0005524	molecular_function	ATP binding
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0005951	cellular_component	carbamoyl-phosphate synthase complex
H	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
H	0006221	biological_process	pyrimidine nucleotide biosynthetic process
H	0006526	biological_process	L-arginine biosynthetic process
H	0006541	biological_process	glutamine metabolic process
H	0008652	biological_process	amino acid biosynthetic process
H	0016874	molecular_function	ligase activity
H	0019856	biological_process	pyrimidine nucleobase biosynthetic process
H	0044205	biological_process	'de novo' UMP biosynthetic process
H	0046982	molecular_function	protein heterodimerization activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN A 4002

Chain	Residue
A	GLU299
A	ASN301
A	ADP4001
A	MN4003
A	PO44006
A	HOH4111

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN A 4003

Chain	Residue
A	MN4002
A	PO44006
A	HOH4537
A	GLN285
A	GLU299
A	ADP4001

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K A 4004

Chain	Residue
A	GLU215
A	ASN236
A	ASP238
A	ALA239
A	ILE242
A	SER247

site_id	AC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE K A 4005

Chain	Residue
A	ALA126
A	GLU127
A	GLU299
A	MET300
A	ASN301
A	HOH4111
A	HOH4112
A	HOH4113

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN A 4008

Chain	Residue
A	GLN829
A	GLU841
A	ADP4007
A	HOH4590
A	HOH4638

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE K A 4009

Chain	Residue
A	GLU841
A	ASN843
A	ADP4007
A	HOH4434

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K A 4010

Chain	Residue
A	GLU761
A	HIS781
A	GLU783
A	GLN784
A	VAL787
A	SER792

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K A 4013

Chain	Residue
A	ASP84
A	GLY112
A	THR114
A	HOH4021
A	HOH4679
A	HOH4680

site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE K B 4014

Chain	Residue
A	HOH4363
B	HIS16
B	ASP112
B	HOH4042
B	HOH4089

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL A 4015

Chain	Residue
A	THR173
A	MET174
A	HOH4048
A	HOH4093

site_id	BC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL A 4016

Chain	Residue
A	ASN289
A	ASN292
A	ARG294

site_id	BC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CL A 4017

Chain	Residue
A	ALA370
A	ASN371
A	PHE900
A	PRO901
A	GLY902
A	HOH4167

site_id	BC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL A 4018

Chain	Residue
A	LYS475
A	ASN485

site_id	BC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL B 4019

Chain	Residue
A	HOH4363
B	ILE113
B	ASP114
B	HOH4041

site_id	BC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL A 4020

Chain	Residue
A	PHE578
A	ALA847
A	ARG848

site_id	BC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN C 4022

Chain	Residue
C	GLU299
C	ASN301
C	ADP4021
C	MN4023
C	PO44026
C	HOH4133

site_id	BC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN C 4023

Chain	Residue
C	GLN285
C	GLU299
C	ADP4021
C	MN4022
C	PO44026
C	HOH4628

site_id	BC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K C 4024

Chain	Residue
C	GLU215
C	ASN236
C	ASP238
C	ALA239
C	ILE242
C	SER247

site_id	CC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE K C 4025

Chain	Residue
C	ALA126
C	GLU127
C	GLU299
C	MET300
C	ASN301
C	HOH4133
C	HOH4135

site_id	CC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN C 4028

Chain	Residue
C	GLN829
C	GLU841
C	ADP4027
C	HOH4630
C	HOH4631

site_id	CC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE K C 4029

Chain	Residue
C	GLU841
C	ADP4027
C	HOH4440

site_id	CC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K C 4030

Chain	Residue
C	GLU761
C	HIS781
C	GLU783
C	GLN784
C	VAL787
C	SER792

site_id	CC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE K C 4033

Chain	Residue
C	ASP84
C	GLY112
C	THR114

site_id	CC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE K C 4034

Chain	Residue
C	THR143
C	ALA144
C	HOH4143
C	HOH4145

site_id	CC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE K D 4035

Chain	Residue
C	HOH4372
D	HIS16
D	ASP112
D	HOH1022

site_id	CC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL C 4036

Chain	Residue
C	MET174
C	NET4032
C	HOH4070
C	HOH4115

site_id	CC9
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL C 4037

Chain	Residue
C	TRP71

site_id	DC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL C 4038

Chain	Residue
C	ASN289
C	ASN292
C	ARG294

site_id	DC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL C 4039

Chain	Residue
C	ALA370
C	ASN371
C	PHE900
C	PRO901
C	GLY902

site_id	DC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL C 4040

Chain	Residue
C	LYS475
C	ASN485
C	HOH4567

site_id	DC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL C 4041

Chain	Residue
C	GLU549
D	ILE113
D	ASP114
D	HOH1021

site_id	DC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL C 4042

Chain	Residue
C	ALA847
C	ARG848

site_id	DC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL D 4043

Chain	Residue
D	SER169
D	TRP170
D	THR171

site_id	DC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN E 4045

Chain	Residue
E	GLU299
E	ASN301
E	HOH1271
E	ADP4044
E	MN4046
E	PO44049

site_id	DC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MN E 4046

Chain	Residue
E	HIS243
E	GLN285
E	GLU299
E	HOH2516
E	ADP4044
E	MN4045
E	PO44049

site_id	DC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K E 4047

Chain	Residue
E	GLU215
E	ASN236
E	ASP238
E	ALA239
E	ILE242
E	SER247

site_id	EC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE K E 4048

Chain	Residue
E	ALA126
E	GLU127
E	GLU299
E	MET300
E	ASN301
E	HOH1271
E	HOH1273

site_id	EC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN E 4051

Chain	Residue
E	GLN829
E	GLU841
E	HOH2518
E	HOH2519
E	ADP4050

site_id	EC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE K E 4052

Chain	Residue
E	GLU841
E	ASN843
E	HOH1603
E	HOH1604
E	ADP4050

site_id	EC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K E 4053

Chain	Residue
E	GLU761
E	HIS781
E	GLU783
E	GLN784
E	VAL787
E	SER792

site_id	EC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE K E 4056

Chain	Residue
E	ASP84
E	GLY112
E	THR114
E	HOH1176
E	HOH2520

site_id	EC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE K E 4057

Chain	Residue
E	THR143
E	ALA144
E	HOH1280
E	HOH1282

site_id	EC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE K F 4058

Chain	Residue
E	HOH1526
E	HOH1558
E	HOH2780
F	HIS16
F	ASP112

site_id	EC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL E 4059

Chain	Residue
E	GLN93
E	THR173
E	MET174
E	HOH1203
E	HOH1252

site_id	EC9
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL E 4060

Chain	Residue
E	TRP71

site_id	FC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL E 4061

Chain	Residue
E	ASN289
E	ASN292
E	ARG294

site_id	FC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL E 4062

Chain	Residue
E	ALA370
E	ASN371
E	PHE900
E	PRO901
E	GLY902

site_id	FC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL E 4063

Chain	Residue
E	LYS475
E	ASN485
E	HOH2644

site_id	FC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL F 4064

Chain	Residue
F	PHE15
F	ASP114

site_id	FC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL E 4065

Chain	Residue
E	ARG845
E	ALA847
E	ARG848

site_id	FC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN G 4067

Chain	Residue
G	GLU299
G	ASN301
G	ADP4066
G	MN4068
G	PO44071
G	HOH4181

site_id	FC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN G 4068

Chain	Residue
G	GLN285
G	GLU299
G	ADP4066
G	MN4067
G	PO44071
G	HOH4540

site_id	FC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K G 4069

Chain	Residue
G	GLU215
G	ASN236
G	ASP238
G	ALA239
G	ILE242
G	SER247

site_id	FC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K G 4070

Chain	Residue
G	ALA126
G	GLU127
G	GLU299
G	MET300
G	ASN301
G	HOH4183

site_id	GC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN G 4073

Chain	Residue
G	GLN829
G	GLU841
G	ADP4072
G	HOH4541
G	HOH4542

site_id	GC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE K G 4074

Chain	Residue
G	GLU841
G	ASN843
G	ADP4072
G	HOH4464

site_id	GC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K G 4075

Chain	Residue
G	GLU761
G	HIS781
G	GLU783
G	GLN784
G	VAL787
G	SER792

site_id	GC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE K G 4078

Chain	Residue
G	ASP84
G	GLY112
G	THR114

site_id	GC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE K G 4079

Chain	Residue
G	THR143
G	ALA144
G	HOH4190
G	HOH4192

site_id	GC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL G 4080

Chain	Residue
G	GLN93
G	THR173
G	MET174
G	HOH4161

site_id	GC7
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL G 4081

Chain	Residue
G	TRP71

site_id	GC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL G 4082

Chain	Residue
G	ASN289
G	ASN292
G	ARG294

site_id	GC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL G 4083

Chain	Residue
G	ALA370
G	ASN371
G	PHE900
G	PRO901
G	GLY902

site_id	HC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL G 4084

Chain	Residue
G	LYS475
G	ASN485

site_id	HC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL H 4085

Chain	Residue
H	PHE15
H	ASP114
H	HOH2082

site_id	HC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL G 4086

Chain	Residue
G	ARG845
G	ALA847
G	ARG848

site_id	HC4
Number of Residues	14
Details	BINDING SITE FOR RESIDUE PO4 A 4006

Chain	Residue
A	MET174
A	GLY175
A	HIS243
A	GLN285
A	GLU299
A	ASN301
A	ARG303
A	ARG306
A	ADP4001
A	MN4002
A	MN4003
A	HOH4055
A	HOH4214
A	HOH4215

site_id	HC5
Number of Residues	14
Details	BINDING SITE FOR RESIDUE PO4 C 4026

Chain	Residue
C	MET174
C	GLY175
C	HIS243
C	GLN285
C	GLU299
C	ASN301
C	ARG303
C	ARG306
C	ADP4021
C	MN4022
C	MN4023
C	HOH4077
C	HOH4231
C	HOH4232

site_id	HC6
Number of Residues	14
Details	BINDING SITE FOR RESIDUE PO4 E 4049

Chain	Residue
E	MET174
E	GLY175
E	HIS243
E	GLN285
E	GLU299
E	ASN301
E	ARG303
E	ARG306
E	HOH1210
E	HOH1371
E	HOH1372
E	ADP4044
E	MN4045
E	MN4046

site_id	HC7
Number of Residues	15
Details	BINDING SITE FOR RESIDUE PO4 G 4071

Chain	Residue
G	MET174
G	GLY175
G	HIS243
G	GLN285
G	GLU299
G	ASN301
G	ARG303
G	ARG306
G	ADP4066
G	MN4067
G	MN4068
G	HOH4123
G	HOH4275
G	HOH4276
G	HOH4540

site_id	HC8
Number of Residues	26
Details	BINDING SITE FOR RESIDUE ADP A 4001

Chain	Residue
A	ARG129
A	ILE167
A	ARG169
A	MET174
A	GLY175
A	GLY176
A	ASP207
A	GLU208
A	LEU210
A	ILE211
A	GLU215
A	MET240
A	GLY241
A	ILE242
A	HIS243
A	THR244
A	GLN285
A	GLU299
A	THR376
A	MN4002
A	MN4003
A	PO44006
A	HOH4111
A	HOH4144
A	HOH4157
A	HOH4537

site_id	HC9
Number of Residues	20
Details	BINDING SITE FOR RESIDUE ADP A 4007

Chain	Residue
A	ARG715
A	MET725
A	HIS754
A	PHE755
A	LEU756
A	GLU761
A	ALA785
A	GLY786
A	VAL787
A	HIS788
A	SER789
A	GLN829
A	GLU841
A	PRO909
A	MN4008
A	K4009
A	HOH4432
A	HOH4434
A	HOH4590
A	HOH4638

site_id	IC1
Number of Residues	13
Details	BINDING SITE FOR RESIDUE ORN A 4011

Chain	Residue
A	GLU783
A	ASP791
A	ALA793
A	GLU892
A	VAL893
A	LEU907
A	TYR1040
A	ASP1041
A	THR1042
A	HOH4448
A	HOH4468
A	HOH4473
A	HOH4639

site_id	IC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE NET A 4012

Chain	Residue
A	GLN22
A	THR94
A	ASN936

site_id	IC3
Number of Residues	28
Details	BINDING SITE FOR RESIDUE ADP C 4021

Chain	Residue
C	ARG129
C	ILE167
C	ARG169
C	THR173
C	MET174
C	GLY175
C	GLY176
C	ASP207
C	GLU208
C	SER209
C	LEU210
C	ILE211
C	GLU215
C	MET240
C	GLY241
C	ILE242
C	HIS243
C	THR244
C	GLN285
C	ILE298
C	GLU299
C	THR376
C	MN4022
C	MN4023
C	PO44026
C	HOH4133
C	HOH4175
C	HOH4628

site_id	IC4
Number of Residues	20
Details	BINDING SITE FOR RESIDUE ADP C 4027

Chain	Residue
C	PRO690
C	ARG715
C	MET725
C	HIS754
C	PHE755
C	LEU756
C	GLU761
C	ALA785
C	GLY786
C	VAL787
C	HIS788
C	SER789
C	GLN829
C	GLU841
C	MN4028
C	K4029
C	HOH4439
C	HOH4440
C	HOH4630
C	HOH4631

site_id	IC5
Number of Residues	11
Details	BINDING SITE FOR RESIDUE ORN C 4031

Chain	Residue
C	GLU783
C	ASP791
C	ALA793
C	GLU892
C	VAL893
C	LEU907
C	TYR1040
C	ASP1041
C	THR1042
C	HOH4452
C	HOH4476

site_id	IC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE NET C 4032

Chain	Residue
C	THR94
C	CL4036

site_id	IC7
Number of Residues	25
Details	BINDING SITE FOR RESIDUE ADP E 4044

Chain	Residue
E	ARG129
E	ILE167
E	ARG169
E	MET174
E	GLY175
E	GLY176
E	GLU208
E	LEU210
E	ILE211
E	GLU215
E	MET240
E	GLY241
E	ILE242
E	HIS243
E	THR244
E	GLN285
E	GLU299
E	THR376
E	HOH1271
E	HOH1303
E	HOH1315
E	HOH2516
E	MN4045
E	MN4046
E	PO44049

site_id	IC8
Number of Residues	21
Details	BINDING SITE FOR RESIDUE ADP E 4050

Chain	Residue
E	ARG715
E	MET725
E	HIS754
E	PHE755
E	LEU756
E	GLU761
E	ALA785
E	GLY786
E	VAL787
E	HIS788
E	SER789
E	GLN829
E	GLU841
E	HOH1577
E	HOH1603
E	HOH1604
E	HOH2517
E	HOH2518
E	HOH2519
E	MN4051
E	K4052

site_id	IC9
Number of Residues	10
Details	BINDING SITE FOR RESIDUE ORN E 4054

Chain	Residue
E	GLU783
E	ASP791
E	GLU892
E	LEU907
E	TYR1040
E	ASP1041
E	THR1042
E	HOH1617
E	HOH1618
E	HOH1644

site_id	JC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE NET E 4055

Chain	Residue
E	THR94
E	ASN936
E	HOH1188

site_id	JC2
Number of Residues	28
Details	BINDING SITE FOR RESIDUE ADP G 4066

Chain	Residue
G	ARG129
G	ILE167
G	ARG169
G	THR173
G	MET174
G	GLY175
G	GLY176
G	ASP207
G	GLU208
G	LEU210
G	ILE211
G	GLU215
G	MET240
G	GLY241
G	ILE242
G	HIS243
G	THR244
G	GLN285
G	ILE298
G	GLU299
G	THR376
G	MN4067
G	MN4068
G	PO44071
G	HOH4181
G	HOH4211
G	HOH4222
G	HOH4540

site_id	JC3
Number of Residues	19
Details	BINDING SITE FOR RESIDUE ADP G 4072

Chain	Residue
G	ARG715
G	HIS754
G	PHE755
G	LEU756
G	GLU761
G	ALA785
G	GLY786
G	VAL787
G	HIS788
G	SER789
G	GLN829
G	GLU841
G	MN4073
G	K4074
G	HOH4444
G	HOH4463
G	HOH4464
G	HOH4541
G	HOH4542

site_id	JC4
Number of Residues	10
Details	BINDING SITE FOR RESIDUE ORN G 4076

Chain	Residue
G	GLU783
G	ASP791
G	GLU892
G	LEU907
G	TYR1040
G	ASP1041
G	THR1042
G	HOH4476
G	HOH4501
G	HOH4511

site_id	JC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE NET G 4077

Chain	Residue
G	GLN22
G	THR94
G	ASN97

Functional Information from PROSITE/UniProt

site_id	PS00866
Number of Residues	15
Details	CPSASE_1 Carbamoyl-phosphate synthase subdomain signature 1. FPCIIRPSftmGGsG

Chain	Residue	Details
A	PHE164-GLY178
A	TYR710-ALA724

site_id	PS00867
Number of Residues	8
Details	CPSASE_2 Carbamoyl-phosphate synthase subdomain signature 2. VIEMNPRV

Chain	Residue	Details
A	VAL297-VAL304
A	LEU839-ALA846

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	780
Details	Domain: {"description":"ATP-grasp 1","evidences":[{"source":"HAMAP-Rule","id":"MF_01210","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	544
Details	Domain: {"description":"MGS-like","evidences":[{"source":"HAMAP-Rule","id":"MF_01210","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	1604
Details	Region: {"description":"Carboxyphosphate synthetic domain","evidences":[{"source":"HAMAP-Rule","id":"MF_01210","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	596
Details	Region: {"description":"Oligomerization domain","evidences":[{"source":"HAMAP-Rule","id":"MF_01210","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	544
Details	Region: {"description":"Allosteric domain","evidences":[{"source":"HAMAP-Rule","id":"MF_01210","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	72
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01210","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"10029528","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1A9X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1C30","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1C3O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1CE8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1CS0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1JDB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1KEE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1M6V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T36","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01210","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"10428826","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1CE8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01210","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"10029528","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10089390","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10428826","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10587438","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9636022","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1CE8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01210","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"10428826","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9636022","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1CE8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01210","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"10029528","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10089390","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10428826","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9636022","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1CE8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01210","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"10029528","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10089390","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	4
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"HAMAP-Rule","id":"MF_01209","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	8
Details	Active site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01209","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	32
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01209","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"10587438","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1C3O","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	Annotated By Reference To The Literature 1bxr

Chain	Residue	Details
F	HIS353
F	CYS269
F	GLU355

site_id	CSA2
Number of Residues	3
Details	Annotated By Reference To The Literature 1bxr

Chain	Residue	Details
H	HIS353
H	CYS269
H	GLU355

site_id	CSA3
Number of Residues	3
Details	Annotated By Reference To The Literature 1bxr

Chain	Residue	Details
B	HIS353
B	CYS269
B	GLU355

site_id	CSA4
Number of Residues	3
Details	Annotated By Reference To The Literature 1bxr

Chain	Residue	Details
D	HIS353
D	CYS269
D	GLU355

site_id	CSA5
Number of Residues	2
Details	Annotated By Reference To The Literature 1bxr

Chain	Residue	Details
B	HIS353
B	CYS269

site_id	CSA6
Number of Residues	2
Details	Annotated By Reference To The Literature 1bxr

Chain	Residue	Details
D	HIS353
D	CYS269

site_id	CSA7
Number of Residues	2
Details	Annotated By Reference To The Literature 1bxr

Chain	Residue	Details
F	HIS353
F	CYS269

site_id	CSA8
Number of Residues	2
Details	Annotated By Reference To The Literature 1bxr

Chain	Residue	Details
H	HIS353
H	CYS269

site_id	MCSA1
Number of Residues	3
Details	M-CSA 435

Chain	Residue	Details
B	CYS269	covalent catalysis, proton shuttle (general acid/base)
A	ARG303	electrostatic stabiliser
A	ARG715	electrostatic stabiliser
A	GLU761	steric role
A	GLN829	metal ligand
A	GLU841	metal ligand
A	ASN843	metal ligand
A	ARG848	electrostatic stabiliser
B	HIS353	proton shuttle (general acid/base)
B	GLU355	steric role
A	GLU215	steric role
A	HIS243	proton shuttle (general acid/base)
A	ASN283	electrostatic stabiliser
A	GLN285	metal ligand
A	GLU299	metal ligand
A	ASN301	metal ligand

site_id	MCSA2
Number of Residues	3
Details	M-CSA 435

Chain	Residue	Details
D	CYS269	covalent catalysis, proton shuttle (general acid/base)
C	ARG303	electrostatic stabiliser
C	ARG715	electrostatic stabiliser
C	GLU761	steric role
C	GLN829	metal ligand
C	GLU841	metal ligand
C	ASN843	metal ligand
C	ARG848	electrostatic stabiliser
D	HIS353	proton shuttle (general acid/base)
D	GLU355	steric role
C	GLU215	steric role
C	HIS243	proton shuttle (general acid/base)
C	ASN283	electrostatic stabiliser
C	GLN285	metal ligand
C	GLU299	metal ligand
C	ASN301	metal ligand

site_id	MCSA3
Number of Residues	3
Details	M-CSA 435

Chain	Residue	Details
F	CYS269	covalent catalysis, proton shuttle (general acid/base)
E	ARG303	electrostatic stabiliser
E	ARG715	electrostatic stabiliser
E	GLU761	steric role
E	GLN829	metal ligand
E	GLU841	metal ligand
E	ASN843	metal ligand
E	ARG848	electrostatic stabiliser
F	HIS353	proton shuttle (general acid/base)
F	GLU355	steric role
E	GLU215	steric role
E	HIS243	proton shuttle (general acid/base)
E	ASN283	electrostatic stabiliser
E	GLN285	metal ligand
E	GLU299	metal ligand
E	ASN301	metal ligand

site_id	MCSA4
Number of Residues	3
Details	M-CSA 435

Chain	Residue	Details
H	CYS269	covalent catalysis, proton shuttle (general acid/base)
G	ARG303	electrostatic stabiliser
G	ARG715	electrostatic stabiliser
G	GLU761	steric role
G	GLN829	metal ligand
G	GLU841	metal ligand
G	ASN843	metal ligand
G	ARG848	electrostatic stabiliser
H	HIS353	proton shuttle (general acid/base)
H	GLU355	steric role
G	GLU215	steric role
G	HIS243	proton shuttle (general acid/base)
G	ASN283	electrostatic stabiliser
G	GLN285	metal ligand
G	GLU299	metal ligand
G	ASN301	metal ligand

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)