1M5F

X-RAY STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2J-Y702F) IN COMPLEX WITH ACPA AT 1.95 A RESOLUTION

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0015276	molecular_function	ligand-gated monoatomic ion channel activity
A	0016020	cellular_component	membrane
B	0015276	molecular_function	ligand-gated monoatomic ion channel activity
B	0016020	cellular_component	membrane
C	0015276	molecular_function	ligand-gated monoatomic ion channel activity
C	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACT B 1203

Chain	Residue
A	LYS45
B	LYS144
B	PHE170
B	ZN1209
B	HOH1216

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 1204

Chain	Residue
A	HIS23
A	HOH1420
C	ASP65
C	HOH1463

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 1205

Chain	Residue
A	GLU42
A	HIS46
B	GLU166
B	ZN1209

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 1206

Chain	Residue
B	HIS23
B	GLU30
C	HIS23
C	GLU24

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ZN B 1207

Chain	Residue
A	GLU166
B	GLU42
B	LYS45
B	HIS46
B	LEU241
B	HOH1529

---

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN C 1208

Chain	Residue
C	GLU42
C	LYS45
C	HIS46

---

site_id	AC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN B 1209

Chain	Residue
B	ACT1203
B	ZN1205
B	HOH1342

---

site_id	AC8
Number of Residues	14
Details	BINDING SITE FOR RESIDUE AM1 A 1200

Chain	Residue
A	TYR61
A	PRO89
A	LEU90
A	THR91
A	ARG96
A	GLY141
A	SER142
A	THR143
A	LEU192
A	GLU193
A	MET196
A	TYR220
A	HOH1230
A	HOH1254

---

site_id	AC9
Number of Residues	14
Details	BINDING SITE FOR RESIDUE AM1 B 1201

Chain	Residue
B	TYR61
B	PRO89
B	LEU90
B	THR91
B	ARG96
B	GLY141
B	SER142
B	THR143
B	LEU192
B	GLU193
B	MET196
B	TYR220
B	HOH1254
B	HOH1280

---

site_id	BC1
Number of Residues	14
Details	BINDING SITE FOR RESIDUE AM1 C 1202

Chain	Residue
C	TYR61
C	PRO89
C	LEU90
C	THR91
C	ARG96
C	GLY141
C	SER142
C	THR143
C	LEU192
C	GLU193
C	MET196
C	TYR220
C	HOH1245
C	HOH1255

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	18
Details	BINDING: BINDING => ECO:0000269|PubMed:11086992, ECO:0000269|PubMed:16483599, ECO:0007744|PDB:1FTJ, ECO:0007744|PDB:2CMO

Chain	Residue	Details
A	PRO89
B	SER142
B	THR143
B	GLU193
C	PRO89
C	THR91
C	ARG96
C	SER142
C	THR143
C	GLU193
A	THR91
A	ARG96
A	SER142
A	THR143
A	GLU193
B	PRO89
B	THR91
B	ARG96

---

site_id	SWS_FT_FI2
Number of Residues	9
Details	SITE: Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405

Chain	Residue	Details
A	ARG64
A	ARG148
A	LYS240
B	ARG64
B	ARG148
B	LYS240
C	ARG64
C	ARG148
C	LYS240

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	SITE: Crucial to convey clamshell closure to channel opening => ECO:0000269|PubMed:25103405

Chain	Residue	Details
A	ILE121
B	ILE121
C	ILE121

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	MOD_RES: Phosphoserine; by PKC => ECO:0000269|PubMed:8848293

Chain	Residue	Details
A	SER150
B	SER150
C	SER150

---

site_id	SWS_FT_FI5
Number of Residues	3
Details	MOD_RES: Phosphoserine; by PKG => ECO:0000269|PubMed:8848293

Chain	Residue	Details
A	SER184
B	SER184
C	SER184

---

site_id	SWS_FT_FI6
Number of Residues	3
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN3
B	ASN3
C	ASN3

---