1M4S
Biosynthetic thiolase, Cys89 acetylated, unliganded form
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003985 | molecular_function | acetyl-CoA C-acetyltransferase activity |
A | 0005737 | cellular_component | cytoplasm |
A | 0005829 | cellular_component | cytosol |
A | 0006635 | biological_process | fatty acid beta-oxidation |
A | 0016740 | molecular_function | transferase activity |
A | 0016746 | molecular_function | acyltransferase activity |
A | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
A | 0042619 | biological_process | poly-hydroxybutyrate biosynthetic process |
B | 0003985 | molecular_function | acetyl-CoA C-acetyltransferase activity |
B | 0005737 | cellular_component | cytoplasm |
B | 0005829 | cellular_component | cytosol |
B | 0006635 | biological_process | fatty acid beta-oxidation |
B | 0016740 | molecular_function | transferase activity |
B | 0016746 | molecular_function | acyltransferase activity |
B | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
B | 0042619 | biological_process | poly-hydroxybutyrate biosynthetic process |
C | 0003985 | molecular_function | acetyl-CoA C-acetyltransferase activity |
C | 0005737 | cellular_component | cytoplasm |
C | 0005829 | cellular_component | cytosol |
C | 0006635 | biological_process | fatty acid beta-oxidation |
C | 0016740 | molecular_function | transferase activity |
C | 0016746 | molecular_function | acyltransferase activity |
C | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
C | 0042619 | biological_process | poly-hydroxybutyrate biosynthetic process |
D | 0003985 | molecular_function | acetyl-CoA C-acetyltransferase activity |
D | 0005737 | cellular_component | cytoplasm |
D | 0005829 | cellular_component | cytosol |
D | 0006635 | biological_process | fatty acid beta-oxidation |
D | 0016740 | molecular_function | transferase activity |
D | 0016746 | molecular_function | acyltransferase activity |
D | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
D | 0042619 | biological_process | poly-hydroxybutyrate biosynthetic process |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 A 9720 |
Chain | Residue |
A | SER260 |
A | ALA262 |
A | GLU263 |
A | ARG266 |
site_id | AC2 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE SO4 A 9722 |
Chain | Residue |
A | LYS298 |
A | ARG302 |
A | HOH9939 |
site_id | AC3 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE GOL A 5393 |
Chain | Residue |
A | ALA318 |
A | PHE319 |
A | HIS348 |
A | HOH433 |
A | HOH498 |
A | HOH517 |
A | HOH524 |
A | HOH9781 |
A | HIS156 |
A | SER247 |
site_id | AC4 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE GOL A 5394 |
Chain | Residue |
A | ALA37 |
A | ARG41 |
A | ILE199 |
A | HOH407 |
A | HOH462 |
A | HOH9855 |
A | HOH9921 |
site_id | AC5 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 B 9719 |
Chain | Residue |
B | LYS298 |
B | ARG302 |
B | HOH515 |
B | HOH9863 |
site_id | AC6 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE SO4 B 9721 |
Chain | Residue |
B | SER260 |
B | ARG266 |
B | HOH9870 |
site_id | AC7 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE GOL B 6393 |
Chain | Residue |
B | LEU148 |
B | HIS156 |
B | SER247 |
B | GLY248 |
B | LEU249 |
B | HOH468 |
B | HOH9779 |
site_id | AC8 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE GOL B 6394 |
Chain | Residue |
B | ALA37 |
B | ARG41 |
B | ILE199 |
B | HOH442 |
B | HOH503 |
B | HOH9911 |
B | HOH9913 |
Functional Information from PROSITE/UniProt
site_id | PS00098 |
Number of Residues | 19 |
Details | THIOLASE_1 Thiolases acyl-enzyme intermediate signature. MNQlCGSGLrAValgmqqI |
Chain | Residue | Details |
A | MET85-ILE103 |
site_id | PS00099 |
Number of Residues | 14 |
Details | THIOLASE_3 Thiolases active site. GLATLCIGgGmGvA |
Chain | Residue | Details |
A | GLY373-ALA386 |
site_id | PS00737 |
Number of Residues | 17 |
Details | THIOLASE_2 Thiolases signature 2. NvnGGaIAiGHPiGaSG |
Chain | Residue | Details |
A | ASN338-GLY354 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 4 |
Details | ACT_SITE: Acyl-thioester intermediate |
Chain | Residue | Details |
A | SCY89 | |
B | SCY89 | |
C | SCY89 | |
D | SCY89 |
site_id | SWS_FT_FI2 |
Number of Residues | 8 |
Details | ACT_SITE: Proton acceptor |
Chain | Residue | Details |
A | HIS348 | |
A | CYS378 | |
B | HIS348 | |
B | CYS378 | |
C | HIS348 | |
C | CYS378 | |
D | HIS348 | |
D | CYS378 |