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1M47

Crystal Structure of Human Interleukin-2

Functional Information from GO Data
ChainGOidnamespacecontents
A0002250biological_processadaptive immune response
A0002366biological_processleukocyte activation involved in immune response
A0002376biological_processimmune system process
A0002639biological_processpositive regulation of immunoglobulin production
A0002903biological_processnegative regulation of B cell apoptotic process
A0005125molecular_functioncytokine activity
A0005134molecular_functioninterleukin-2 receptor binding
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005893cellular_componentinterleukin-2 receptor complex
A0006955biological_processimmune response
A0007155biological_processcell adhesion
A0007186biological_processG protein-coupled receptor signaling pathway
A0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
A0007204biological_processpositive regulation of cytosolic calcium ion concentration
A0007259biological_processcell surface receptor signaling pathway via JAK-STAT
A0007267biological_processcell-cell signaling
A0008083molecular_functiongrowth factor activity
A0008284biological_processpositive regulation of cell population proliferation
A0019209molecular_functionkinase activator activity
A0030101biological_processnatural killer cell activation
A0030217biological_processT cell differentiation
A0030246molecular_functioncarbohydrate binding
A0030307biological_processpositive regulation of cell growth
A0030890biological_processpositive regulation of B cell proliferation
A0031851molecular_functionkappa-type opioid receptor binding
A0032740biological_processpositive regulation of interleukin-17 production
A0034105biological_processpositive regulation of tissue remodeling
A0038110biological_processinterleukin-2-mediated signaling pathway
A0042102biological_processpositive regulation of T cell proliferation
A0042104biological_processpositive regulation of activated T cell proliferation
A0043066biological_processnegative regulation of apoptotic process
A0043208molecular_functionglycosphingolipid binding
A0045471biological_processresponse to ethanol
A0045582biological_processpositive regulation of T cell differentiation
A0045591biological_processpositive regulation of regulatory T cell differentiation
A0045621biological_processpositive regulation of lymphocyte differentiation
A0050729biological_processpositive regulation of inflammatory response
A0060999biological_processpositive regulation of dendritic spine development
A0070665biological_processpositive regulation of leukocyte proliferation
A0097696biological_processcell surface receptor signaling pathway via STAT
A1900100biological_processpositive regulation of plasma cell differentiation
A1901327biological_processresponse to tacrolimus
A1902107biological_processpositive regulation of leukocyte differentiation
A2000320biological_processnegative regulation of T-helper 17 cell differentiation
Functional Information from PDB Data
site_idAC1
Number of Residues5
DetailsBINDING SITE FOR RESIDUE SO4 A 134
ChainResidue
ALYS49
ALYS54
AHIS55
APHE103
ATHR133

site_idAC2
Number of Residues3
DetailsBINDING SITE FOR RESIDUE SO4 A 135
ChainResidue
ATYR31
ALYS32
ALYS35

Functional Information from PROSITE/UniProt
site_idPS00424
Number of Residues13
DetailsINTERLEUKIN_2 Interleukin-2 signature. TELkhLqCLeeEL
ChainResidueDetails
ATHR51-LEU63

245663

PDB entries from 2025-12-03

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