Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1M3U

Crystal Structure of Ketopantoate Hydroxymethyltransferase complexed the Product Ketopantoate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0003864	molecular_function	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0015940	biological_process	pantothenate biosynthetic process
A	0016020	cellular_component	membrane
A	0042802	molecular_function	identical protein binding
B	0000287	molecular_function	magnesium ion binding
B	0003864	molecular_function	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0015940	biological_process	pantothenate biosynthetic process
B	0016020	cellular_component	membrane
B	0042802	molecular_function	identical protein binding
C	0000287	molecular_function	magnesium ion binding
C	0003864	molecular_function	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0015940	biological_process	pantothenate biosynthetic process
C	0016020	cellular_component	membrane
C	0042802	molecular_function	identical protein binding
D	0000287	molecular_function	magnesium ion binding
D	0003864	molecular_function	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0015940	biological_process	pantothenate biosynthetic process
D	0016020	cellular_component	membrane
D	0042802	molecular_function	identical protein binding
E	0000287	molecular_function	magnesium ion binding
E	0003864	molecular_function	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0015940	biological_process	pantothenate biosynthetic process
E	0016020	cellular_component	membrane
E	0042802	molecular_function	identical protein binding
F	0000287	molecular_function	magnesium ion binding
F	0003864	molecular_function	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0015940	biological_process	pantothenate biosynthetic process
F	0016020	cellular_component	membrane
F	0042802	molecular_function	identical protein binding
G	0000287	molecular_function	magnesium ion binding
G	0003864	molecular_function	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0015940	biological_process	pantothenate biosynthetic process
G	0016020	cellular_component	membrane
G	0042802	molecular_function	identical protein binding
H	0000287	molecular_function	magnesium ion binding
H	0003864	molecular_function	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0015940	biological_process	pantothenate biosynthetic process
H	0016020	cellular_component	membrane
H	0042802	molecular_function	identical protein binding
I	0000287	molecular_function	magnesium ion binding
I	0003864	molecular_function	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0015940	biological_process	pantothenate biosynthetic process
I	0016020	cellular_component	membrane
I	0042802	molecular_function	identical protein binding
J	0000287	molecular_function	magnesium ion binding
J	0003864	molecular_function	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0015940	biological_process	pantothenate biosynthetic process
J	0016020	cellular_component	membrane
J	0042802	molecular_function	identical protein binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 266

Chain	Residue
A	ASP45
A	ASP84
A	LYS112
A	KPL265
A	HOH267
A	HOH268

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG B 266

Chain	Residue
B	KPL265
B	HOH267
B	HOH268
B	ASP45
B	ASP84
B	LYS112

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG C 266

Chain	Residue
C	ASP45
C	ASP84
C	LYS112
C	KPL265
C	HOH267
C	HOH268

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG D 266

Chain	Residue
D	ASP45
D	ASP84
D	LYS112
D	KPL265
D	HOH267
D	HOH268

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG E 266

Chain	Residue
E	ASP45
E	ASP84
E	LYS112
E	KPL265
E	HOH267
E	HOH268

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG F 266

Chain	Residue
F	ASP45
F	ASP84
F	LYS112
F	KPL265
F	HOH267
F	HOH268

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG G 266

Chain	Residue
G	ASP45
G	ASP84
G	LYS112
G	KPL265
G	HOH267
G	HOH268

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG H 266

Chain	Residue
H	ASP45
H	ASP84
H	LYS112
H	KPL265
H	HOH267
H	HOH268

site_id	AC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG I 266

Chain	Residue
I	ASP45
I	ASP84
I	LYS112
I	KPL265
I	HOH267
I	HOH268

site_id	BC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG J 266

Chain	Residue
J	ASP45
J	ASP84
J	LYS112
J	KPL265
J	HOH267
J	HOH268

site_id	BC2
Number of Residues	15
Details	BINDING SITE FOR RESIDUE KPL A 265

Chain	Residue
A	THR23
A	LEU42
A	GLY44
A	ASP45
A	SER46
A	ASP84
A	LYS112
A	HIS136
A	PRO141
A	GLU181
A	VAL214
A	MG266
A	HOH268
A	HOH272
A	HOH488

site_id	BC3
Number of Residues	15
Details	BINDING SITE FOR RESIDUE KPL B 265

Chain	Residue
B	THR23
B	LEU42
B	GLY44
B	ASP45
B	SER46
B	ASP84
B	LYS112
B	HIS136
B	PRO141
B	GLU181
B	VAL214
B	MG266
B	HOH268
B	HOH272
B	HOH452

site_id	BC4
Number of Residues	16
Details	BINDING SITE FOR RESIDUE KPL C 265

Chain	Residue
C	ILE212
C	VAL214
C	MG266
C	HOH268
C	HOH271
C	HOH272
C	HOH459
C	THR23
C	LEU42
C	GLY44
C	ASP45
C	SER46
C	ASP84
C	LYS112
C	HIS136
C	GLU181

site_id	BC5
Number of Residues	14
Details	BINDING SITE FOR RESIDUE KPL D 265

Chain	Residue
D	THR23
D	LEU42
D	GLY44
D	ASP45
D	SER46
D	ASP84
D	LYS112
D	HIS136
D	PRO141
D	GLU181
D	VAL214
D	MG266
D	HOH268
D	HOH472

site_id	BC6
Number of Residues	13
Details	BINDING SITE FOR RESIDUE KPL E 265

Chain	Residue
E	THR23
E	LEU42
E	GLY44
E	ASP45
E	SER46
E	ASP84
E	LYS112
E	HIS136
E	GLU181
E	VAL214
E	MG266
E	HOH268
E	HOH271

site_id	BC7
Number of Residues	14
Details	BINDING SITE FOR RESIDUE KPL F 265

Chain	Residue
F	THR23
F	LEU42
F	GLY44
F	ASP45
F	SER46
F	ASP84
F	LYS112
F	HIS136
F	PRO141
F	GLU181
F	VAL214
F	MG266
F	HOH268
F	HOH271

site_id	BC8
Number of Residues	15
Details	BINDING SITE FOR RESIDUE KPL G 265

Chain	Residue
G	THR23
G	LEU42
G	GLY44
G	ASP45
G	SER46
G	ASP84
G	LYS112
G	HIS136
G	GLU181
G	ILE212
G	VAL214
G	MG266
G	HOH268
G	HOH271
G	HOH386

site_id	BC9
Number of Residues	13
Details	BINDING SITE FOR RESIDUE KPL H 265

Chain	Residue
H	THR23
H	LEU42
H	GLY44
H	ASP45
H	SER46
H	ASP84
H	LYS112
H	HIS136
H	PRO141
H	GLU181
H	VAL214
H	MG266
H	HOH268

site_id	CC1
Number of Residues	15
Details	BINDING SITE FOR RESIDUE KPL I 265

Chain	Residue
I	THR23
I	LEU42
I	GLY44
I	ASP45
I	SER46
I	ASP84
I	LYS112
I	HIS136
I	PRO141
I	GLU181
I	ILE212
I	VAL214
I	MG266
I	HOH268
I	HOH271

site_id	CC2
Number of Residues	12
Details	BINDING SITE FOR RESIDUE KPL J 265

Chain	Residue
J	THR23
J	GLY44
J	ASP45
J	SER46
J	ASP84
J	LYS112
J	HIS136
J	GLU181
J	ILE212
J	VAL214
J	MG266
J	HOH268

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	10
Details	Active site: {"description":"Proton acceptor"}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	40
Details	Binding site: {}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	10
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)