1M3J

CRYSTAL form II of perfringolysin O

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005576	cellular_component	extracellular region
A	0008289	molecular_function	lipid binding
A	0015485	molecular_function	cholesterol binding
A	0016020	cellular_component	membrane
A	0020002	cellular_component	host cell plasma membrane
A	0031640	biological_process	killing of cells of another organism
A	0035821	biological_process	modulation of process of another organism
A	0044179	biological_process	hemolysis in another organism
A	0090729	molecular_function	toxin activity
B	0005576	cellular_component	extracellular region
B	0008289	molecular_function	lipid binding
B	0015485	molecular_function	cholesterol binding
B	0016020	cellular_component	membrane
B	0020002	cellular_component	host cell plasma membrane
B	0031640	biological_process	killing of cells of another organism
B	0035821	biological_process	modulation of process of another organism
B	0044179	biological_process	hemolysis in another organism
B	0090729	molecular_function	toxin activity

Functional Information from PROSITE/UniProt

site_id	PS00481
Number of Residues	12
Details	THIOL_CYTOLYSINS Thiol-activated cytolysins signature. RECTGLaWEWWR

Chain	Residue	Details
A	ARG457-ARG468

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	86
Details	TRANSMEM: Beta stranded => ECO:0000250|UniProtKB:Q04IN8

Chain	Residue	Details
A	LYS189-VAL202
A	VAL209-GLU218
A	SER287-ALA296
A	LYS304-SER316
B	LYS189-VAL202
B	VAL209-GLU218
B	SER287-ALA296
B	LYS304-SER316

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site_id	SWS_FT_FI2
Number of Residues	2
Details	SITE: Important for cholesterol binding => ECO:0000305|PubMed:2888650

Chain	Residue	Details
A	CYS459
B	CYS459

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