1M3J
CRYSTAL form II of perfringolysin O
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001897 | biological_process | symbiont-mediated cytolysis of host cell |
| A | 0005576 | cellular_component | extracellular region |
| A | 0008289 | molecular_function | lipid binding |
| A | 0015485 | molecular_function | cholesterol binding |
| A | 0016020 | cellular_component | membrane |
| A | 0020002 | cellular_component | host cell plasma membrane |
| A | 0031640 | biological_process | killing of cells of another organism |
| A | 0033644 | cellular_component | host cell membrane |
| A | 0035821 | biological_process | modulation of process of another organism |
| A | 0044179 | biological_process | hemolysis in another organism |
| A | 0090729 | molecular_function | toxin activity |
| B | 0001897 | biological_process | symbiont-mediated cytolysis of host cell |
| B | 0005576 | cellular_component | extracellular region |
| B | 0008289 | molecular_function | lipid binding |
| B | 0015485 | molecular_function | cholesterol binding |
| B | 0016020 | cellular_component | membrane |
| B | 0020002 | cellular_component | host cell plasma membrane |
| B | 0031640 | biological_process | killing of cells of another organism |
| B | 0033644 | cellular_component | host cell membrane |
| B | 0035821 | biological_process | modulation of process of another organism |
| B | 0044179 | biological_process | hemolysis in another organism |
| B | 0090729 | molecular_function | toxin activity |
Functional Information from PROSITE/UniProt
| site_id | PS00481 |
| Number of Residues | 12 |
| Details | THIOL_CYTOLYSINS Thiol-activated cytolysins signature. RECTGLaWEWWR |
| Chain | Residue | Details |
| A | ARG457-ARG468 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 86 |
| Details | Transmembrane: {"description":"Beta stranded","evidences":[{"source":"UniProtKB","id":"Q04IN8","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 20 |
| Details | Motif: {"description":"Conserved undecapeptide","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Motif: {"description":"Cholesterol binding","evidences":[{"source":"PubMed","id":"20145114","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Site: {"description":"Important for cholesterol binding","evidences":[{"source":"PubMed","id":"2888650","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
