1M3I

Perfringolysin O, new crystal form

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001897	biological_process	symbiont-mediated cytolysis of host cell
A	0005576	cellular_component	extracellular region
A	0008289	molecular_function	lipid binding
A	0015485	molecular_function	cholesterol binding
A	0020002	cellular_component	host cell plasma membrane
A	0031640	biological_process	killing of cells of another organism
A	0035821	biological_process	modulation of process of another organism
A	0044179	biological_process	hemolysis in another organism
A	0090729	molecular_function	toxin activity
A	0141060	biological_process	disruption of anatomical structure in another organism
B	0001897	biological_process	symbiont-mediated cytolysis of host cell
B	0005576	cellular_component	extracellular region
B	0008289	molecular_function	lipid binding
B	0015485	molecular_function	cholesterol binding
B	0020002	cellular_component	host cell plasma membrane
B	0031640	biological_process	killing of cells of another organism
B	0035821	biological_process	modulation of process of another organism
B	0044179	biological_process	hemolysis in another organism
B	0090729	molecular_function	toxin activity
B	0141060	biological_process	disruption of anatomical structure in another organism
C	0001897	biological_process	symbiont-mediated cytolysis of host cell
C	0005576	cellular_component	extracellular region
C	0008289	molecular_function	lipid binding
C	0015485	molecular_function	cholesterol binding
C	0020002	cellular_component	host cell plasma membrane
C	0031640	biological_process	killing of cells of another organism
C	0035821	biological_process	modulation of process of another organism
C	0044179	biological_process	hemolysis in another organism
C	0090729	molecular_function	toxin activity
C	0141060	biological_process	disruption of anatomical structure in another organism
D	0001897	biological_process	symbiont-mediated cytolysis of host cell
D	0005576	cellular_component	extracellular region
D	0008289	molecular_function	lipid binding
D	0015485	molecular_function	cholesterol binding
D	0020002	cellular_component	host cell plasma membrane
D	0031640	biological_process	killing of cells of another organism
D	0035821	biological_process	modulation of process of another organism
D	0044179	biological_process	hemolysis in another organism
D	0090729	molecular_function	toxin activity
D	0141060	biological_process	disruption of anatomical structure in another organism

Functional Information from PROSITE/UniProt

site_id	PS00481
Number of Residues	12
Details	THIOL_CYTOLYSINS Thiol-activated cytolysins signature. RECTGLaWEWWR

Chain	Residue	Details
A	ARG457-ARG468

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	172
Details	Transmembrane: {"description":"Beta stranded","evidences":[{"source":"UniProtKB","id":"Q04IN8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	40
Details	Motif: {"description":"Conserved undecapeptide","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Motif: {"description":"Cholesterol binding","evidences":[{"source":"PubMed","id":"20145114","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	4
Details	Site: {"description":"Important for cholesterol binding","evidences":[{"source":"PubMed","id":"2888650","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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