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1M3I

Perfringolysin O, new crystal form

Functional Information from GO Data
ChainGOidnamespacecontents
A0005576cellular_componentextracellular region
A0008289molecular_functionlipid binding
A0015485molecular_functioncholesterol binding
A0016020cellular_componentmembrane
A0020002cellular_componenthost cell plasma membrane
A0031640biological_processkilling of cells of another organism
A0035821biological_processmodulation of process of another organism
A0044179biological_processhemolysis in another organism
A0090729molecular_functiontoxin activity
B0005576cellular_componentextracellular region
B0008289molecular_functionlipid binding
B0015485molecular_functioncholesterol binding
B0016020cellular_componentmembrane
B0020002cellular_componenthost cell plasma membrane
B0031640biological_processkilling of cells of another organism
B0035821biological_processmodulation of process of another organism
B0044179biological_processhemolysis in another organism
B0090729molecular_functiontoxin activity
C0005576cellular_componentextracellular region
C0008289molecular_functionlipid binding
C0015485molecular_functioncholesterol binding
C0016020cellular_componentmembrane
C0020002cellular_componenthost cell plasma membrane
C0031640biological_processkilling of cells of another organism
C0035821biological_processmodulation of process of another organism
C0044179biological_processhemolysis in another organism
C0090729molecular_functiontoxin activity
D0005576cellular_componentextracellular region
D0008289molecular_functionlipid binding
D0015485molecular_functioncholesterol binding
D0016020cellular_componentmembrane
D0020002cellular_componenthost cell plasma membrane
D0031640biological_processkilling of cells of another organism
D0035821biological_processmodulation of process of another organism
D0044179biological_processhemolysis in another organism
D0090729molecular_functiontoxin activity
Functional Information from PROSITE/UniProt
site_idPS00481
Number of Residues12
DetailsTHIOL_CYTOLYSINS Thiol-activated cytolysins signature. RECTGLaWEWWR
ChainResidueDetails
AARG457-ARG468

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues172
DetailsTRANSMEM: Beta stranded => ECO:0000250|UniProtKB:Q04IN8
ChainResidueDetails
ALYS189-VAL202
CVAL209-GLU218
CSER287-ALA296
CLYS304-SER316
DLYS189-VAL202
DVAL209-GLU218
DSER287-ALA296
DLYS304-SER316
AVAL209-GLU218
ASER287-ALA296
ALYS304-SER316
BLYS189-VAL202
BVAL209-GLU218
BSER287-ALA296
BLYS304-SER316
CLYS189-VAL202

site_idSWS_FT_FI2
Number of Residues4
DetailsSITE: Important for cholesterol binding => ECO:0000305|PubMed:2888650
ChainResidueDetails
ACYS459
BCYS459
CCYS459
DCYS459

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PDB entries from 2024-05-01

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