1M2G
Sir2 homologue-ADP ribose complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0016740 | molecular_function | transferase activity |
| A | 0017136 | molecular_function | histone deacetylase activity, NAD-dependent |
| A | 0034979 | molecular_function | NAD-dependent protein lysine deacetylase activity |
| A | 0036054 | molecular_function | protein-malonyllysine demalonylase activity |
| A | 0036055 | molecular_function | protein-succinyllysine desuccinylase activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0070403 | molecular_function | NAD+ binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN A 999 |
| Chain | Residue |
| A | CYS124 |
| A | CYS127 |
| A | CYS145 |
| A | CYS148 |
| A | SER150 |
| site_id | AC2 |
| Number of Residues | 24 |
| Details | BINDING SITE FOR RESIDUE APR A 1001 |
| Chain | Residue |
| A | THR31 |
| A | PHE32 |
| A | ARG33 |
| A | TRP39 |
| A | GLN98 |
| A | HIS116 |
| A | PHE159 |
| A | GLY185 |
| A | THR186 |
| A | SER187 |
| A | VAL190 |
| A | ASN211 |
| A | PRO212 |
| A | ASP213 |
| A | LYS228 |
| A | ALA229 |
| A | HOH1105 |
| A | HOH1159 |
| A | HOH1160 |
| A | HOH1169 |
| A | GLY20 |
| A | ALA21 |
| A | GLY22 |
| A | GLU26 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 242 |
| Details | Domain: {"description":"Deacetylase sirtuin-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00236","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00236","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 27 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01121","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"11336676","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01121","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01121","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"11336676","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12091395","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
