1M2G
Sir2 homologue-ADP ribose complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0016740 | molecular_function | transferase activity |
| A | 0017136 | molecular_function | NAD-dependent histone deacetylase activity |
| A | 0033558 | molecular_function | protein lysine deacetylase activity |
| A | 0034979 | molecular_function | NAD-dependent protein lysine deacetylase activity |
| A | 0036054 | molecular_function | protein-malonyllysine demalonylase activity |
| A | 0036055 | molecular_function | protein-succinyllysine desuccinylase activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0070403 | molecular_function | NAD+ binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN A 999 |
| Chain | Residue |
| A | CYS124 |
| A | CYS127 |
| A | CYS145 |
| A | CYS148 |
| A | SER150 |
| site_id | AC2 |
| Number of Residues | 24 |
| Details | BINDING SITE FOR RESIDUE APR A 1001 |
| Chain | Residue |
| A | THR31 |
| A | PHE32 |
| A | ARG33 |
| A | TRP39 |
| A | GLN98 |
| A | HIS116 |
| A | PHE159 |
| A | GLY185 |
| A | THR186 |
| A | SER187 |
| A | VAL190 |
| A | ASN211 |
| A | PRO212 |
| A | ASP213 |
| A | LYS228 |
| A | ALA229 |
| A | HOH1105 |
| A | HOH1159 |
| A | HOH1160 |
| A | HOH1169 |
| A | GLY20 |
| A | ALA21 |
| A | GLY22 |
| A | GLU26 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00236 |
| Chain | Residue | Details |
| A | HIS116 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 5 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01121, ECO:0000269|PubMed:11336676 |
| Chain | Residue | Details |
| A | GLY20 | |
| A | GLN98 | |
| A | GLY185 | |
| A | ASN211 | |
| A | ALA229 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01121 |
| Chain | Residue | Details |
| A | TYR64 | |
| A | ARG67 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01121, ECO:0000269|PubMed:11336676, ECO:0000269|PubMed:12091395 |
| Chain | Residue | Details |
| A | CYS124 | |
| A | CYS127 | |
| A | CYS145 | |
| A | CYS148 |
