1M1M

X-RAY CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS BETA-KETOACYL-ACYL CARRIER PROTEIN SYNTHASE III (MTFABH)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000062	molecular_function	fatty-acyl-CoA binding
A	0003824	molecular_function	catalytic activity
A	0004315	molecular_function	3-oxoacyl-[acyl-carrier-protein] synthase activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0006629	biological_process	lipid metabolic process
A	0006631	biological_process	fatty acid metabolic process
A	0006633	biological_process	fatty acid biosynthetic process
A	0008152	biological_process	metabolic process
A	0008610	biological_process	lipid biosynthetic process
A	0016740	molecular_function	transferase activity
A	0016746	molecular_function	acyltransferase activity
A	0030497	biological_process	fatty acid elongation
A	0033818	molecular_function	beta-ketoacyl-acyl-carrier-protein synthase III activity
A	0035336	biological_process	long-chain fatty-acyl-CoA metabolic process
A	0044550	biological_process	secondary metabolite biosynthetic process
A	0061990	molecular_function	beta-ketodecanoyl-[acyl-carrier-protein] synthase activity
B	0000062	molecular_function	fatty-acyl-CoA binding
B	0003824	molecular_function	catalytic activity
B	0004315	molecular_function	3-oxoacyl-[acyl-carrier-protein] synthase activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0006629	biological_process	lipid metabolic process
B	0006631	biological_process	fatty acid metabolic process
B	0006633	biological_process	fatty acid biosynthetic process
B	0008152	biological_process	metabolic process
B	0008610	biological_process	lipid biosynthetic process
B	0016740	molecular_function	transferase activity
B	0016746	molecular_function	acyltransferase activity
B	0030497	biological_process	fatty acid elongation
B	0033818	molecular_function	beta-ketoacyl-acyl-carrier-protein synthase III activity
B	0035336	biological_process	long-chain fatty-acyl-CoA metabolic process
B	0044550	biological_process	secondary metabolite biosynthetic process
B	0061990	molecular_function	beta-ketodecanoyl-[acyl-carrier-protein] synthase activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	ACT_SITE: ACT_SITE => ECO:0000255|HAMAP-Rule:MF_01815, ECO:0000305|PubMed:11278743, ECO:0000305|PubMed:16040614

Chain	Residue	Details
A	CYS123
A	HIS259
A	ASN290
B	CYS123
B	HIS259
B	ASN290

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site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:15713483, ECO:0000305|PubMed:18096200, ECO:0007744|PDB:1U6S, ECO:0007744|PDB:2QX1

Chain	Residue	Details
A	SER39
B	SER39

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site_id	SWS_FT_FI3
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:15713483, ECO:0000305|PubMed:11278743, ECO:0007744|PDB:1HZP, ECO:0007744|PDB:1U6S

Chain	Residue	Details
A	CYS123
B	CYS123

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site_id	SWS_FT_FI4
Number of Residues	4
Details	BINDING: BINDING => ECO:0000305|PubMed:11278743, ECO:0007744|PDB:1HZP

Chain	Residue	Details
A	ASN290
A	TYR320
B	ASN290
B	TYR320

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site_id	SWS_FT_FI5
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:15713483, ECO:0007744|PDB:1U6S

Chain	Residue	Details
A	ALA322
B	ALA322

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site_id	SWS_FT_FI6
Number of Residues	2
Details	MOD_RES: N-acetylthreonine => ECO:0007744|PubMed:21969609

Chain	Residue	Details
A	THR3
B	THR3

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site_id	SWS_FT_FI7
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0000269|PubMed:19074144

Chain	Residue	Details
A	THR46
B	THR46

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