1M1E
Beta-catenin armadillo repeat domain bound to ICAT
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0007155 | biological_process | cell adhesion |
| A | 0045296 | molecular_function | cadherin binding |
| B | 0000122 | biological_process | negative regulation of transcription by RNA polymerase II |
| B | 0001223 | molecular_function | transcription coactivator binding |
| B | 0001658 | biological_process | branching involved in ureteric bud morphogenesis |
| B | 0002528 | biological_process | regulation of vascular permeability involved in acute inflammatory response |
| B | 0005515 | molecular_function | protein binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005654 | cellular_component | nucleoplasm |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0008013 | molecular_function | beta-catenin binding |
| B | 0008285 | biological_process | negative regulation of cell population proliferation |
| B | 0009952 | biological_process | anterior/posterior pattern specification |
| B | 0016055 | biological_process | Wnt signaling pathway |
| B | 0030178 | biological_process | negative regulation of Wnt signaling pathway |
| B | 0030877 | cellular_component | beta-catenin destruction complex |
| B | 0031333 | biological_process | negative regulation of protein-containing complex assembly |
| B | 0032991 | cellular_component | protein-containing complex |
| B | 0045657 | biological_process | positive regulation of monocyte differentiation |
| B | 0045669 | biological_process | positive regulation of osteoblast differentiation |
| B | 0048662 | biological_process | negative regulation of smooth muscle cell proliferation |
| B | 0060070 | biological_process | canonical Wnt signaling pathway |
| B | 0060633 | biological_process | negative regulation of transcription initiation by RNA polymerase II |
| B | 0070016 | molecular_function | armadillo repeat domain binding |
| B | 0072201 | biological_process | negative regulation of mesenchymal cell proliferation |
| B | 0090090 | biological_process | negative regulation of canonical Wnt signaling pathway |
| B | 0140416 | molecular_function | transcription regulator inhibitor activity |
| B | 1990711 | cellular_component | beta-catenin-ICAT complex |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 40 |
| Details | Repeat: {"description":"ARM 1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 41 |
| Details | Repeat: {"description":"ARM 2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 41 |
| Details | Repeat: {"description":"ARM 3"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 41 |
| Details | Repeat: {"description":"ARM 4"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 41 |
| Details | Repeat: {"description":"ARM 5"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 28 |
| Details | Repeat: {"description":"ARM 6"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 41 |
| Details | Repeat: {"description":"ARM 7"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 42 |
| Details | Repeat: {"description":"ARM 8"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 41 |
| Details | Repeat: {"description":"ARM 9"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 42 |
| Details | Repeat: {"description":"ARM 11"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 29 |
| Details | Repeat: {"description":"ARM 12"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 22 |
| Details | Region: {"description":"Interaction with BCL9","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17242355","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21183079","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine; by CDK5","evidences":[{"source":"UniProtKB","id":"P35222","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P35222","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI16 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"S-nitrosocysteine","evidences":[{"source":"PubMed","id":"20705246","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
