1LW5
X-ray structure of L-Threonine Aldolase (low-specificity) in complex with glycine
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005829 | cellular_component | cytosol |
| A | 0006520 | biological_process | amino acid metabolic process |
| A | 0006545 | biological_process | glycine biosynthetic process |
| A | 0006567 | biological_process | threonine catabolic process |
| A | 0008732 | molecular_function | L-allo-threonine aldolase activity |
| A | 0016829 | molecular_function | lyase activity |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0005829 | cellular_component | cytosol |
| B | 0006520 | biological_process | amino acid metabolic process |
| B | 0006545 | biological_process | glycine biosynthetic process |
| B | 0006567 | biological_process | threonine catabolic process |
| B | 0008732 | molecular_function | L-allo-threonine aldolase activity |
| B | 0016829 | molecular_function | lyase activity |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0005829 | cellular_component | cytosol |
| C | 0006520 | biological_process | amino acid metabolic process |
| C | 0006545 | biological_process | glycine biosynthetic process |
| C | 0006567 | biological_process | threonine catabolic process |
| C | 0008732 | molecular_function | L-allo-threonine aldolase activity |
| C | 0016829 | molecular_function | lyase activity |
| C | 0046872 | molecular_function | metal ion binding |
| D | 0005829 | cellular_component | cytosol |
| D | 0006520 | biological_process | amino acid metabolic process |
| D | 0006545 | biological_process | glycine biosynthetic process |
| D | 0006567 | biological_process | threonine catabolic process |
| D | 0008732 | molecular_function | L-allo-threonine aldolase activity |
| D | 0016829 | molecular_function | lyase activity |
| D | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA C 1004 |
| Chain | Residue |
| B | THR8 |
| B | THR10 |
| B | SER198 |
| B | ALA203 |
| C | GLN232 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA A 1005 |
| Chain | Residue |
| D | GLN232 |
| A | THR8 |
| A | THR10 |
| A | SER198 |
| A | ALA203 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA A 1006 |
| Chain | Residue |
| A | GLN232 |
| D | THR8 |
| D | THR10 |
| D | SER198 |
| D | ALA203 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA B 1007 |
| Chain | Residue |
| B | GLN232 |
| C | THR8 |
| C | THR10 |
| C | SER198 |
| C | ALA203 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE CA B 1008 |
| Chain | Residue |
| A | ASP322 |
| B | ASN326 |
| B | GLU329 |
| B | HOH1038 |
| B | HOH1142 |
| B | HOH1146 |
| B | HOH1203 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA D 1009 |
| Chain | Residue |
| A | ASN288 |
| A | SER343 |
| D | ASN326 |
| D | GLU329 |
| D | HOH1214 |
| D | HOH1215 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CL A 1010 |
| Chain | Residue |
| A | GLN71 |
| A | ARG72 |
| A | HOH1207 |
| B | GLN71 |
| B | ARG72 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL D 1011 |
| Chain | Residue |
| C | ARG72 |
| D | GLN71 |
| D | ARG72 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL B 1012 |
| Chain | Residue |
| B | LYS11 |
| B | ARG17 |
| C | VAL25 |
| site_id | BC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL B 1013 |
| Chain | Residue |
| B | GLU24 |
| B | VAL25 |
| C | LYS11 |
| C | ARG17 |
| site_id | BC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL D 1014 |
| Chain | Residue |
| A | LYS11 |
| A | ARG17 |
| D | VAL25 |
| site_id | BC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL D 1015 |
| Chain | Residue |
| A | GLU24 |
| A | VAL25 |
| D | LYS11 |
| D | ARG17 |
| site_id | BC4 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE PLG B 1000 |
| Chain | Residue |
| B | SER6 |
| B | SER57 |
| B | GLY58 |
| B | THR59 |
| B | HIS83 |
| B | GLU135 |
| B | ASP168 |
| B | ALA170 |
| B | ARG171 |
| B | MSE194 |
| B | LLP199 |
| B | ARG316 |
| B | HOH1031 |
| B | HOH1037 |
| B | HOH1046 |
| B | HOH1073 |
| B | HOH1167 |
| C | ARG231 |
| C | HOH1066 |
| site_id | BC5 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE PLG C 1001 |
| Chain | Residue |
| B | ARG231 |
| B | HOH1043 |
| C | SER6 |
| C | SER57 |
| C | GLY58 |
| C | THR59 |
| C | ASN62 |
| C | HIS83 |
| C | GLU135 |
| C | ASN139 |
| C | ASP168 |
| C | ALA170 |
| C | ARG171 |
| C | MSE194 |
| C | LLP199 |
| C | ARG316 |
| C | HOH1019 |
| C | HOH1022 |
| C | HOH1030 |
| C | HOH1042 |
| C | HOH1118 |
| C | HOH1143 |
| C | HOH1182 |
| site_id | BC6 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE PLG D 1002 |
| Chain | Residue |
| A | HOH1105 |
| D | SER6 |
| D | SER57 |
| D | GLY58 |
| D | THR59 |
| D | ASN62 |
| D | HIS83 |
| D | GLU135 |
| D | ASN139 |
| D | ASP168 |
| D | ALA170 |
| D | ARG171 |
| D | MSE194 |
| D | LLP199 |
| D | ARG316 |
| D | HOH1062 |
| D | HOH1079 |
| D | HOH1093 |
| D | HOH1102 |
| D | HOH1126 |
| A | ARG231 |
| A | HOH1013 |
| site_id | BC7 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE PLP B 1003 |
| Chain | Residue |
| B | SER57 |
| B | GLY58 |
| B | THR59 |
| B | ASN62 |
| B | HIS83 |
| B | GLU88 |
| B | GLU135 |
| B | ASP168 |
| B | ALA170 |
| B | ARG171 |
| B | LLP199 |
| B | HOH1031 |
| B | HOH1037 |
| B | HOH1046 |
| B | HOH1167 |
| C | ARG231 |
| C | HOH1066 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1ax4 |
| Chain | Residue | Details |
| A | TYR30 |
| site_id | CSA10 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ax4 |
| Chain | Residue | Details |
| B | HIS83 | |
| B | ASP168 |
| site_id | CSA11 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ax4 |
| Chain | Residue | Details |
| C | HIS83 | |
| C | ASP168 |
| site_id | CSA12 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ax4 |
| Chain | Residue | Details |
| D | HIS83 | |
| D | ASP168 |
| site_id | CSA13 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ax4 |
| Chain | Residue | Details |
| A | GLU135 | |
| A | HIS83 | |
| A | ASP168 |
| site_id | CSA14 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ax4 |
| Chain | Residue | Details |
| B | GLU135 | |
| B | HIS83 | |
| B | ASP168 |
| site_id | CSA15 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ax4 |
| Chain | Residue | Details |
| C | GLU135 | |
| C | HIS83 | |
| C | ASP168 |
| site_id | CSA16 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ax4 |
| Chain | Residue | Details |
| D | GLU135 | |
| D | HIS83 | |
| D | ASP168 |
| site_id | CSA17 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ax4 |
| Chain | Residue | Details |
| A | PHE85 | |
| A | ASP168 |
| site_id | CSA18 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ax4 |
| Chain | Residue | Details |
| B | PHE85 | |
| B | ASP168 |
| site_id | CSA19 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ax4 |
| Chain | Residue | Details |
| C | PHE85 | |
| C | ASP168 |
| site_id | CSA2 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1ax4 |
| Chain | Residue | Details |
| B | TYR30 |
| site_id | CSA20 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ax4 |
| Chain | Residue | Details |
| D | PHE85 | |
| D | ASP168 |
| site_id | CSA21 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1ax4 |
| Chain | Residue | Details |
| A | GLU32 |
| site_id | CSA22 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1ax4 |
| Chain | Residue | Details |
| B | GLU32 |
| site_id | CSA23 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1ax4 |
| Chain | Residue | Details |
| C | GLU32 |
| site_id | CSA24 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1ax4 |
| Chain | Residue | Details |
| D | GLU32 |
| site_id | CSA3 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1ax4 |
| Chain | Residue | Details |
| C | TYR30 |
| site_id | CSA4 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1ax4 |
| Chain | Residue | Details |
| D | TYR30 |
| site_id | CSA5 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ax4 |
| Chain | Residue | Details |
| A | TRP86 | |
| A | ASP168 |
| site_id | CSA6 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ax4 |
| Chain | Residue | Details |
| B | TRP86 | |
| B | ASP168 |
| site_id | CSA7 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ax4 |
| Chain | Residue | Details |
| C | TRP86 | |
| C | ASP168 |
| site_id | CSA8 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ax4 |
| Chain | Residue | Details |
| D | TRP86 | |
| D | ASP168 |
| site_id | CSA9 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ax4 |
| Chain | Residue | Details |
| A | HIS83 | |
| A | ASP168 |
