1LW3
Crystal Structure of Myotubularin-related protein 2 complexed with phosphate
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0002091 | biological_process | negative regulation of receptor internalization |
| A | 0004438 | molecular_function | phosphatidylinositol-3-phosphate phosphatase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005774 | cellular_component | vacuolar membrane |
| A | 0005829 | cellular_component | cytosol |
| A | 0006629 | biological_process | lipid metabolic process |
| A | 0006661 | biological_process | phosphatidylinositol biosynthetic process |
| A | 0008021 | cellular_component | synaptic vesicle |
| A | 0010008 | cellular_component | endosome membrane |
| A | 0014069 | cellular_component | postsynaptic density |
| A | 0016020 | cellular_component | membrane |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0030424 | cellular_component | axon |
| A | 0030425 | cellular_component | dendrite |
| A | 0031901 | cellular_component | early endosome membrane |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0043197 | cellular_component | dendritic spine |
| A | 0045806 | biological_process | negative regulation of endocytosis |
| A | 0046856 | biological_process | phosphatidylinositol dephosphorylation |
| A | 0048471 | cellular_component | perinuclear region of cytoplasm |
| A | 0052629 | molecular_function | phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity |
| A | 0052866 | molecular_function | phosphatidylinositol phosphate phosphatase activity |
| A | 0060304 | biological_process | regulation of phosphatidylinositol dephosphorylation |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0090394 | biological_process | negative regulation of excitatory postsynaptic potential |
| A | 0097060 | cellular_component | synaptic membrane |
| A | 0097062 | biological_process | dendritic spine maintenance |
| A | 2000643 | biological_process | positive regulation of early endosome to late endosome transport |
| A | 2000645 | biological_process | negative regulation of receptor catabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE PO4 A 655 |
| Chain | Residue |
| A | SER417 |
| A | SER418 |
| A | ASP419 |
| A | GLY420 |
| A | TRP421 |
| A | ASP422 |
| A | ARG423 |
| A | HOH1001 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PO4 A 656 |
| Chain | Residue |
| A | TRP421 |
| A | ARG463 |
| A | ASP475 |
| A | HOH1320 |
| A | ASP419 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PO4 A 657 |
| Chain | Residue |
| A | ARG322 |
| A | ASN326 |
| A | ASN330 |
| A | ASN355 |
| A | SER418 |
| A | ARG423 |
| A | HOH1130 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 375 |
| Details | Domain: {"description":"Myotubularin phosphatase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00669","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Phosphocysteine intermediate","evidences":[{"source":"PubMed","id":"14690594","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16410353","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 10 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"16410353","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"1ZSQ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"16410353","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"1ZVR","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
