1LTX

Structure of Rab Escort Protein-1 in complex with Rab geranylgeranyl transferase and isoprenoid

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004659	molecular_function	prenyltransferase activity
A	0004661	molecular_function	protein geranylgeranyltransferase activity
A	0004663	molecular_function	Rab geranylgeranyltransferase activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005968	cellular_component	Rab-protein geranylgeranyltransferase complex
A	0008270	molecular_function	zinc ion binding
A	0008318	molecular_function	protein prenyltransferase activity
A	0018342	biological_process	protein prenylation
A	0018344	biological_process	protein geranylgeranylation
A	0031267	molecular_function	small GTPase binding
B	0003824	molecular_function	catalytic activity
B	0004659	molecular_function	prenyltransferase activity
B	0004661	molecular_function	protein geranylgeranyltransferase activity
B	0004663	molecular_function	Rab geranylgeranyltransferase activity
B	0005515	molecular_function	protein binding
B	0005968	cellular_component	Rab-protein geranylgeranyltransferase complex
B	0008270	molecular_function	zinc ion binding
B	0008318	molecular_function	protein prenyltransferase activity
B	0018344	biological_process	protein geranylgeranylation
B	0019840	molecular_function	isoprenoid binding
B	0031267	molecular_function	small GTPase binding
B	0046872	molecular_function	metal ion binding
R	0001568	biological_process	blood vessel development
R	0005092	molecular_function	GDP-dissociation inhibitor activity
R	0005096	molecular_function	GTPase activator activity
R	0005515	molecular_function	protein binding
R	0005634	cellular_component	nucleus
R	0005737	cellular_component	cytoplasm
R	0005829	cellular_component	cytosol
R	0005968	cellular_component	Rab-protein geranylgeranyltransferase complex
R	0006612	biological_process	protein targeting to membrane
R	0006886	biological_process	intracellular protein transport
R	0007264	biological_process	small GTPase-mediated signal transduction
R	0016192	biological_process	vesicle-mediated transport
R	0018344	biological_process	protein geranylgeranylation
R	0031267	molecular_function	small GTPase binding
R	0044877	molecular_function	protein-containing complex binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN B 900

Chain	Residue
B	ASP238
B	CYS240
B	HIS290

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL R 901

Chain	Residue
R	TYR234
R	GLY580
R	ASN581
R	HOH916

---

site_id	AC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE FAR P 1428

Chain	Residue
B	GLN103
B	ARG144
B	TYR195
P	ALA9
P	ALA11
P	ALA12
A	TYR107
B	TYR51

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:18756270, ECO:0007744|PDB:3DST, ECO:0007744|PDB:3DSX

Chain	Residue	Details
B	HIS190

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:18399557, ECO:0000269|PubMed:18756270, ECO:0000269|PubMed:19894725, ECO:0000269|PubMed:22480322, ECO:0000269|PubMed:22963166

Chain	Residue	Details
B	ASP238
B	CYS240
B	HIS290

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	BINDING: BINDING => ECO:0007744|PDB:3DST, ECO:0007744|PDB:3DSV

Chain	Residue	Details
B	TYR241

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: N-acetylglycine => ECO:0000250|UniProtKB:P53611

Chain	Residue	Details
B	GLY2

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P53611

Chain	Residue	Details
B	THR3

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1d8d

Chain	Residue	Details
A	LYS105
B	TYR241

---

site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1d8d

Chain	Residue	Details
A	SER176

---