1LT8
Reduced Homo sapiens Betaine-Homocysteine S-Methyltransferase in Complex with S-(delta-carboxybutyl)-L-Homocysteine
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005634 | cellular_component | nucleus |
| A | 0005829 | cellular_component | cytosol |
| A | 0006479 | biological_process | protein methylation |
| A | 0006575 | biological_process | modified amino acid metabolic process |
| A | 0006577 | biological_process | amino-acid betaine metabolic process |
| A | 0006579 | biological_process | amino-acid betaine catabolic process |
| A | 0008168 | molecular_function | methyltransferase activity |
| A | 0008172 | molecular_function | S-methyltransferase activity |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0009086 | biological_process | methionine biosynthetic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0032259 | biological_process | methylation |
| A | 0046500 | biological_process | S-adenosylmethionine metabolic process |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0047150 | molecular_function | betaine-homocysteine S-methyltransferase activity |
| A | 0050666 | biological_process | obsolete regulation of homocysteine metabolic process |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0071266 | biological_process | 'de novo' L-methionine biosynthetic process |
| A | 0071267 | biological_process | L-methionine salvage |
| B | 0005634 | cellular_component | nucleus |
| B | 0005829 | cellular_component | cytosol |
| B | 0006479 | biological_process | protein methylation |
| B | 0006575 | biological_process | modified amino acid metabolic process |
| B | 0006577 | biological_process | amino-acid betaine metabolic process |
| B | 0006579 | biological_process | amino-acid betaine catabolic process |
| B | 0008168 | molecular_function | methyltransferase activity |
| B | 0008172 | molecular_function | S-methyltransferase activity |
| B | 0008270 | molecular_function | zinc ion binding |
| B | 0009086 | biological_process | methionine biosynthetic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0032259 | biological_process | methylation |
| B | 0046500 | biological_process | S-adenosylmethionine metabolic process |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0047150 | molecular_function | betaine-homocysteine S-methyltransferase activity |
| B | 0050666 | biological_process | obsolete regulation of homocysteine metabolic process |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 0071266 | biological_process | 'de novo' L-methionine biosynthetic process |
| B | 0071267 | biological_process | L-methionine salvage |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 501 |
| Chain | Residue |
| A | CYS217 |
| A | CYS299 |
| A | CYS300 |
| A | CBH601 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 502 |
| Chain | Residue |
| B | CYS217 |
| B | CYS299 |
| B | CYS300 |
| B | CBH602 |
| site_id | AC3 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE CBH A 601 |
| Chain | Residue |
| A | GLY28 |
| A | PHE29 |
| A | VAL30 |
| A | TRP44 |
| A | PHE76 |
| A | TYR77 |
| A | GLU159 |
| A | TYR160 |
| A | ILE262 |
| A | PHE267 |
| A | CYS299 |
| A | CYS300 |
| A | ZN501 |
| A | HOH708 |
| A | HOH788 |
| A | HOH858 |
| A | HOH862 |
| B | HIS338 |
| A | GLY27 |
| site_id | AC4 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE CBH B 602 |
| Chain | Residue |
| A | HIS338 |
| B | GLY27 |
| B | GLY28 |
| B | PHE29 |
| B | VAL30 |
| B | TRP44 |
| B | GLN72 |
| B | PHE76 |
| B | TYR77 |
| B | GLU159 |
| B | TYR160 |
| B | PHE267 |
| B | CYS299 |
| B | CYS300 |
| B | ZN502 |
| B | HOH714 |
| B | HOH871 |
| B | HOH878 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE CIT A 701 |
| Chain | Residue |
| A | ASP220 |
| A | HIS252 |
| A | ARG356 |
| B | GLY360 |
| B | PRO362 |
| B | TYR363 |
| B | LYS369 |
| B | HOH710 |
| site_id | AC6 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE CIT B 702 |
| Chain | Residue |
| A | GLY360 |
| A | PRO362 |
| A | TYR363 |
| A | LYS369 |
| A | HOH706 |
| B | ASP220 |
| B | HIS252 |
| B | ARG356 |
| B | HOH828 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00333","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"12220488","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1LT8","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"O35490","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"O09171","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
