1LOS
crystal structure of orotidine monophosphate decarboxylase mutant deltaR203A complexed with 6-azaUMP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004590 | molecular_function | orotidine-5'-phosphate decarboxylase activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
| A | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
| A | 0016829 | molecular_function | lyase activity |
| A | 0016831 | molecular_function | carboxy-lyase activity |
| A | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
| B | 0004590 | molecular_function | orotidine-5'-phosphate decarboxylase activity |
| B | 0005829 | cellular_component | cytosol |
| B | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
| B | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
| B | 0016829 | molecular_function | lyase activity |
| B | 0016831 | molecular_function | carboxy-lyase activity |
| B | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
| C | 0004590 | molecular_function | orotidine-5'-phosphate decarboxylase activity |
| C | 0005829 | cellular_component | cytosol |
| C | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
| C | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
| C | 0016829 | molecular_function | lyase activity |
| C | 0016831 | molecular_function | carboxy-lyase activity |
| C | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
| D | 0004590 | molecular_function | orotidine-5'-phosphate decarboxylase activity |
| D | 0005829 | cellular_component | cytosol |
| D | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
| D | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
| D | 0016829 | molecular_function | lyase activity |
| D | 0016831 | molecular_function | carboxy-lyase activity |
| D | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE UP6 A 5001 |
| Chain | Residue |
| A | ALA18 |
| A | HOH4016 |
| A | HOH4024 |
| A | HOH4033 |
| A | HOH4036 |
| A | HOH4037 |
| A | HOH4087 |
| A | HOH4088 |
| A | HOH4206 |
| B | ASP1075 |
| B | ILE1076 |
| A | ASP20 |
| B | THR1079 |
| A | LYS42 |
| A | LYS72 |
| A | MET126 |
| A | SER127 |
| A | PRO180 |
| A | GLY202 |
| A | ALA203 |
| site_id | AC2 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE UP6 B 5002 |
| Chain | Residue |
| A | ASP75 |
| A | ILE76 |
| A | THR79 |
| B | ALA1018 |
| B | ASP1020 |
| B | LYS1042 |
| B | LYS1072 |
| B | MET1126 |
| B | SER1127 |
| B | PRO1180 |
| B | GLY1202 |
| B | ALA1203 |
| B | HOH4057 |
| B | HOH4061 |
| B | HOH4069 |
| B | HOH4148 |
| B | HOH4152 |
| site_id | AC3 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE UP6 C 5003 |
| Chain | Residue |
| C | ALA2018 |
| C | ASP2020 |
| C | LYS2042 |
| C | LYS2072 |
| C | MET2126 |
| C | SER2127 |
| C | PRO2180 |
| C | GLY2202 |
| C | ALA2203 |
| C | HOH4154 |
| C | HOH4156 |
| C | HOH4169 |
| D | ASP3075 |
| D | ILE3076 |
| D | THR3079 |
| site_id | AC4 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE UP6 D 5004 |
| Chain | Residue |
| C | ASP2075 |
| C | ILE2076 |
| C | THR2079 |
| D | ASP3020 |
| D | LYS3042 |
| D | LYS3072 |
| D | MET3126 |
| D | SER3127 |
| D | PRO3180 |
| D | GLY3202 |
| D | ALA3203 |
| D | HOH4054 |
| D | HOH4161 |
| D | HOH4193 |
| D | HOH4195 |
| D | HOH4205 |
Functional Information from PROSITE/UniProt
| site_id | PS00156 |
| Number of Residues | 14 |
| Details | OMPDECASE Orotidine 5'-phosphate decarboxylase active site. IIaDfKvaDIPeTN |
| Chain | Residue | Details |
| A | ILE67-ASN80 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Proton donor"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 56 |
| Details | Binding site: {} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1dbt |
| Chain | Residue | Details |
| A | LYS72 | |
| A | ASP70 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1dbt |
| Chain | Residue | Details |
| B | ASP1070 | |
| B | LYS1072 |
| site_id | CSA3 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1dbt |
| Chain | Residue | Details |
| C | LYS2072 | |
| C | ASP2070 |
| site_id | CSA4 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1dbt |
| Chain | Residue | Details |
| D | ASP3070 | |
| D | LYS3072 |
| site_id | CSA5 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1dbt |
| Chain | Residue | Details |
| A | LYS42 | |
| A | ASP75 | |
| A | LYS72 | |
| A | ASP70 |
| site_id | CSA6 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1dbt |
| Chain | Residue | Details |
| B | ASP1070 | |
| B | ASP1075 | |
| B | LYS1072 | |
| B | LYS1042 |
| site_id | CSA7 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1dbt |
| Chain | Residue | Details |
| C | LYS2042 | |
| C | LYS2072 | |
| C | ASP2075 | |
| C | ASP2070 |
| site_id | CSA8 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1dbt |
| Chain | Residue | Details |
| D | LYS3042 | |
| D | LYS3072 | |
| D | ASP3070 | |
| D | ASP3075 |
