1LLM

Crystal Structure of a Zif23-GCN4 Chimera Bound to DNA

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0003700	molecular_function	DNA-binding transcription factor activity
C	0006355	biological_process	regulation of DNA-templated transcription
D	0003700	molecular_function	DNA-binding transcription factor activity
D	0006355	biological_process	regulation of DNA-templated transcription

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 301

Chain	Residue
C	CYS106
C	CYS109
C	HIS122
C	HIS126

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site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 302

Chain	Residue
C	CYS134
C	CYS137
C	HIS150
C	HIS155

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site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN D 303

Chain	Residue
D	CYS209
D	HIS222
D	HIS226
D	CYS206

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site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN D 304

Chain	Residue
D	CYS234
D	CYS237
D	HIS250
D	HIS255

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Functional Information from PROSITE/UniProt

site_id	PS00028
Number of Residues	21
Details	ZINC_FINGER_C2H2_1 Zinc finger C2H2 type domain signature. Cri..CmrnFsrsdhlttHirt..H

Chain	Residue	Details
C	CYS106-HIS126
C	CYS134-HIS155

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	44
Details	ZN_FING: C2H2-type 2 => ECO:0000255|PROSITE-ProRule:PRU00042

Chain	Residue	Details
C	PHE104-HIS126
D	PHE204-HIS226

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site_id	SWS_FT_FI2
Number of Residues	10
Details	SITE: Interaction with DNA => ECO:0000269|PubMed:2028256, ECO:0000269|PubMed:8939742, ECO:0007744|PDB:1AAY, ECO:0007744|PDB:1ZAA

Chain	Residue	Details
C	ARG111
D	ARG249
C	ARG115
C	ARG139
C	ARG143
C	ARG149
D	ARG211
D	ARG215
D	ARG239
D	ARG243

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