Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003700 | molecular_function | DNA-binding transcription factor activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| B | 0003677 | molecular_function | DNA binding |
| B | 0003700 | molecular_function | DNA-binding transcription factor activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0006355 | biological_process | regulation of DNA-templated transcription |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL B 4001 |
| Chain | Residue |
| B | THR2154 |
| B | ASN2155 |
| B | ASN2155 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL B 4002 |
| Chain | Residue |
| B | GLN2158 |
| B | HOH3056 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL A 4003 |
| Chain | Residue |
| A | ALA1115 |
| A | GLU1116 |
| A | GLY1138 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL B 4004 |
| Chain | Residue |
| B | ALA2115 |
| B | GLU2116 |
| B | GLY2138 |
| B | ASN2112 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL B 4005 |
| Chain | Residue |
| B | ARG2142 |
| B | THR2169 |
| B | VAL2170 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | ASN1112 | |
| A | ARG1139 | |
| A | VAL1170 | |
| B | ASN2112 | |
| B | GLU2116 | |
| B | ARG2139 | |
| B | VAL2170 | |
| A | GLU1116 | |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | SITE: Breakpoint for translocation to form AML1-EMV-1 (or AML1-EAP) in CML and T-MDS, to form AML1-MTG8 (ETO) in AML-M2, to form AML1-CBFA2T3 in therapy-related myeloid malignancies, to form AML1-MECOM in CML and to form type I MACROD1-RUNX1 fusion protein |
| Chain | Residue | Details |
| A | ARG1177 | |
| B | ARG2177 | |
