1LFD
CRYSTAL STRUCTURE OF THE ACTIVE RAS PROTEIN COMPLEXED WITH THE RAS-INTERACTING DOMAIN OF RALGDS
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0007165 | biological_process | signal transduction |
| B | 0003924 | molecular_function | GTPase activity |
| B | 0005525 | molecular_function | GTP binding |
| B | 0007165 | biological_process | signal transduction |
| B | 0016020 | cellular_component | membrane |
| C | 0007165 | biological_process | signal transduction |
| D | 0003924 | molecular_function | GTPase activity |
| D | 0005525 | molecular_function | GTP binding |
| D | 0007165 | biological_process | signal transduction |
| D | 0016020 | cellular_component | membrane |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG B 1373 |
| Chain | Residue |
| B | SER217 |
| B | ASP233 |
| B | THR235 |
| B | GNP1380 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG D 2373 |
| Chain | Residue |
| D | SER217 |
| D | ASP233 |
| D | THR235 |
| D | GNP2380 |
| site_id | AC3 |
| Number of Residues | 27 |
| Details | BINDING SITE FOR RESIDUE GNP B 1380 |
| Chain | Residue |
| B | GLY213 |
| B | VAL214 |
| B | GLY215 |
| B | LYS216 |
| B | SER217 |
| B | ALA218 |
| B | PHE228 |
| B | ASP230 |
| B | LYS231 |
| B | PRO234 |
| B | THR235 |
| B | GLY260 |
| B | ASN316 |
| B | LYS317 |
| B | ASP319 |
| B | LEU320 |
| B | SER345 |
| B | ALA346 |
| B | LYS347 |
| B | MG1373 |
| B | HOH1392 |
| B | HOH1399 |
| B | HOH1424 |
| B | HOH1453 |
| B | HOH1473 |
| D | TYR232 |
| B | GLY212 |
| site_id | AC4 |
| Number of Residues | 27 |
| Details | BINDING SITE FOR RESIDUE GNP D 2380 |
| Chain | Residue |
| B | TYR232 |
| B | HOH1443 |
| D | GLY212 |
| D | GLY213 |
| D | VAL214 |
| D | GLY215 |
| D | LYS216 |
| D | SER217 |
| D | ALA218 |
| D | PHE228 |
| D | ASP230 |
| D | LYS231 |
| D | PRO234 |
| D | THR235 |
| D | GLY260 |
| D | ASN316 |
| D | LYS317 |
| D | ASP319 |
| D | LEU320 |
| D | SER345 |
| D | ALA346 |
| D | LYS347 |
| D | MG2373 |
| D | HOH2381 |
| D | HOH2388 |
| D | HOH2397 |
| D | HOH2461 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"Q12967","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 16 |
| Details | Motif: {"description":"Effector region"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 34 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"16698776","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35522713","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N-acetylmethionine; in GTPase HRas; alternate","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"FEB-2008","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Calvo F.","Kolch W."]}}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N-acetylthreonine; in GTPase HRas, N-terminally processed","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"FEB-2008","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Calvo F.","Kolch W."]}}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"S-nitrosocysteine","evidences":[{"source":"PubMed","id":"9020151","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"(Microbial infection) O-linked (Glc) threonine; by P.sordellii toxin TcsL","evidences":[{"source":"PubMed","id":"19744486","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8626575","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8626586","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9632667","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1ksj |
| Chain | Residue | Details |
| B | GLN261 |
| site_id | CSA2 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1ksj |
| Chain | Residue | Details |
| D | GLN261 |
