Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1LCP

BOVINE LENS LEUCINE AMINOPEPTIDASE COMPLEXED WITH L-LEUCINE PHOSPHONIC ACID

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004177	molecular_function	aminopeptidase activity
A	0004180	molecular_function	carboxypeptidase activity
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0006508	biological_process	proteolysis
A	0008233	molecular_function	peptidase activity
A	0016787	molecular_function	hydrolase activity
A	0016805	molecular_function	dipeptidase activity
A	0019538	biological_process	protein metabolic process
A	0030145	molecular_function	manganese ion binding
A	0046872	molecular_function	metal ion binding
A	0070006	molecular_function	metalloaminopeptidase activity
A	0097718	molecular_function	disordered domain specific binding
B	0004177	molecular_function	aminopeptidase activity
B	0004180	molecular_function	carboxypeptidase activity
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0006508	biological_process	proteolysis
B	0008233	molecular_function	peptidase activity
B	0016787	molecular_function	hydrolase activity
B	0016805	molecular_function	dipeptidase activity
B	0019538	biological_process	protein metabolic process
B	0030145	molecular_function	manganese ion binding
B	0046872	molecular_function	metal ion binding
B	0070006	molecular_function	metalloaminopeptidase activity
B	0097718	molecular_function	disordered domain specific binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN A 488

Chain	Residue
A	ASP255
A	ASP332
A	GLU334
A	ZN489
A	PLU500

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ZN A 489

Chain	Residue
A	LYS250
A	ASP255
A	ASP273
A	GLU334
A	ZN488
A	PLU500

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ZN A 490

Chain	Residue
A	LEU170
A	MET171
A	THR173
A	ARG271
A	MET274
A	HOH525

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN B 488

Chain	Residue
B	ASP255
B	ASP332
B	GLU334
B	ZN489
B	PLU500

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ZN B 489

Chain	Residue
B	LYS250
B	ASP255
B	ASP273
B	GLU334
B	ZN488
B	PLU500

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ZN B 490

Chain	Residue
B	LEU170
B	MET171
B	THR173
B	ARG271
B	MET274
B	HOH588

site_id	AC7
Number of Residues	15
Details	BINDING SITE FOR RESIDUE PLU A 500

Chain	Residue
A	LYS250
A	ASP255
A	LYS262
A	ASP273
A	ASP332
A	GLU334
A	THR359
A	LEU360
A	ALA451
A	MET454
A	ZN488
A	ZN489
A	HOH713
A	HOH756
A	HOH989

site_id	AC8
Number of Residues	14
Details	BINDING SITE FOR RESIDUE PLU B 500

Chain	Residue
B	LYS250
B	ASP255
B	LYS262
B	ASP273
B	ASP332
B	GLU334
B	THR359
B	LEU360
B	ALA451
B	ZN488
B	ZN489
B	HOH587
B	HOH929
B	HOH985

site_id	AC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MRD B 501

Chain	Residue
B	TRP82
B	ASN88
B	HOH545
B	HOH646
B	HOH707
B	HOH921

site_id	ASA
Number of Residues	11
Details

Chain	Residue
A	GLU334
A	THR361
A	GLY362
A	ASP255
A	ASP332
A	ASP273
A	LYS250
A	LYS262
A	GLY335
A	ARG336
A	LEU360

site_id	ASB
Number of Residues	11
Details

Chain	Residue
B	GLU334
B	ASP255
B	ASP332
B	ASP273
B	LYS250
B	LYS262
B	GLY335
B	ARG336
B	LEU360
B	THR361
B	GLY362

site_id	BC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MRD A 501

Chain	Residue
A	TRP82
A	ASN88
A	HOH576
A	HOH744
A	HOH831
B	HOH560

site_id	BC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MRD A 502

Chain	Residue
A	ARG52
A	HOH649
B	ASP102
A	LEU46
A	THR51

site_id	BC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MRD B 502

Chain	Residue
A	ASP102
A	LEU103
B	LEU46
B	LYS50
B	THR51
B	ARG52
B	HOH581

site_id	BC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE MRD A 503

Chain	Residue
A	HIS233
A	PRO244
A	ASN295
A	ILE296
A	VAL297
A	HOH568
A	HOH580
A	HOH841

site_id	BC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MRD B 503

Chain	Residue
B	ASN295
B	ILE296
B	HOH617
B	HOH889

Functional Information from PROSITE/UniProt

site_id	PS00631
Number of Residues	8
Details	CYTOSOL_AP Cytosol aminopeptidase signature. NTDAEGRL

Chain	Residue	Details
A	ASN330-LEU337

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"evidences":[{"source":"PubMed","id":"7578088","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"7619821","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"1LCP","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16519517","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17157838","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2EWB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2J9A","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"7619821","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1LCP","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"7578088","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7619821","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1LAN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1LCP","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16519517","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17157838","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8506345","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2EWB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2J9A","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16519517","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17157838","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8506345","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1BPM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2EWB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2J9A","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q68FS4","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	8
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"Q9CPY7","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q9CPY7","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P28838","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	4
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"Q9CPY7","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	Annotated By Reference To The Literature 1lam

Chain	Residue	Details
A	LYS262
A	ARG336
A	ASP255

site_id	CSA2
Number of Residues	3
Details	Annotated By Reference To The Literature 1lam

Chain	Residue	Details
B	LYS262
B	ARG336
B	ASP255

site_id	MCSA1
Number of Residues	2
Details	M-CSA 587

Chain	Residue	Details
A	LYS262	electrostatic stabiliser
A	ARG336	electrostatic stabiliser

site_id	MCSA2
Number of Residues	2
Details	M-CSA 587

Chain	Residue	Details
B	LYS262	electrostatic stabiliser
B	ARG336	electrostatic stabiliser

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)