1LAM

LEUCINE AMINOPEPTIDASE (UNLIGATED)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004177	molecular_function	aminopeptidase activity
A	0004180	molecular_function	carboxypeptidase activity
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0006508	biological_process	proteolysis
A	0008233	molecular_function	peptidase activity
A	0016787	molecular_function	hydrolase activity
A	0016805	molecular_function	dipeptidase activity
A	0019538	biological_process	protein metabolic process
A	0030145	molecular_function	manganese ion binding
A	0046872	molecular_function	metal ion binding
A	0070006	molecular_function	metalloaminopeptidase activity
A	0097718	molecular_function	disordered domain specific binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN A 488

Chain	Residue
A	ASP255
A	ASP332
A	GLU334
A	ZN489
A	HOH739

---

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE ZN A 489

Chain	Residue
A	LYS250
A	ASP255
A	ASP273
A	GLU334
A	ZN488
A	CO3500
A	HOH739

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ZN A 490

Chain	Residue
A	LEU170
A	MET171
A	THR173
A	ARG271
A	MET274
A	HOH570

---

site_id	AC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE CO3 A 500

Chain	Residue
A	LYS250
A	ALA333
A	GLU334
A	GLY335
A	ARG336
A	LEU360
A	ZN489
A	HOH739

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MRD A 501

Chain	Residue
A	TRP82
A	ASN88
A	HOH667
A	HOH679
A	HOH698
A	HOH821

---

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MRD A 502

Chain	Residue
A	LEU46
A	THR51
A	ARG52
A	ASP102
A	HOH595

---

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MRD A 503

Chain	Residue
A	HIS233
A	ASN295
A	ILE296
A	VAL297

---

site_id	AS
Number of Residues	11
Details	RESIDUES AROUND THE AMINOPEPTIDASE ACTIVE SITE

Chain	Residue
A	GLU334
A	THR361
A	GLY362
A	ASP255
A	ASP332
A	ASP273
A	LYS250
A	LYS262
A	GLY335
A	ARG336
A	LEU360

---

Functional Information from PROSITE/UniProt

site_id	PS00631
Number of Residues	8
Details	CYTOSOL_AP Cytosol aminopeptidase signature. NTDAEGRL

Chain	Residue	Details
A	ASN330-LEU337

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"evidences":[{"source":"PubMed","id":"7578088","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"7619821","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"1LCP","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16519517","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17157838","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2EWB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2J9A","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"7619821","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1LCP","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"7578088","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7619821","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1LAN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1LCP","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16519517","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17157838","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8506345","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2EWB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2J9A","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16519517","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17157838","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8506345","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1BPM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2EWB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2J9A","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q68FS4","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	4
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"Q9CPY7","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q9CPY7","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P28838","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	2
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"Q9CPY7","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	a catalytic site defined by CSA, PubMed 10500145, 7578088

Chain	Residue	Details
A	LYS262
A	ARG336

---

site_id	MCSA1
Number of Residues	2
Details	M-CSA 587

Chain	Residue	Details
A	LYS262	electrostatic stabiliser
A	ARG336	electrostatic stabiliser

---