Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1L7V

Bacterial ABC Transporter Involved in B12 Uptake

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005886	cellular_component	plasma membrane
A	0015420	molecular_function	ABC-type vitamin B12 transporter activity
A	0015889	biological_process	cobalamin transport
A	0016020	cellular_component	membrane
A	0022857	molecular_function	transmembrane transporter activity
A	0035461	biological_process	vitamin transmembrane transport
A	0042802	molecular_function	identical protein binding
A	0043190	cellular_component	ATP-binding cassette (ABC) transporter complex
A	0055085	biological_process	transmembrane transport
A	0090482	molecular_function	vitamin transmembrane transporter activity
A	1990191	cellular_component	cobalamin transport complex
A	1990193	cellular_component	BtuCD complex
B	0005515	molecular_function	protein binding
B	0005886	cellular_component	plasma membrane
B	0015420	molecular_function	ABC-type vitamin B12 transporter activity
B	0015889	biological_process	cobalamin transport
B	0016020	cellular_component	membrane
B	0022857	molecular_function	transmembrane transporter activity
B	0035461	biological_process	vitamin transmembrane transport
B	0042802	molecular_function	identical protein binding
B	0043190	cellular_component	ATP-binding cassette (ABC) transporter complex
B	0055085	biological_process	transmembrane transport
B	0090482	molecular_function	vitamin transmembrane transporter activity
B	1990191	cellular_component	cobalamin transport complex
B	1990193	cellular_component	BtuCD complex
C	0000166	molecular_function	nucleotide binding
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005886	cellular_component	plasma membrane
C	0015420	molecular_function	ABC-type vitamin B12 transporter activity
C	0015889	biological_process	cobalamin transport
C	0016020	cellular_component	membrane
C	0016887	molecular_function	ATP hydrolysis activity
C	0019898	cellular_component	extrinsic component of membrane
C	0042626	molecular_function	ATPase-coupled transmembrane transporter activity
C	0043190	cellular_component	ATP-binding cassette (ABC) transporter complex
C	0055085	biological_process	transmembrane transport
C	1990191	cellular_component	cobalamin transport complex
C	1990193	cellular_component	BtuCD complex
D	0000166	molecular_function	nucleotide binding
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005886	cellular_component	plasma membrane
D	0015420	molecular_function	ABC-type vitamin B12 transporter activity
D	0015889	biological_process	cobalamin transport
D	0016020	cellular_component	membrane
D	0016887	molecular_function	ATP hydrolysis activity
D	0019898	cellular_component	extrinsic component of membrane
D	0042626	molecular_function	ATPase-coupled transmembrane transporter activity
D	0043190	cellular_component	ATP-binding cassette (ABC) transporter complex
D	0055085	biological_process	transmembrane transport
D	1990191	cellular_component	cobalamin transport complex
D	1990193	cellular_component	BtuCD complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE V4O C 250

Chain	Residue
C	PRO34
C	ASN35
C	GLY36
C	ALA37
C	GLY38
C	LYS39
C	SER40
C	THR41

site_id	AC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE V4O D 250

Chain	Residue
D	ASN35
D	GLY36
D	ALA37
D	GLY38
D	LYS39
D	SER40
D	THR41
D	PRO34

Functional Information from PROSITE/UniProt

site_id	PS00211
Number of Residues	15
Details	ABC_TRANSPORTER_1 ABC transporters family signature. LSGGEWQRVRLAAVV

Chain	Residue	Details
C	LEU127-VAL141

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	BINDING: BINDING => ECO:0000255\|HAMAP-Rule:MF_01005

Chain	Residue	Details
C	GLY33
B	GLN207-LEU228
B	GLY268-VAL274
B	GLY325-ARG326
D	GLY33
A	HIS139-SER141
A	GLN207-LEU228
A	GLY268-VAL274
A	GLY325-ARG326
B	MSE1-ARG10
B	GLU82-GLY92
B	HIS139-SER141

site_id	SWS_FT_FI2
Number of Residues	48
Details	TRANSMEM: Helical; Name=1

Chain	Residue	Details
A	GLN11-GLU35
B	GLN11-GLU35

site_id	SWS_FT_FI3
Number of Residues	124
Details	TOPO_DOM: Periplasmic => ECO:0000269\|PubMed:15919996

Chain	Residue	Details
A	GLN36-ARG56
B	ALA297-PRO304
A	GLY108-PRO113
A	SER167-GLN190
A	ALA250-GLY257
A	ALA297-PRO304
B	GLN36-ARG56
B	GLY108-PRO113
B	SER167-GLN190
B	ALA250-GLY257

site_id	SWS_FT_FI4
Number of Residues	48
Details	TRANSMEM: Helical; Name=2

Chain	Residue	Details
A	LEU57-PHE81
B	LEU57-PHE81

site_id	SWS_FT_FI5
Number of Residues	28
Details	TRANSMEM: Helical; Name=3

Chain	Residue	Details
A	VAL93-LEU107
B	VAL93-LEU107

site_id	SWS_FT_FI6
Number of Residues	48
Details	TRANSMEM: Helical; Name=4

Chain	Residue	Details
A	ASN114-ARG138
B	ASN114-ARG138

site_id	SWS_FT_FI7
Number of Residues	48
Details	TRANSMEM: Helical; Name=5

Chain	Residue	Details
A	THR142-PHE166
B	THR142-PHE166

site_id	SWS_FT_FI8
Number of Residues	30
Details	TRANSMEM: Helical; Name=6

Chain	Residue	Details
A	SER191-CYS206
B	SER191-CYS206

site_id	SWS_FT_FI9
Number of Residues	40
Details	TRANSMEM: Helical; Name=7

Chain	Residue	Details
A	TRP229-LEU249
B	TRP229-LEU249

site_id	SWS_FT_FI10
Number of Residues	18
Details	TRANSMEM: Helical; Name=8

Chain	Residue	Details
A	LEU258-CYS267
B	LEU258-CYS267

site_id	SWS_FT_FI11
Number of Residues	42
Details	TRANSMEM: Helical; Name=9

Chain	Residue	Details
A	LEU275-LEU296
B	LEU275-LEU296

site_id	SWS_FT_FI12
Number of Residues	38
Details	TRANSMEM: Helical; Name=10

Chain	Residue	Details
A	ILE305-ALA324
B	ILE305-ALA324

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)