1L7D
Crystal Structure of R. rubrum Transhydrogenase Domain I without Bound NAD(H)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0003957 | molecular_function | NAD(P)+ transhydrogenase (Si-specific) activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0006740 | biological_process | NADPH regeneration |
| A | 0008750 | molecular_function | proton-translocating NAD(P)+ transhydrogenase activity |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0046983 | molecular_function | protein dimerization activity |
| A | 0051287 | molecular_function | NAD binding |
| A | 0070403 | molecular_function | NAD+ binding |
| A | 0070404 | molecular_function | NADH binding |
| A | 1902600 | biological_process | proton transmembrane transport |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0003957 | molecular_function | NAD(P)+ transhydrogenase (Si-specific) activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0006740 | biological_process | NADPH regeneration |
| B | 0008750 | molecular_function | proton-translocating NAD(P)+ transhydrogenase activity |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0046983 | molecular_function | protein dimerization activity |
| B | 0051287 | molecular_function | NAD binding |
| B | 0070403 | molecular_function | NAD+ binding |
| B | 0070404 | molecular_function | NADH binding |
| B | 1902600 | biological_process | proton transmembrane transport |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0003957 | molecular_function | NAD(P)+ transhydrogenase (Si-specific) activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0006740 | biological_process | NADPH regeneration |
| C | 0008750 | molecular_function | proton-translocating NAD(P)+ transhydrogenase activity |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0046983 | molecular_function | protein dimerization activity |
| C | 0051287 | molecular_function | NAD binding |
| C | 0070403 | molecular_function | NAD+ binding |
| C | 0070404 | molecular_function | NADH binding |
| C | 1902600 | biological_process | proton transmembrane transport |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0003957 | molecular_function | NAD(P)+ transhydrogenase (Si-specific) activity |
| D | 0005515 | molecular_function | protein binding |
| D | 0006740 | biological_process | NADPH regeneration |
| D | 0008750 | molecular_function | proton-translocating NAD(P)+ transhydrogenase activity |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0046983 | molecular_function | protein dimerization activity |
| D | 0051287 | molecular_function | NAD binding |
| D | 0070403 | molecular_function | NAD+ binding |
| D | 0070404 | molecular_function | NADH binding |
| D | 1902600 | biological_process | proton transmembrane transport |
Functional Information from PROSITE/UniProt
| site_id | PS00836 |
| Number of Residues | 27 |
| Details | ALADH_PNT_1 Alanine dehydrogenase & pyridine nucleotide transhydrogenase signature 1. AIPkErrpGEd..RVAiSPeVVkkLvGlG |
| Chain | Residue | Details |
| A | ALA4-GLY30 |
| site_id | PS00837 |
| Number of Residues | 26 |
| Details | ALADH_PNT_2 Alanine dehydrogenase & pyridine nucleotide transhydrogenase signature 2. VFGVGvAGlqAiatAkRLGAvVmatD |
| Chain | Residue | Details |
| A | VAL177-ASP202 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 28 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:10997900, ECO:0000269|PubMed:11250201, ECO:0000269|PubMed:15670609 |
| Chain | Residue | Details |
| A | GLN132 | |
| D | GLN1332 | |
| D | ASP1402 | |
| D | GLY1434 | |
| A | ARG127 | |
| A | VAL180 | |
| A | GLN247 | |
| A | LEU266 | |
| B | ARG527 | |
| B | VAL580 | |
| B | GLN647 | |
| A | ASP202 | |
| B | LEU666 | |
| C | ARG927 | |
| C | VAL980 | |
| C | GLN1047 | |
| C | LEU1066 | |
| D | ARG1327 | |
| D | VAL1380 | |
| D | GLN1447 | |
| D | LEU1466 | |
| A | GLY234 | |
| B | GLN532 | |
| B | ASP602 | |
| B | GLY634 | |
| C | GLN932 | |
| C | ASP1002 | |
| C | GLY1034 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000250 |
| Chain | Residue | Details |
| A | VAL182 | |
| B | VAL582 | |
| C | VAL982 | |
| D | VAL1382 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 4 |
| Details |
| Chain | Residue | Details |
| A | ASP135 | |
| A | SER138 | |
| A | ARG127 | |
| A | GLN132 |
| site_id | CSA2 |
| Number of Residues | 4 |
| Details |
| Chain | Residue | Details |
| B | ARG527 | |
| B | GLN532 | |
| B | SER538 | |
| B | ASP535 |
| site_id | CSA3 |
| Number of Residues | 4 |
| Details |
| Chain | Residue | Details |
| C | SER938 | |
| C | GLN932 | |
| C | ASP935 | |
| C | ARG927 |
| site_id | CSA4 |
| Number of Residues | 4 |
| Details |
| Chain | Residue | Details |
| D | ASP1335 | |
| D | ARG1327 | |
| D | GLN1332 | |
| D | SER1338 |
| site_id | MCSA1 |
| Number of Residues | 5 |
| Details | M-CSA 116 |
| Chain | Residue | Details |
| A | ARG127 | hydrogen bond donor, steric role |
| A | GLN132 | steric locator |
| A | ASP135 | hydrogen bond acceptor, steric role |
| A | SER138 | electrostatic stabiliser |
| A | TYR235 | polar/non-polar interaction, steric role |
| site_id | MCSA2 |
| Number of Residues | 5 |
| Details | M-CSA 116 |
| Chain | Residue | Details |
| B | ARG527 | hydrogen bond donor, steric role |
| B | GLN532 | steric locator |
| B | ASP535 | hydrogen bond acceptor, steric role |
| B | SER538 | electrostatic stabiliser |
| B | TYR635 | polar/non-polar interaction, steric role |
| site_id | MCSA3 |
| Number of Residues | 5 |
| Details | M-CSA 116 |
| Chain | Residue | Details |
| C | ARG927 | hydrogen bond donor, steric role |
| C | GLN932 | steric locator |
| C | ASP935 | hydrogen bond acceptor, steric role |
| C | SER938 | electrostatic stabiliser |
| C | TYR1035 | polar/non-polar interaction, steric role |
| site_id | MCSA4 |
| Number of Residues | 5 |
| Details | M-CSA 116 |
| Chain | Residue | Details |
| D | ARG1327 | hydrogen bond donor, steric role |
| D | GLN1332 | steric locator |
| D | ASP1335 | hydrogen bond acceptor, steric role |
| D | SER1338 | electrostatic stabiliser |
| D | TYR1435 | polar/non-polar interaction, steric role |
