Loading
PDBj
MenuPDBj@FacebookPDBj@X(formerly Twitter)PDBj@BlueSkyPDBj@YouTubewwPDB FoundationwwPDBDonate
RCSB PDBPDBeBMRBAdv. SearchSearch help

1L6M

Neutrophil Gelatinase-associated Lipocalin is a Novel Bacteriostatic Agent that Interferes with Siderophore-mediated Iron Acquisition

Functional Information from GO Data
ChainGOidnamespacecontents
A0002020molecular_functionprotease binding
A0002376biological_processimmune system process
A0005506molecular_functioniron ion binding
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0006811biological_processmonoatomic ion transport
A0006826biological_processiron ion transport
A0006915biological_processapoptotic process
A0006953biological_processacute-phase response
A0006979biological_processresponse to oxidative stress
A0007614biological_processshort-term memory
A0007616biological_processlong-term memory
A0009410biological_processresponse to xenobiotic stimulus
A0009615biological_processresponse to virus
A0009617biological_processresponse to bacterium
A0009635biological_processresponse to herbicide
A0009636biological_processresponse to toxic substance
A0009637biological_processresponse to blue light
A0009750biological_processresponse to fructose
A0010040biological_processresponse to iron(II) ion
A0010046biological_processresponse to mycotoxin
A0010595biological_processpositive regulation of endothelial cell migration
A0010628biological_processpositive regulation of gene expression
A0015891biological_processsiderophore transport
A0031346biological_processpositive regulation of cell projection organization
A0031410cellular_componentcytoplasmic vesicle
A0031667biological_processresponse to nutrient levels
A0031669biological_processcellular response to nutrient levels
A0032496biological_processresponse to lipopolysaccharide
A0035580cellular_componentspecific granule lumen
A0036094molecular_functionsmall molecule binding
A0036295biological_processcellular response to increased oxygen levels
A0042742biological_processdefense response to bacterium
A0042802molecular_functionidentical protein binding
A0043065biological_processpositive regulation of apoptotic process
A0043525biological_processpositive regulation of neuron apoptotic process
A0045087biological_processinnate immune response
A0060205cellular_componentcytoplasmic vesicle lumen
A0070062cellular_componentextracellular exosome
A0070301biological_processcellular response to hydrogen peroxide
A0071222biological_processcellular response to lipopolysaccharide
A0071347biological_processcellular response to interleukin-1
A0071354biological_processcellular response to interleukin-6
A0071356biological_processcellular response to tumor necrosis factor
A0071456biological_processcellular response to hypoxia
A0071481biological_processcellular response to X-ray
A0097192biological_processextrinsic apoptotic signaling pathway in absence of ligand
A0110090biological_processpositive regulation of hippocampal neuron apoptotic process
A0110091biological_processnegative regulation of hippocampal neuron apoptotic process
A0120162biological_processpositive regulation of cold-induced thermogenesis
A0140315molecular_functioniron ion sequestering activity
A1903428biological_processpositive regulation of reactive oxygen species biosynthetic process
A1903981molecular_functionenterobactin binding
A1904373biological_processresponse to kainic acid
A1904440biological_processpositive regulation of iron ion import across plasma membrane
A1904646biological_processcellular response to amyloid-beta
A1905956biological_processpositive regulation of endothelial tube morphogenesis
A1990090biological_processcellular response to nerve growth factor stimulus
A2000379biological_processpositive regulation of reactive oxygen species metabolic process
B0002020molecular_functionprotease binding
B0002376biological_processimmune system process
B0005506molecular_functioniron ion binding
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0006811biological_processmonoatomic ion transport
B0006826biological_processiron ion transport
B0006915biological_processapoptotic process
B0006953biological_processacute-phase response
B0006979biological_processresponse to oxidative stress
B0007614biological_processshort-term memory
B0007616biological_processlong-term memory
B0009410biological_processresponse to xenobiotic stimulus
B0009615biological_processresponse to virus
B0009617biological_processresponse to bacterium
B0009635biological_processresponse to herbicide
B0009636biological_processresponse to toxic substance
B0009637biological_processresponse to blue light
B0009750biological_processresponse to fructose
B0010040biological_processresponse to iron(II) ion
B0010046biological_processresponse to mycotoxin
B0010595biological_processpositive regulation of endothelial cell migration
B0010628biological_processpositive regulation of gene expression
B0015891biological_processsiderophore transport
B0031346biological_processpositive regulation of cell projection organization
B0031410cellular_componentcytoplasmic vesicle
B0031667biological_processresponse to nutrient levels
B0031669biological_processcellular response to nutrient levels
B0032496biological_processresponse to lipopolysaccharide
B0035580cellular_componentspecific granule lumen
B0036094molecular_functionsmall molecule binding
B0036295biological_processcellular response to increased oxygen levels
B0042742biological_processdefense response to bacterium
B0042802molecular_functionidentical protein binding
B0043065biological_processpositive regulation of apoptotic process
B0043525biological_processpositive regulation of neuron apoptotic process
B0045087biological_processinnate immune response
B0060205cellular_componentcytoplasmic vesicle lumen
B0070062cellular_componentextracellular exosome
B0070301biological_processcellular response to hydrogen peroxide
B0071222biological_processcellular response to lipopolysaccharide
B0071347biological_processcellular response to interleukin-1
B0071354biological_processcellular response to interleukin-6
B0071356biological_processcellular response to tumor necrosis factor
B0071456biological_processcellular response to hypoxia
B0071481biological_processcellular response to X-ray
B0097192biological_processextrinsic apoptotic signaling pathway in absence of ligand
B0110090biological_processpositive regulation of hippocampal neuron apoptotic process
B0110091biological_processnegative regulation of hippocampal neuron apoptotic process
B0120162biological_processpositive regulation of cold-induced thermogenesis
B0140315molecular_functioniron ion sequestering activity
B1903428biological_processpositive regulation of reactive oxygen species biosynthetic process
B1903981molecular_functionenterobactin binding
B1904373biological_processresponse to kainic acid
B1904440biological_processpositive regulation of iron ion import across plasma membrane
B1904646biological_processcellular response to amyloid-beta
B1905956biological_processpositive regulation of endothelial tube morphogenesis
B1990090biological_processcellular response to nerve growth factor stimulus
B2000379biological_processpositive regulation of reactive oxygen species metabolic process
C0002020molecular_functionprotease binding
C0002376biological_processimmune system process
C0005506molecular_functioniron ion binding
C0005515molecular_functionprotein binding
C0005576cellular_componentextracellular region
C0005615cellular_componentextracellular space
C0006811biological_processmonoatomic ion transport
C0006826biological_processiron ion transport
C0006915biological_processapoptotic process
C0006953biological_processacute-phase response
C0006979biological_processresponse to oxidative stress
C0007614biological_processshort-term memory
C0007616biological_processlong-term memory
C0009410biological_processresponse to xenobiotic stimulus
C0009615biological_processresponse to virus
C0009617biological_processresponse to bacterium
C0009635biological_processresponse to herbicide
C0009636biological_processresponse to toxic substance
C0009637biological_processresponse to blue light
C0009750biological_processresponse to fructose
C0010040biological_processresponse to iron(II) ion
C0010046biological_processresponse to mycotoxin
C0010595biological_processpositive regulation of endothelial cell migration
C0010628biological_processpositive regulation of gene expression
C0015891biological_processsiderophore transport
C0031346biological_processpositive regulation of cell projection organization
C0031410cellular_componentcytoplasmic vesicle
C0031667biological_processresponse to nutrient levels
C0031669biological_processcellular response to nutrient levels
C0032496biological_processresponse to lipopolysaccharide
C0035580cellular_componentspecific granule lumen
C0036094molecular_functionsmall molecule binding
C0036295biological_processcellular response to increased oxygen levels
C0042742biological_processdefense response to bacterium
C0042802molecular_functionidentical protein binding
C0043065biological_processpositive regulation of apoptotic process
C0043525biological_processpositive regulation of neuron apoptotic process
C0045087biological_processinnate immune response
C0060205cellular_componentcytoplasmic vesicle lumen
C0070062cellular_componentextracellular exosome
C0070301biological_processcellular response to hydrogen peroxide
C0071222biological_processcellular response to lipopolysaccharide
C0071347biological_processcellular response to interleukin-1
C0071354biological_processcellular response to interleukin-6
C0071356biological_processcellular response to tumor necrosis factor
C0071456biological_processcellular response to hypoxia
C0071481biological_processcellular response to X-ray
C0097192biological_processextrinsic apoptotic signaling pathway in absence of ligand
C0110090biological_processpositive regulation of hippocampal neuron apoptotic process
C0110091biological_processnegative regulation of hippocampal neuron apoptotic process
C0120162biological_processpositive regulation of cold-induced thermogenesis
C0140315molecular_functioniron ion sequestering activity
C1903428biological_processpositive regulation of reactive oxygen species biosynthetic process
C1903981molecular_functionenterobactin binding
C1904373biological_processresponse to kainic acid
C1904440biological_processpositive regulation of iron ion import across plasma membrane
C1904646biological_processcellular response to amyloid-beta
C1905956biological_processpositive regulation of endothelial tube morphogenesis
C1990090biological_processcellular response to nerve growth factor stimulus
C2000379biological_processpositive regulation of reactive oxygen species metabolic process
Functional Information from PDB Data
site_idAC1
Number of Residues3
DetailsBINDING SITE FOR RESIDUE FE A 200
ChainResidue
ADBH201
ADBH202
ADBS203

site_idAC2
Number of Residues3
DetailsBINDING SITE FOR RESIDUE FE B 300
ChainResidue
BDBH301
BDBH302
BDBS303

site_idAC3
Number of Residues2
DetailsBINDING SITE FOR RESIDUE FE C 400
ChainResidue
CDBH401
CDBS403

site_idAC4
Number of Residues4
DetailsBINDING SITE FOR RESIDUE SO4 A 230
ChainResidue
AASP61
ASER63
ATHR82
ALYS59

site_idAC5
Number of Residues4
DetailsBINDING SITE FOR RESIDUE SO4 C 330
ChainResidue
CLYS59
CASP61
CSER63
CTHR82

site_idAC6
Number of Residues3
DetailsBINDING SITE FOR RESIDUE SO4 C 430
ChainResidue
ALYS75
CASN164
CHIS165

site_idAC7
Number of Residues8
DetailsBINDING SITE FOR RESIDUE DBH A 201
ChainResidue
ATYR52
ASER68
ATRP79
AARG81
ALYS134
AFE200
ADBH202
ADBS203

site_idAC8
Number of Residues9
DetailsBINDING SITE FOR RESIDUE DBH A 202
ChainResidue
ATRP79
AARG81
ALEU94
ATYR100
ATYR106
ALYS125
AFE200
ADBH201
ADBS203

site_idAC9
Number of Residues10
DetailsBINDING SITE FOR RESIDUE DBS A 203
ChainResidue
AALA40
ATYR106
APHE123
ALYS125
ATYR132
ALYS134
AFE200
ADBH201
ADBH202
AHOH501

site_idBC1
Number of Residues7
DetailsBINDING SITE FOR RESIDUE DBH B 301
ChainResidue
BSER68
BARG81
BLYS134
BFE300
BDBH302
BDBS303
BHOH509

site_idBC2
Number of Residues5
DetailsBINDING SITE FOR RESIDUE DBH B 302
ChainResidue
BTYR106
BLYS125
BFE300
BDBH301
BDBS303

site_idBC3
Number of Residues8
DetailsBINDING SITE FOR RESIDUE DBS B 303
ChainResidue
BALA40
BTYR106
BPHE123
BLYS125
BLYS134
BFE300
BDBH301
BDBH302

site_idBC4
Number of Residues8
DetailsBINDING SITE FOR RESIDUE DBH C 401
ChainResidue
CTYR52
CSER68
CTRP79
CARG81
CPHE123
CLYS134
CFE400
CDBS403

site_idBC5
Number of Residues7
DetailsBINDING SITE FOR RESIDUE DBS C 403
ChainResidue
CALA40
CTYR106
CPHE123
CLYS125
CLYS134
CFE400
CDBH401

Functional Information from PROSITE/UniProt
site_idPS00213
Number of Residues14
DetailsLIPOCALIN Lipocalin signature. NFQdnQFQGKWYVV
ChainResidueDetails
AASN21-VAL34

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3
DetailsBINDING: BINDING => ECO:0007744|PDB:1X89, ECO:0007744|PDB:1X8U
ChainResidueDetails
ATYR52
BTYR52
CTYR52

site_idSWS_FT_FI2
Number of Residues6
DetailsBINDING: BINDING => ECO:0007744|PDB:3CMP
ChainResidueDetails
ATYR106
ALYS134
BTYR106
BLYS134
CTYR106
CLYS134

site_idSWS_FT_FI3
Number of Residues6
DetailsBINDING: BINDING => ECO:0000269|PubMed:15642259, ECO:0007744|PDB:1X89, ECO:0007744|PDB:1X8U
ChainResidueDetails
ALYS125
ATYR138
BLYS125
BTYR138
CLYS125
CTYR138

site_idSWS_FT_FI4
Number of Residues3
DetailsMOD_RES: Pyrrolidone carboxylic acid => ECO:0000269|PubMed:7683678
ChainResidueDetails
AGLN1
BGLN1
CGLN1

site_idSWS_FT_FI5
Number of Residues3
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:10684642, ECO:0000269|PubMed:15084671, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:16740002, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:7683678, ECO:0007744|PDB:1DFV, ECO:0007744|PDB:1QQS
ChainResidueDetails
AASN65
BASN65
CASN65

234136

PDB entries from 2025-04-02

PDB statisticsPDBj update infoContact PDBjnumon