Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004252 | molecular_function | serine-type endopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| B | 0005576 | cellular_component | extracellular region |
| B | 0031639 | biological_process | plasminogen activation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 215 |
| Chain | Residue |
| A | ARG644 |
| A | GLN721 |
| A | SER722 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 A 216 |
| Chain | Residue |
| B | ARG45 |
| B | HOH162 |
| A | HOH170 |
| A | PRO768 |
| A | ASN769 |
| A | LYS770 |
| B | THR29 |
| B | ASN30 |
Functional Information from PROSITE/UniProt
| site_id | PS00134 |
| Number of Residues | 6 |
| Details | TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC |
| Chain | Residue | Details |
| A | LEU599-CYS604 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | ACT_SITE: Charge relay system |
| Chain | Residue | Details |
| A | HIS603 | |
| A | ASP646 | |
| A | ALA741 | |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | SITE: Cleavage; by plasminogen activator |
| Chain | Residue | Details |
| A | ARG561 | |
| Chain | Residue | Details |
| A | SER578 | |
| Chain | Residue | Details |
| A | SER669 | |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1qrz |
| Chain | Residue | Details |
| A | HIS603 | |
| A | ASP646 | |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1qrz |
| Chain | Residue | Details |
| A | ALA741 | |
| A | GLY742 | |
| site_id | CSA3 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1qrz |
| Chain | Residue | Details |
| A | ALA741 | |
| A | GLY739 | |
| site_id | CSA4 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1qrz |
| Chain | Residue | Details |
| A | HIS603 | |
| A | ALA741 | |
| A | ASP646 | |
| A | GLY742 | |
| site_id | CSA5 |
| Number of Residues | 7 |
| Details | Annotated By Reference To The Literature 1qrz |
| Chain | Residue | Details |
| A | CYS737 | |
| A | HIS603 | |
| A | ALA741 | |
| A | ASP740 | |
| A | ASP646 | |
| A | GLY739 | |
| A | GLN738 | |
| site_id | MCSA1 |
| Number of Residues | 4 |
| Details | M-CSA 425 |
| Chain | Residue | Details |
| A | HIS603 | proton shuttle (general acid/base) |
| A | ASP646 | electrostatic stabiliser, modifies pKa |
| A | ALA741 | covalent catalysis, proton shuttle (general acid/base) |
| A | GLY742 | electrostatic stabiliser |
